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Bult, W. (author), De Leeuw, H. (author), Steinebach, O.M. (author), Van der Bom, M.J. (author), Wolterbeek, H.T. (author), Heeren, R.M.A. (author), Bakker, C.J.G. (author), Van het Schip, A.D. (author), Hennink, W.E. (author), Nijsen, F.W. (author)Purpose The clinical application of holmium acetylacetonate microspheres (HoAcAcMS) for the intratumoral radionuclide treatment of solid malignancies requires a thorough understanding of their stability. Therefore, an in vitro and an in vivo stability study with HoAcAcMS was conducted. Methods HoAcAcMS, before and after neutron irradiation, were...journal article 2011
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Zielhuis, S.W. (author), Seppenwoolde, J.H. (author), Mateus, V.A.P. (author), Bakker, C.J.G. (author), Krijger, G.C. (author), Storm, G. (author), Zonnenberg, B.A. (author), Van het Schip, A.D. (author), Koning, G.A. (author), Nijsen, J.F.W. (author)Many advanced molecular imaging agents are currently being investigated preclinically. Especially, liposomes, have proven to be very promising carrier systems for diagnostic agents for use in single-photon emission computed tomography (SPECT) or magnetic resonance imaging (MRI), as well as for therapeutic agents to treat diseases such as cancer....journal article 2006