- document
-
Motreuil-Ragot, P.A. (author)An organ-on-chip (OoC) is a microelectromechanical (MEMS) device that aims to recapitulate in-vitro the physiology of the smallest functional unit of an organ in order to perform drug analysis or study disease models. OoCs are very complex systems that require actuation and sensing capabilities within controlled and delicate environment. The...doctoral thesis 2023
- document
-
Dutta, S. (author), Bieling, T.J. (author), Verbiest, G.J. (author)Fluid flow processes such as drainage and evaporation in porous media are crucial in geological and biological systems. The motion of the displacement front of a moving fluid through multi-phase interfaces is often associated with abrupt mechanical energy release, detectable as acoustic emissions (AEs). The exact origin of these pulses and...journal article 2023
- document
-
Muralidharan, A. (author)Delivery of biomolecules using pulsed electric fields or electrotransfer has applications such as biomedical engineering, bioprocess engineering and genomic engineering. When a cell is placed in an electric field, the induced transmembrane voltage catalyzes the formation of pores on the cell membrane. This enables the delivery of otherwise cell...doctoral thesis 2022
- document
-
Campos de Oliveira, A. (author), Pan, Sining (author), Wiegerink, Remco J. (author), Makinwa, K.A.A. (author)This article presents a microelectromechanical system (MEMS) Coriolis-based mass-flow-to-digital converter (Φ DC) that can be used with both liquids and gases. It consists of a micromachined Coriolis mass flow sensor and a CMOS interface circuit that drives it into oscillation and digitizes the resulting mass flow information. A phase-locked...journal article 2022
- document
-
Büke, F. (author), Grilli, Jacopo (author), Cosentino Lagomarsino, Marco (author), Bokinsky, G.E. (author), Tans, S.J. (author)Growth and division are central to cell size. Bacteria achieve size homeostasis by dividing when growth has added a constant size since birth, termed the adder principle, by unknown mechanisms.<sup>1</sup><sup>,</sup><sup>2</sup> Growth is well known to be regulated by guanosine tetraphosphate (ppGpp), which controls diverse processes from...journal article 2022
- document
-
Mehta, P.P. (author), Rahman, Z. (author), ten Dijke, Peter (author), Boukany, P. (author)An early step of metastasis requires a complex and coordinated migration of invasive tumor cells into the surrounding tumor microenvironment (TME), which contains extracellular matrix (ECM). It is being appreciated that 3D matrix-based microfluidic models have an advantage over conventional in vitro and animal models to study tumor...review 2022
- document
-
Motreuil-Ragot, P.A. (author), Turcan, G. (author), de Wagenaar, B. (author), Hunt, A. (author), Sarro, Pasqualina M (author), Mastrangeli, Massimo (author)Sensing flow rates in structured microenvironments like lab-on-chip (LOC) and organ-on-chip (OoC) is crucial to assess important parameters such as transport of media and molecules of interest. So far, these micro-electromechanical systems for biology (bio-MEMS) mostly rely on flow sensing systems based on thermal sensors. However, thermal...conference paper 2022
- document
-
van Putten, R. (author), Eyke, Natalie S. (author), Baumgartner, L.M. (author), Schultz, Victor L. (author), Filonenko, G.A. (author), Jensen, Klavs F. (author), Pidko, E.A. (author)Automation and microfluidic tools potentially enable efficient, fast, and focused reaction development of complex chemistries, while minimizing resource- and material consumption. The introduction of automation-assisted workflows will contribute to the more sustainable development and scale-up of new and improved catalytic technologies....journal article 2022
- document
-
Neves Sao Pedro, M. (author), Silva dos Santos, M. (author), Eppink, Michel H.M. (author), Ottens, M. (author)A major challenge in the transition to continuous biomanufacturing is the lack of process analytical technology (PAT) tools which are able to collect real-time information on the process and elicit a response to facilitate control. One of the critical quality attributes (CQAs) of interest during monoclonal antibodies production is aggregate...journal article 2022
- document
-
Amador, G.J. (author), van Dijk, Dennis (author), Kieffer, R.Y. (author), Aubin-Tam, M.E. (author), Tam, D.S.W. (author)Vital biological processes, such as trafficking, sensing, and motility, are facilitated by cellular lipid membranes, which interact mechanically with surrounding fluids. Such lipid membranes are only a few nanometers thick and composed of a liquid crystalline structure known as the lipid bilayer. Here, we introduce an active, noncontact, two...journal article 2021
- document
-
Picanço Castanheira Da Silva, T. (author), Eppink, Michel (author), Ottens, M. (author)Process development in the biotech industry leads to investments around hundred of millions of dollars. It is important to mitigate costs without neglecting the quality of process development. Biopharmaceutical process development is important for companies to develop new processes and be first to market, improve a pre-established process, or...review 2021
- document
-
Neves Sao Pedro, M. (author), Picanço Castanheira Da Silva, T. (author), Patil, Rohan (author), Ottens, M. (author)Continuous manufacturing is an indicator of a maturing industry, as can be seen by the example of the petrochemical industry. Patent expiry promotes a price competition between manufacturing companies, and more efficient and cheaper processes are needed to achieve lower production costs. Over the last decade, continuous biomanufacturing has...journal article 2021
- document
-
Van Delft, Falco C.M.J.M. (author), Sudalaiyadum Perumal, Ayyappasamy (author), van Langen-Suurling, A.K. (author), de Boer, C.R. (author), Kašpar, Ondřej (author), Tokárová, Viola (author), Dirne, F. (author), Nicolau, Dan V. (author)Non-deterministic polynomial (NP-) complete problems, whose number of possible solutions grows exponentially with the number of variables, require by necessity massively parallel computation. Because sequential computers, such as solid state-based ones, can solve only small instances of these problems within a reasonable time frame, parallel...journal article 2021
- document
-
Aydin, E. (author), Makinwa, K.A.A. (author)This paper presents a portable and contactless microfluidic flowmeter based on the Nuclear Magnetic Resonance (NMR) principle, which can measure flow rates up to 2.7 ml/min with \pm 16\ lmin (±0.6% full-scale) error. It consists of a millimeter-size RF coil wound around a microfluidic channel, custom readout electronics and a 0.5 T permanent...conference paper 2021
- document
-
Büke, F. (author)Bacteria have been an integral part of human life since the ancient times either as cooperative tenants living in and around us or as constant threats to our health and wellbeing. Since prehistoric times we unknowingly used them as tools of fermentation and fought against them with haphazardly discovered natural remedies. Today, after more than...doctoral thesis 2020
- document
-
Fanalista, F. (author)Cell replication is a fascinating biological process that ensures the proliferation of a species via division of a mother cell into two daughter ones. This process in bacteria is performed by a complex protein machinery named the Z-ring, which assembles at the cell mid-plane and promotes progressive membrane constriction down to division. A...doctoral thesis 2020
- document
- Sachdev, S. (author) doctoral thesis 2020
- document
-
Last, M.G.F. (author), Deshpande, S.R. (author), Dekker, C. (author)Membraneless organelles formed by liquid-liquid phase separation are dynamic structures that are employed by cells to spatiotemporally regulate their interior. Indeed, complex coacervation-based phase separation is involved in a multitude of biological tasks ranging from photosynthesis to cell division to chromatin organization, and more....journal article 2020
- document
-
Georgiev, R.N. (author), Toscano, Sara O. (author), Uspal, William E. (author), Bet, Bram (author), Samin, Sela (author), van Roij, René (author), Eral, H.B. (author)Comprehensive understanding of particle motion in microfluidic devices is essential to unlock additional technologies for shape-based separation and sorting of microparticles like microplastics, cells, and crystal polymorphs. Such particles interact hydrodynamically with confining surfaces, thus altering their trajectories. These hydrodynamic...journal article 2020
- document
-
Mastrangeli, Massimo (author), Millet, Sylvie (author), ORCHID partners, the (author), van den Eijnden-van Raaij, Janny (author)Organ-on-Chip is considered a potentially game-changing technology born from the convergence of tissue engineering and microfluidic technology. Organ-on-Chip devices (OoCs) are expected to offer effective solutions to persisting problems in drug development and personalized disease treatments. This opinion paper surveys the current landscape in...journal article 2019