Extracellular and intracellular effects of bioactive glass nanoparticles on osteogenic differentiation of bone marrow mesenchymal stem cells and bone regeneration in zebrafish osteoporosis model

Bioactive glass nanoparticles (BGNs) are well-recognized multifunctional biomaterials for bone tissue regeneration due to their capability to stimulate various cellular processes through released biologically active ions. Understanding the correlation between BGN composition and cellular responses is key to developing clinically usable BGN...

Synergistic effects of cerium-containing bioactive glasses and apoptotic extracellular vesicles alleviate bisphosphonate-related osteonecrosis of jaw

Bisphosphonates (BPs) are commonly used to treat skeletal diseases. However, long-term use of BPs can lead to BP-related jaw bone necrosis (BRONJ), particularly in patients undergoing tooth extraction surgery. The treatment of BRONJ remains challenging due to the local inflammatory microenvironment. To address this issue, we developed...

Engineered biochemical cues of regenerative biomaterials to enhance endogenous stem/progenitor cells (ESPCs)-mediated articular cartilage repair

As a highly specialized shock-absorbing connective tissue, articular cartilage (AC) has very limited self-repair capacity after traumatic injuries, posing a heavy socioeconomic burden. Common clinical therapies for small- to medium-size focal AC defects are well-developed endogenous repair and cell-based strategies, including microfracture,...

Groundwater Vulnerability in a Megacity Under Climate and Economic Changes: A Coupled Sociohydrological Analysis

Groundwater depletion has become increasingly challenging, and many cities worldwide have adopted drastic policies to relieve water stress due to socioeconomic growth. Located on the declining aquifer of the North China Plain, Beijing, for example, has developed plans to limit the size of the city’s population. However, the effect of...

Damage pattern recognition for corroded beams strengthened by CFRP anchorage system based on acoustic emission techniques

This study presents a damage pattern recognition approach for corroded steel beams strengthened by CFRP anchorage system based on acoustic emission clustering analysis. The proposed method includes four steps: acoustic emission signal acquisition, feature extraction, clustering analysis, and damage pattern recognition. Four corroded beams...

DEKS: A Secure Cloud-Based Searchable Service Can Make Attackers Pay

Many practical secure systems have been designed to prevent real-world attacks via maximizing the attacking cost so as to reduce attack intentions. Inspired by this philosophy, we propose a new concept named delay encryption with keyword search (DEKS) to resist the notorious keyword guessing attack (KGA), in the context of secure cloud-based...

Long-lived charge separation following pump-wavelength–dependent ultrafast charge transfer in graphene/WS₂ heterostructures

Van der Waals heterostructures consisting of graphene and transition metal dichalcogenides have shown great promise for optoelectronic applications. However, an in-depth understanding of the critical processes for device operation, namely, interfacial charge transfer (CT) and recombination, has so far remained elusive. Here, we investigate...

First demonstration of l-band high-power limiter with gan schottky barrier diodes (Sbds) based on steep-mesa technology

Gallium nitride (GaN) has attracted increased attention because of superior material properties, such as high electron saturation velocity and high electrical field strength, which are promising for high-power microwave applications. We report on a high-performance vertical GaN-based Schottky barrier diode (SBD) and its demonstration in a...

High-power and broadband microwave detection with a quasi-vertical GaN Schottky barrier diode by novel post-mesa nitridation

We report a high-performance GaN Schottky barrier diode (SBD) on a sapphire substrate with a novel post-mesa nitridation technique and its application in a high-power microwave detection circuit. The fabricated SBD achieved a very high forward current density of 9.19 kA cm-2 at 3 V, a low specific on-resistance (RON,sp) of 0.22 mO cm2 and...