Dealing With Uncertainty in Early Health Technology Assessment: An Exploration of Methods for Decision Making Under Deep Uncertainty

Objectives: In early stages, the consequences of innovations are often unknown or deeply uncertain, which complicates early health economic modeling (EHEM). The field of decision making under deep uncertainty uses exploratory modeling (EM) in situations when the system model, input probabilities/distributions, and consequences are unknown or...

Accounting for the uncertain effects of hydraulic interactions in optimising embankments heights: Proof of principle for the IJssel River

Most alluvial plains in the world are protected by flood defences, for example, embankments, whose primary aim is to reduce the probability of flooding of the protected areas. At the same time, however, the presence of embankments at one area influences hydraulic conditions of downstream areas located on the same river. These hydraulic...