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4D printed shape-shifting biomaterials for tissue engineering and regenerative medicine applicationsKalogeropoulou, Maria (author), Diaz Payno, P.J. (author), Mirzaali, Mohammad J. (author), van Osch, G.J.V.M. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)The existing 3D printing methods exhibit certain fabrication-dependent limitations for printing curved constructs that are relevant for many tissues. Four-dimensional (4D) printing is an emerging technology that is expected to revolutionize the field of tissue engineering and regenerative medicine (TERM). 4D printing is based on 3D printing,...review 2024
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Eijkel, B.I.M. (author), Apachitei, I. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)The antibacterial biofunctionality of bone implants is essential for the prevention and treatment of implant-associated infections (IAI). In vitro co-culture models are utilized to assess this and study bacteria-host cell interactions at the implant interface, aiding our understanding of biomaterial and the immune response against IAI without...review 2024
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van Hengel, I.A.J. (author), Tierolf, M.W.A.M. (author), Fratila-Apachitei, E.L. (author), Apachitei, I. (author), Zadpoor, A.A. (author)Patients receiving orthopedic implants are at risk of implant-associated infections (IAI). A growing number of antibiotic-resistant bacteria threaten to hamper the treatment of IAI. The focus has, therefore, shifted towards the development of implants with intrinsic antibacterial activity to prevent the occurrence of infection. The use of Ag, Cu...review 2021
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Salandova, M. (author), van Hengel, I.A.J. (author), Apachitei, I. (author), Zadpoor, A.A. (author), van der Eerden, B.C.J. (author), Fratila-Apachitei, E.L. (author)Aseptic loosening of a permanent prosthesis remains one of the most common reasons for bone implant failure. To improve the fixation between implant and bone tissue as well as enhance blood vessel formation, bioactive agents are incorporated into the surface of the biomaterial. This study reviews and compares five bioactive elements (copper,...review 2021
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Honig, Floris (author), Vermeulen, Steven (author), Zadpoor, A.A. (author), de Boer, Jan (author), Fratila-Apachitei, E.L. (author)The ability to control the interactions between functional biomaterials and biological systems is of great importance for tissue engineering and regenerative medicine. However, the underlying mechanisms defining the interplay between biomaterial properties and the human body are complex. Therefore, a key challenge is to design biomaterials that...review 2020
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Callens, S.J.P. (author), Uyttendaele, Rafael J.C. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)Recent evidence clearly shows that cells respond to various physical cues in their environments, guiding many cellular processes and tissue morphogenesis, pathology, and repair. One aspect that is gaining significant traction is the role of local geometry as an extracellular cue. Elucidating how geometry affects cell and tissue behavior is,...review 2020
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Modaresifar, K. (author), Azizian Amiri, S. (author), Ganjian, M. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)We systematically reviewed the currently available evidence on how the design parameters of surface nanopatterns (e.g. height, diameter, and interspacing) relate to their bactericidal behavior. The systematic search of the literature resulted in 46 studies that satisfied the inclusion criteria of examining the bactericidal behavior of...review 2019
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Sarkiri, Maria (author), Fox, Stephan C. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)Clinical use of bioengineered skin in reconstructive surgery has been established for more than 30 years. The limitations and ethical considerations regarding the use of animal models have expanded the application of bioengineered skin in the areas of disease modeling and drug screening. These skin models should represent the anatomical and...review 2019