Subaqueous dilative slope failure (breaching): Current understanding and future prospects

This article presents the current state-of-the-art understanding of underwater dilative slope failure (breaching). Experimental investigations are reviewed, providing critical insights into the underlying physics of breaching and pointing out knowledge gaps, which underscore the need for further research. Besides, field observations at several...

Human C-reactive protein aggravates osteoarthritis development in mice on a high-fat diet

Objective: C-reactive protein (CRP) levels can be elevated in osteoarthritis (OA) patients. In addition to indicating systemic inflammation, it is suggested that CRP itself can play a role in OA development. Obesity and metabolic syndrome are important risk factors for OA and also induce elevated CRP levels. Here we evaluated in a human CRP ...

Fib3-3 as a biomarker for osteoarthritis in a rat model with metabolic dysregulation

Objective: Fibulin-3 is a glycoprotein highly expressed in osteoarthritic cartilage and inhibits angiogenesis and chondrocyte differentiation. Recent studies have indicated that fibulin-3 has potential value as a biomarker in osteoarthritis. The aim of the present study is to examine the role of 3 fibulin-3 peptides (Fib3-1, Fib3-2, and Fib3...

Local and systemic inflammatory lipid profiling in a rat model of osteoarthritis with metabolic dysregulation

Objective Bioactive oxidised lipids (oxylipins) are important signalling mediators, capable of modulating the inflammatory state of the joint and anticipated to be of importance in joint homeostasis and status of osteoarthritis. The aim of this study was to quantify oxylipin levels in plasma and synovial fluid from rats with experimentally...

Imaging of folate receptor expressing macrophages in the rat groove model of osteoarthritis: Using a new DOTA-folate conjugate

Objective. To evaluate the presence and localization of folate receptor expressing macrophages in the rat groove model of osteoarthritis and determine the suitability of a new folate conjugate with albumin-binding entity (cm09) for in vivo SPECT (single-photon emission computed tomography) analysis. Design. In male Wistar rats, local cartilage...

Groove model of tibia-femoral osteoarthritis in the rat

Several experimental models of osteoarthritis in rats are used to study the pathophysiology of osteoarthritis. Many mechanically induced models have the limitation that permanent joint instability is induced by, for example, ligament transection or meniscal damage. This permanent instability will counteract the potential beneficial effects of...

Oeverstabiliteit bij verdieping waterbodems: Rekenmodel HMBreach

Dit rapport betreft de eindrapportage van Delft Cluster project WP 04 43 11, Stabiliteit Oevers bij verdieping Waterbodem, in Ontwikkeling Wetlands, dat vier jaar heeft gelopen en thans is afgerond met budgetten in het kader van BSIK en eigen “matching” speurwerk van Deltares. In het verleden is in het kader van het onderzoek Storten van Zand...

Oeverstabiliteit in zandwinputten: Rekenmodel HMBreach

In de “Blik op de toekomst” van de CUR commissie C130 is gesteld dat kennisontwikkeling in de komende jaren zich zou moeten richten op de volgende doeleinden: - verbetering van de kwantificering van de invloed van baggermaterieel en baggermethode op de taludvorming, dus ook op de inscharing, als functie van de grondopbouw, waardoor onzekerheden...

Numerical modelling of slope formation with sand mining