Whole-cell modeling in yeast predicts compartment-specific proteome constraints that drive metabolic strategies

When conditions change, unicellular organisms rewire their metabolism to sustain cell maintenance and cellular growth. Such rewiring may be understood as resource re-allocation under cellular constraints. Eukaryal cells contain metabolically active organelles such as mitochondria, competing for cytosolic space and resources, and the nature of...

Cross-shore intertidal bar behavior along the dutch coast: Laser measurements and conceptual model

Intertidal bars are naturally occurring morphological features along the waterline of sandy beaches. Present quantitative knowledge on intertidal bar behavior is limited, due to the scarcity of data resources and the limitations of traditional survey techniques. To investigate and quantify the cross-shore morphologic behavior of intertidal...

A proteome-integrated, carbon source dependent genetic regulatory network in: Saccharomyces cerevisiae

Integrated regulatory networks can be powerful tools to examine and test properties of cellular systems, such as modelling environmental effects on the molecular bioeconomy, where protein levels are altered in response to changes in growth conditions. Although extensive regulatory pathways and protein interaction data sets exist which...

Applicability of video-derived bathymetry estimates to nearshore current model predictions

In the framework of swimmer safety, coastal managers desire accurate nearshore current predictions obtained from numerical models. To this end, detailed and up-to-date bathymetry is a necessity. Remote sensing techniques for bathymetry estimation are a promising solution. The focus of this paper is to assess the performance of wavenumberbased...

Monitoring morphology of the sand engine leeside using Argus' cBathy

The Sand Engine is a mega-nourishment constructed in 2011 with the purpose of replenishing the surrounding southern Dutch coast by exploiting the strength of local alongshore currents for the next 20 years. Long term monitoring of the Sand Engine depends upon remote sensing coupled with in-situ measurements due to both its large spatial and...

Quantifying nearshore morphological recovery time scales using argus video imaging: Palm Beach, Sydney and Duck, North Carolina

Time scales of post-storm nearshore morphological recovery and physical processes governing these time scales are poorly understood at present. The ability to predict nearshore morphological recovery time scales based on pre-, during- or post-resetting storm conditions is an essential requirement for building and validating scale aggregated...

Insulator to correlated metal transition in V1?xMoxO2

Although many materials display the transition from insulating to metallic behavior on doping, only a few, such as VO2, have the right combination of crystal structure and physical properties to serve as model systems. Here we report the electronic and structural characteristics of the insulator to metal transition in V1?xMoxO2, which we have...

XY displacement device

An XY-displacement device (1) with a four-fold symmetry comprises a reference frame (10); an object mount (20) for holding an object (22) to be displaced; an X-manipulator (100) coupled between the reference frame (10) and the object mount (20), which provides a rigid coupling between the object mount (20) and a piezoelectric X-actuator (140),...

A novel scanning tunneling microscope with inherent scan linearization

Bewoners houden toezicht in Falgabuurt

Deze evaluatie is het produkt van een samenwerking tussen Nieuw Den Helder Plus en het Onderzoeksinstituut voor Technische Bestuurskunde (OTB). Het OTB verricht in opdracht van de (inmiddels opgeheven) Stuurgroep Bestuurlijke Preventie van Criminaliteit een onderzoek genaamd 'Kleine criminaliteit en naoorlogse etagebouw'. Doel van dit onderzoek...