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van der Sluis, Tetje C. (author), Beyrend, Guillaume (author), van der Gracht, Esmé T.I. (author), Abdelaal, T.R.M. (author), Jochems, Simon P. (author), Belderbos, Robert A. (author), Wesselink, Thomas H. (author), van Duikeren, Suzanne (author), Arens, Ramon (author)Immune checkpoint therapy (ICT) has the power to eradicate cancer, but the mechanisms that determine effective therapy-induced immune responses are not fully understood. Here, using high-dimensional single-cell profiling, we interrogate whether the landscape of T cell states in the peripheral blood predict responses to combinatorial targeting...journal article 2023
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Pardieck, Iris N. (author), van der Sluis, Tetje C. (author), van der Gracht, Esmé T.I. (author), Veerkamp, Dominique M.B. (author), Behr, Felix M. (author), van Duikeren, Suzanne (author), Beyrend, Guillaume (author), Rip, Jasper (author), Abdelaal, T.R.M. (author)Understanding the mechanisms and impact of booster vaccinations are essential in the design and delivery of vaccination programs. Here we show that a three dose regimen of a synthetic peptide vaccine elicits an accruing CD8<sup>+</sup> T cell response against one SARS-CoV-2 Spike epitope. We see protection against lethal SARS-CoV-2 infection...journal article 2022
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Maan, R. (author), Reese, L. (author), Volkov, V. (author), King, M.R. (author), van der Sluis, E.O. (author), Andrea, N. (author), Evers, W.H. (author), Jakobi, A. (author), Dogterom, A.M. (author)Growing microtubule ends organize end-tracking proteins into comets of mixed composition. Here using a reconstituted fission yeast system consisting of end-binding protein Mal3, kinesin Tea2 and cargo Tip1, we found that these proteins can be driven into liquid-phase droplets both in solution and at microtubule ends under crowding conditions....journal article 2022
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Fragasso, A. (author), de Vries, Hendrik W. (author), Andersson, John (author), van der Sluis, E.O. (author), van der Giessen, Erik (author), Onck, Patrick R. (author), Dekker, C. (author)Nuclear pore complexes (NPCs) regulate all molecular transport between the nucleus and the cytoplasm in eukaryotic cells. Intrinsically disordered Phe-Gly nucleoporins (FG-Nups) line the central conduit of NPCs to impart a selective barrier where large proteins are excluded unless bound to a transport receptor (karyopherin; Kap). Here, we...journal article 2022
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Fragasso, A. (author), de Vries, Hendrik W. (author), Andersson, John (author), van der Sluis, E.O. (author), van der Giessen, Erik (author), Dahlin, Andreas (author), Onck, Patrick R. (author), Dekker, C. (author)Nuclear Pore Complexes (NPCs) regulate bidirectional transport between the nucleus and the cytoplasm. Intrinsically disordered FG-Nups line the NPC lumen and form a selective barrier, where transport of most proteins is inhibited whereas specific transporter proteins freely pass. The mechanism underlying selective transport through the NPC is...journal article 2021
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Fragasso, A. (author), De Franceschi, N. (author), Stömmer, Pierre (author), van der Sluis, E.O. (author), Dietz, Hendrik (author), Dekker, C. (author)Molecular traffic across lipid membranes is a vital process in cell biology that involves specialized biological pores with a great variety of pore diameters, from fractions of a nanometer to >30 nm. Creating artificial membrane pores covering similar size and complexity will aid the understanding of transmembrane molecular transport in...journal article 2021
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Ryu, J.K. (author), Katan, A.J. (author), van der Sluis, E.O. (author), Wisse, T. (author), de Groot, Ralph (author), Haering, Christian H. (author), Dekker, C. (author)An amendment to this paper has been published and can be accessed via a link at the top of the paper.journal article 2020
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Spoelstra, W.K. (author), van der Sluis, E.O. (author), Dogterom, A.M. (author), Reese, L. (author)Coacervates are polymer-rich droplets that form through liquid-liquid phase separation in polymer solutions. Liquid-liquid phase separation and coacervation have recently been shown to play an important role in the organization of biological systems. Such systems are highly dynamic and under continuous influence of enzymatic and chemical...journal article 2020
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Hichert, M. (author), Abbink, D.A. (author), Vardy, A.N. (author), van der Sluis, Corry K. (author), Janssen, Wim G.M. (author), Brouwers, Michael A.H. (author), Plettenburg, D.H. (author)Operating a body-powered prosthesis can be painful and tiring due to high cable operation forces, illustrating that low cable operation forces are a desirable design property for body-powered prostheses. However, lower operation forces might negatively affect controllability and force perception, which is plausible but not known. This study...journal article 2019
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Khalilnezhad, H. (author), Popov, M. (author), Bos, Jorrit A. (author), de Jong, JPW (author), van der Sluis, L. (author)Switching operations in power systems can produce significant overvoltages under specific circumstances. With the increasing application of underground cables in transmission systems, the statistical distribution of energization overvoltages is expected to change substantially due to the different electrical characteristics of cables and OHLs....conference paper 2018
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Khalilnezhad, H. (author), Popov, M. (author), van der Sluis, L. (author), Bos, Jorrit A. (author), Ametani, Akihiro (author)Energization overvoltages are among the severest overvoltages stressing insulations of EHV power system components. Since these overvoltages have a statistical nature, the insulation level should be determined with the use of a statistical approach by which the distribution of overvoltages is calculated. Literature has properly studied the...journal article 2018
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Khalilnezhad, H. (author), Popov, M. (author), van der Sluis, L. (author), Bos, Jorrit A. (author), de Jong, Jan P.W. (author), Ametani, Akihiro (author)Zero-missing is a phenomenon in shunt compensated cable systems in which the current through the line breaker does not cross the zero point for several cycles. This paper deals with a thorough investigation on countermeasures of the zero-missing phenomenon in transmission systems and determines the requirements, benefits, and risks of...journal article 2018
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Khalilnezhad, H. (author), Chen, S. (author), Popov, M. (author), Bos, J.A. (author), de Jong, J.P.W. (author), van der Sluis, L. (author)This paper deals with the shunt compensation design of long 380kV-50Hz XLPE cables by simulating a double-circuit partially cabled connection with the transmission length of 80km in the Dutch transmission system. The proposed procedure for shunt compensation sizing is fully elaborated in this paper. Four sizing criteria are used to find the...conference paper 2016
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Huinnk, L.H.B. (author), Bouwsema, H. (author), Plettenburg, D.H. (author), van der Sluis, C.K. (author), Bongers, R.M. (author)Background: Little is known about action-perception learning processes underlying prosthetic skills in body-powered prosthesis users. Body-powered prostheses are controlled through a harness connected by a cable that might provide for limited proprioceptive feedback. This study aims to test transfer of training basic tasks to functional tasks...journal article 2016
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Popov, M. (author), Smeets, RPP (author), van der Sluis, L. (author), de Herdt, H (author), Declercq, J (author)Abstract The work presented in this paper deals with the investigation of circuit breaker prestrike effect that occurs during energizing a distribution transformer. An experimental test setup that consists of a supply transformer, a vacuum circuit breaker (VCB), a cable and a test transformer is built, and the prestrikes in the VCB are recorded....journal article 2009
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- Popov, M. (author), van der Sluis, L. (author), Smeets, R.P.P. (author) conference paper 2007
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- Popov, M. (author), van der Sluis, L. (author), Smeets, R.P.P. (author), Terzija, V.V. (author) conference paper 2007
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- Popov, M. (author), Grcev, L. (author), van der Sluis, L. (author), Terzija, V.V. (author) journal article 2005
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- van Lanen, E.P.A. (author), Popov, M. (author), van der Sluis, L. (author), Smeets, R.P.P. (author) journal article 2005
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- Popov, M. (author), van der Sluis, L. (author), Paap, G.C. (author), De Herdt, H. (author) journal article 2003
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