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Rivera-Arbeláez, José M. (author), Keekstra, Danjel (author), Cofiño-Fabres, Carla (author), Boonen, Tom (author), Dostanic, M. (author), ten Den, Simone A. (author), Vermeul, Kim (author), Mastrangeli, Massimo (author), van den Berg, A (author)The high rate of drug withdrawal from the market due to cardiovascular toxicity or lack of efficacy, the economic burden, and extremely long time before a compound reaches the market, have increased the relevance of human in vitro models like human (patient-derived) pluripotent stem cell (hPSC)-derived engineered heart tissues (EHTs) for the...journal article 2023
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Tawade, P. (author), Mastrangeli, Massimo (author)Demand for biocompatible, non-invasive, and continuous real-time monitoring of organs-on-chip has driven the development of a variety of novel sensors. However, highest accuracy and sensitivity can arguably be achieved by integrated biosensing, which enables in situ monitoring of the in vitro microenvironment and dynamic responses of tissues...review 2023
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Motreuil-Ragot, P.A. (author), Hunt, A. (author), Sacco, L.N. (author), Sarro, Pasqualina M (author), Mastrangeli, Massimo (author)Ionic polymer metal composites (IPMCs) are a class of materials with a rising appeal in biological micro-electromechanical systems (bio-MEMS) due to their unique properties (low voltage output, bio-compatibility, affinity with ionic medium). While tailoring and improving actuation capabilities of IPMCs is a key motivator in almost all IPMC...journal article 2023
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Windt, L. M. (author), Wiendels, M. (author), Dostanić, M. (author), Bellin, M. (author), Sarro, Pasqualina M (author), Mastrangeli, Massimo (author), Mummery, C. L. (author), van Meer, B.J. (author)Human heart tissues grown as three-dimensional spheroids and consisting of different cardiac cell types derived from pluripotent stem cells (hiPSCs) recapitulate aspects of human physiology better than standard two-dimensional models in vitro. They typically consist of less than 5000 cells and are used to measure contraction kinetics although...journal article 2023
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Aydogmus, H. (author), Hu, M. (author), Ivancevic, Lovro (author), Frimat, Jean Philippe (author), van den Maagdenberg, Arn M.J.M. (author), Sarro, Pasqualina M (author), Mastrangeli, Massimo (author)Continuous monitoring of tissue microphysiology is a key enabling feature of the organ-on-chip (OoC) approach for in vitro drug screening and disease modeling. Integrated sensing units are particularly convenient for microenvironmental monitoring. However, sensitive in vitro and real-time measurements are challenging due to the inherently...journal article 2023
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Dostanic, M. (author), Windt, Laura (author), Wiendels, Maury (author), van Meer, Berend J. (author), Mummery, Christine L. (author), Sarro, Pasqualina M (author), Mastrangeli, Massimo (author)We present a novel design of elastic micropillars for tissue self-assembly in engineered heart tissue (EHT) platforms. The innovative tapered profile confines reproducibly the tissue position along the main micropillar axis, increasing the accuracy of tissue contraction force measurement. Polydimethylsiloxane-based pillars were designed and...conference paper 2023
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Kasi, D.G. (author), de Graaf, M.N.S. (author), Motreuil-Ragot, P.A. (author), Frimat, Jean-Phillipe M. S. (author), Ferrari, Michel D. (author), Sarro, Pasqualina M (author), Mastrangeli, Massimo (author), van den Maagdenberg, Arn M.J.M. (author), Mummery, Christine (author), Orlova, Valeria (author)Organ-on-a-chip (OoC) and microfluidic devices are conventionally produced using microfabrication procedures that require cleanrooms, silicon wafers, and photomasks. The prototyping stage often requires multiple iterations of design steps. A simplified prototyping process could therefore offer major advantages. Here, we describe a rapid and...journal article 2022
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French, P.J. (author), Krijnen, Gijs JM (author), Vollebregt, S. (author), Mastrangeli, Massimo (author)Silicon sensors date back to before 1960 with early Hall and piezoresistive devices. These used simple processing that was part of the early integrated circuit (IC) industry. As the IC industry developed, silicon sensors could benefit from the technological advances. As silicon sensors advanced, there came the need for new technologies...journal article 2022
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Motreuil-Ragot, P.A. (author), Turcan, G. (author), de Wagenaar, B. (author), Hunt, A. (author), Sarro, Pasqualina M (author), Mastrangeli, Massimo (author)Sensing flow rates in structured microenvironments like lab-on-chip (LOC) and organ-on-chip (OoC) is crucial to assess important parameters such as transport of media and molecules of interest. So far, these micro-electromechanical systems for biology (bio-MEMS) mostly rely on flow sensing systems based on thermal sensors. However, thermal...conference paper 2022
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Revyn, N. (author), Hu, Michel H.Y. (author), Frimat, Jean-Philippe (author), de Wagenaar, B. (author), van den Maagdenberg, Arn M.J.M. (author), Sarro, Pasqualina M (author), Mastrangeli, Massimo (author)We present preliminary recordings on chip of three-dimensional (3D) electric neuronal activity from cultures of cortical neurons derived from human-induced pluripotent stem cells (hiPSCs). The recordings were obtained through 3D microelectrode arrays (MEAs) composed of truncated, 90 μm-high Si micropyramids endowed with multiple, electrically...conference paper 2022
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Wardhana, G.K. (author), Mastrangeli, Massimo (author), Lopes Marta da Costa, T.M. (author)2D phased array ultrasonic transducers realized through the combination of bulk piezoelectric ceramics and complementary metal-oxide-semiconductor (CMOS) integrated circuits (IC) are enabling a new range of wearable ultrasound therapeutic applications. Traditional therapeutic ultrasound transducers have an air backing layer to maximize...conference paper 2022
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- Revyn, N. (author), Hu, Michel (author), Frimat, Jean-Philippe (author), van den Maagdenberg, Arn M.J.M. (author), Sarro, Pasqualina M (author), Mastrangeli, Massimo (author) poster 2021
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- Aydogmus, H. (author), van Ginkel, H.J. (author), Galiti, A-D. (author), Hu, M.H.Y. (author), Frimat, J-P. (author), van den Maagdenberg, A.M.J.M. (author), Zhang, Kouchi (author), Mastrangeli, Massimo (author), Sarro, Pasqualina M (author) poster 2021
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- Rivera-Arbelaez, J.M. (author), Dostanic, M. (author), Stein, J.M. (author), van den Berg, A. (author), Segerink, L.I. (author), Mummery, C.L. (author), Sarro, Pasqualina M (author), Mastrangeli, Massimo (author), Ribeiro, M.C. (author), Passier, R. (author) poster 2021
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- Dostanic, M. (author), Windt, L.M. (author), Stein, J.M. (author), van Meer, B.J. (author), Diakou, A. (author), Mummery, C.L. (author), Sarro, Pasqualina M (author), Mastrangeli, Massimo (author) poster 2021
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Alfaro Barrantes, J.A. (author), Mastrangeli, Massimo (author), Thoen, David (author), Visser, Sten (author), Bueno Lopez, J. (author), Baselmans, J.J.A. (author), Sarro, Pasqualina M (author)This paper describes the microfabrication and electrical characterization of aluminum-coated superconducting through-silicon vias (TSVs) with sharp superconducting transition above 1 K. The sharp superconducting transition was achieved by means of fully conformal and void-free DC-sputtering of the TSVs with Al, and is here demonstrated in up...journal article 2021
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Mastrangeli, Massimo (author), van den Eijnden-van Raaij, A.J.M. (author)Organ-on-chip (OoC) technology is thriving thanks to stem cells availability and international OoC programs. Concerted standardization, qualification, and independent testing of devices are needed to coherently develop OoC technology further and fulfill its potential in drug development, disease modeling, and personalized medicine. The OoC...journal article 2021
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Aydogmus, H. (author), van Ginkel, H.J. (author), Galiti, Anna-Danai (author), Hu, Michel (author), Frimat, Jean-Philippe (author), van den Maagdenberg, Arn (author), Zhang, Kouchi (author), Mastrangeli, Massimo (author), Sarro, Pasqualina M (author)Continuous monitoring of tissue microphysiology is a key enabling feature of the organ-on-chip (OoC) approach for drug screening and disease modeling. Sensing charged species in OoC tissue microenvironments is thereby essential. However, the inherently small (i.e., cm) size of OoC devices poses the challenging requirement to integrate...conference paper 2021
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Mastrangeli, Massimo (author), Aydogmus, H. (author), Dostanic, M. (author), Motreuil-Ragot, P.A. (author), Revyn, N. (author), de Wagenaar, B. (author), Dekker, R. (author), Sarro, Pasqualina M (author)Stemming from the convergence of tissue engineering and microfluidics, organ-on-chip (OoC) technology can reproduce in vivo-like dynamic microphysiological environments for tissues in vitro. The possibility afforded by OoC devices of realistic recapitulation of tissue and organ (patho)physiology may hold the key to bridge the current...conference paper 2021
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Dostanic, M. (author), Stein, Jeroen (author), Windt, Laura (author), van Meer, Berend (author), Bellin, Milena (author), Orlova, Valeria (author), Mastrangeli, Massimo (author), Mummery, Christine (author), Sarro, Pasqualina M (author)We present a wafer-scale fabricated, PDMS-based platform for culturing miniaturized engineered heart tissues (EHTs) which allows highly accurate measurements of the contractile properties of these tissues. The design of the platform is an anisometrically downscaled version of the Heart-Dyno system, consisting of two elastic micropillars inside...journal article 2020