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Enhancing spinal bone anchor pull-out resistance with an L-shaped anchor

de Kater, E.P. (author), Blom, M.N. (author), van Doorn, T.C. (author), Tieu, Q.H. (author), Jager, D.J. (author), Sakes, A. (author), Breedveld, P. (author)

The success rate of spinal fusion surgery is mainly determined by the fixation strength of the spinal bone anchors. This study explores the use of an L-shaped spinal bone anchor that is intended to establish a macro-shape lock with the posterior cortical layer of the vertebral body, thereby increasing the pull-out resistance of the anchor. The...

journal article 2024

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Quinolinium-Based Fluorescent Probes for Dynamic pH Monitoring in Aqueous Media at High pH Using Fluorescence Lifetime Imaging

Bleeker, J.J. (author), Kahn, A.P. (author), Baumgartner, L.M. (author), Grozema, F.C. (author), Vermaas, D.A. (author), Jager, W.F. (author)

Spatiotemporal pH imaging using fluorescence lifetime imaging microscopy (FLIM) is an excellent technique for investigating dynamic (electro)chemical processes. However, probes that are responsive at high pH values are not available. Here, we describe the development and application of dedicated pH probes based on the 1-methyl-7-amino...

journal article 2023

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Direct Imaging of Local pH Reveals Bubble-Induced Mixing in a CO₂ Electrolyzer

Baumgartner, L.M. (author), Kahn, A.P. (author), Hoogland, Maxime (author), Bleeker, J.J. (author), Jager, W.F. (author), Vermaas, D.A. (author)

Electrochemical CO₂ reduction poses a promising pathway to produce hydrocarbon chemicals and fuels without relying on fossil fuels. Gas diffusion electrodes allow high selectivity for desired carbon products at high current density by ensuring a sufficient CO₂ mass transfer rate to the catalyst layer. In addition to CO...

journal article 2023

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Editorial: Tipping points in societies

Kurahashi, Setsuya (author), Chappin, E.J.L. (author), Jager, Wander (author), Takahashi, Hiroshi (author)

contribution to periodical 2023

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Tuning the Driving Force for Charge Transfer in Perovskite-Chromophore Systems

Wei, Z. (author), Mulder, J.T. (author), Dubey, R. (author), Evers, W.H. (author), Jager, W.F. (author), Houtepen, A.J. (author), Grozema, F.C. (author)

Understanding the interplay between the kinetics and energetics of photophysical processes in perovskite-chromophore hybrid systems is crucial for realizing their potential in optoelectronics, photocatalysis, and light-harvesting applications. By combining steady-state optical characterizations and transient absorption spectroscopy, we have...

journal article 2023

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MemoBox: A mechanical follow-the-leader system for minimally invasive surgery

Culmone, C. (author), Jager, D.J. (author), Breedveld, P. (author)

With the increase in Natural Orifice Transluminal Endoscopic Surgery procedures, there is an increasing demand for surgical instruments with additional degrees of freedom, able to travel along tortuous pathways and guarantee dexterity and high accuracy without compromising the surrounding environment. The implementation of follow-the-leader...

journal article 2022

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Patient-derived breast model repository, a tool for hyperthermia treatment planning and applicator design

Androulakis, Ioannis (author), Sumser, Kemal (author), Machielse, Melanie N.D. (author), Koppert, Linetta (author), Jager, Agnes (author), Nout, Remi (author), Franckena, Martine (author), van Rhoon, G.C. (author), Curto, Sergio (author)

Objective: The addition of hyperthermia in the treatment of intact breast cancer with the aim to improve local response is currently in a research phase. First, optimal hyperthermia devices need to be developed, for which a diverse, anatomically and pathologically accurate set of patient models is necessary. Methods: To investigate the...

journal article 2022

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Fast Charge Separation in Distant Donor-Acceptor Dyads Driven by Relaxation of a Hot Excited State

Wei, Z. (author), Philip, A.M. (author), Jager, W.F. (author), Grozema, F.C. (author)

A series of three perylenemonoimide-p-oligophenylene-dimethylaniline molecular dyads undergo photoinduced charge separation (CS) with anomalous distance dependence as a function of increasing donor-acceptor (DA) distances. A comprehensive experimental and computational investigation of the photodynamics in the donor-bridge-acceptor (DBA)...

journal article 2022

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POD–Kalman filtering for improving noninvasive 3D temperature monitoring in MR-guided hyperthermia

VilasBoas-Ribeiro, Iva (author), Nouwens, Sven A.N. (author), Curto, Sergio (author), Jager, Bram de (author), Franckena, Martine (author), van Rhoon, G.C. (author), Heemels, W. P.M.H. (author), Paulides, Margarethus M. (author)

Background: During resonance frequency (RF) hyperthermia treatment, the temperature of the tumor tissue is elevated to the range of 39–44°C. Accurate temperature monitoring is essential to guide treatments and ensure precise heat delivery and treatment quality. Magnetic resonance (MR) thermometry is currently the only clinical method to...

journal article 2022

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Room temperature synthesis of perylene diimides facilitated by high amic acid solubility

Kwakernaak, M.C. (author), Koel, Marijn (author), van den Berg, P.M. (author), Kelder, E.M. (author), Jager, W.F. (author)

A novel protocol for the synthesis of perylene diimides (PDIs), by reacting perylene dianhydride (PDA) with aliphatic amines is reported. Full conversions were obtained at temperatures between 20 and 60 °C, using DBU as the base in DMF or DMSO. A "green"synthesis of PDIs, that runs at higher temperatures, was developed using K2CO3 in DMSO....

journal article 2022

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Design of a Flexible Wasp-Inspired Tissue Transport Mechanism

de Kater, E.P. (author), Sakes, A. (author), Bloemberg, J. (author), Jager, D.J. (author), Breedveld, P. (author)

Tissue transport is a challenge during Minimally Invasive Surgery (MIS) with the current suction-based instruments as the increasing length and miniaturisation of the outer diameter requires a higher pressure. Inspired by the wasp ovipositor, a slender and bendable organ through which eggs can be transported, a flexible transport mechanism for...

journal article 2021

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The MemoFlex II, a non-robotic approach to follow-the-leader motion of a snake-like instrument for surgery using four predetermined physical tracks

Henselmans, P.W.J. (author), Culmone, C. (author), Jager, D.J. (author), van Starkenburg, R.I.B. (author), Breedveld, P. (author)

The fields of Minimally Invasive Surgery (MIS) and Natural Orifices Transluminal Endoscopic Surgery (NOTES) strive to reduce the level of invasiveness by entering the body through smaller incisions and natural orifices. Hyper-redundant snake-like instruments can help in this pursuit of reducing invasiveness. Such instruments can pass along...

journal article 2020

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Overcoming the exciton binding energy in two-dimensional perovskite nanoplatelets by attachment of conjugated organic chromophores

Gelvez Rueda, M.C. (author), Fridriksson, M.B. (author), Dubey, R. (author), Jager, W.F. (author), van der Stam, W. (author), Grozema, F.C. (author)

In this work we demonstrate a novel approach to achieve efficient charge separation in dimensionally and dielectrically confined two-dimensional perovskite materials. Two-dimensional perovskites generally exhibit large exciton binding energies that limit their application in optoelectronic devices that require charge separation such as solar...

journal article 2020

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Scalable Route to Electroactive and Light Active Perylene Diimide Dye Polymer Binder for Lithium-Ion Batteries

Ranque, P.G. (author), George, C. (author), Dubey, R. (author), van der Jagt, R. (author), Flahaut, Delphine (author), Fehse, M. (author), Jager, W.F. (author), Sudhölter, Ernst J. R. (author), Kelder, E.M. (author)

Developing multifunctional polymeric binders is key to the design of energy storage technologies with value-added features. We report that a multigram-scale synthesis of perylene diimide polymer (PPDI), from a single batch via polymer analogous reaction route, yields high molecular weight polymers with suitable thermal stability and minimized...

journal article 2020

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Efficacious elimination of intramolecular charge transfer in perylene imide based light-harvesting antenna molecules

Dubey, R. (author), Inan, D. (author), Philip, A.M. (author), Grozema, F.C. (author), Jager, W.F. (author)

Two light-harvesting antenna molecules were obtained by positioning naphthalene monoimide energy donors at the imide position, instead of the bay positions, of perylene imide energy acceptors. Such rational design resulted in a complete suppression of parasitic intramolecular charge transfer without compromising the desired ultrafast rates of...

journal article 2020

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Tailoring Photophysical Processes of Perylene-Based Light Harvesting Antenna Systems with Molecular Structure and Solvent Polarity

Inan, D. (author), Dubey, R. (author), Jager, W.F. (author), Grozema, F.C. (author)

The excited-state dynamics of perylene-based bichromophoric light harvesting antenna systems has been tailored by systematic modification of the molecular structure and by using solvents of increasing polarity in the series toluene, chloroform, and benzonitrile. The antenna systems consist of blue light absorbing naphthalene monoimide (NMI)...

journal article 2019

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Perylene Bisimide Dyes with up to Five Independently Introduced Substituents: Controlling the Functionalization Pattern and Photophysical Properties Using Regiospecific Bay Substitution

Dubey, R. (author), Eustace, S.J. (author), Van Mullem, Jesse S. (author), Sudhölter, Ernst J. R. (author), Grozema, F.C. (author), Jager, W.F. (author)

We report herein a versatile and user-friendly synthetic methodology based on sequential functionalization that enables the synthesis of previously unknown perylene bisimide (PBI) dyes with up to five different substituents attached to the perylene core (e.g., compound 15). The key to the success of our strategy is a highly efficient...

journal article 2019

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Quantifying the Precision of Single-Molecule Torque and Twist Measurements Using Allan Variance

van Oene, M.M. (author), Ha, S. (author), Jager, T. (author), Lee, M. (author), Pedaci, F. (author), Lipfert, J. (author), Dekker, N.H. (author)

Single-molecule manipulation techniques have provided unprecedented insights into the structure, function, interactions, and mechanical properties of biological macromolecules. Recently, the single-molecule toolbox has been expanded by techniques that enable measurements of rotation and torque, such as the optical torque wrench (OTW) and...

journal article 2018

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Control design and optimization for the DOT500 hydraulic wind turbine

Mulders, S.P. (author), Jager, Stéphane (author), Diepeveen, N.F.B. (author), van Wingerden, J.W. (author)

The drivetrain of most wind turbines currently being deployed commercially consists of a rotor-gearboxgenerator configuration in the nacelle. This abstract introduces the control system design and optimization for a wind turbine with a hydraulic drivetrain, based on the Delft Offshore Turbine (DOT) concept1 . This concept enables the connection...

abstract 2017

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Substitution Effects on the Photoinduced Charge-Transfer Properties of Novel Perylene-3,4,9,10-tetracarboxylic Acid Derivatives

Inan, D. (author), Dubey, R. (author), Westerveld, N. (author), Bleeker, J.J. (author), Jager, W.F. (author), Grozema, F.C. (author)

We report here the synthesis and photophysical study of a series of electron donor–acceptor molecules, in which electron-donating 4-methoxyphenoxy groups are attached to the 1,7-bay positions of four different perylene tetracarboxylic acid derivatives, namely, perylene tetraesters 1, perylene monoimide diesters 2, perylene bisimides 3, and...

journal article 2017