Selective oxyfunctionalisation reactions catalysed by P450 monooxygenases and peroxygenases – A bright future for sustainable chemical synthesis

Heme-dependent oxygenases (i.e. P450 monooxygenases and peroxygenases) are highly selective catalysts for the selective oxyfunctionalisation or organic compounds. Both enzyme classes exhibit mechanistic similarities (i.e. using so-called compound I (CpdI) as active oxidation species) and differences in how CpdI is formed. From the differences...

Hydrogen peroxide driven biocatalysis

In general, hydrogen peroxide is a stable and relatively mild oxidant and it can be regarded as the ultimate "green" reagent because water and oxygen are the only by-products. Besides the direct application of H₂O₂ in chemical processes more and more enzymatic syntheses based on hydrogen peroxide were developed....