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Barth, R. (author)
Genetic information encoded in the DNA sequences is maintained, replicated, and transcribed across the tree of life. Organisms evolved multiple hierarchical layers of chromosome organization which ensure that DNA can be contained but also processed within individual cells. This thesis focuses on SMC (Structural Maintenance of Chromosomes)...
doctoral thesis 2024
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Kuhm, T.I. (author)
doctoral thesis 2024
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Tišma, M. (author)
This thesis explores the mechanisms that underlie chromosome organization in bacteria. Bacteria are considered amongst the simplest living organisms on our planet. They lack the cellular organization found in other domains of life (Archaea or Eukaryotics) and often have simpler life cycles. Over the past decade, we gained increasing knowledge...
doctoral thesis 2024
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Amini Hounejani, R. (author)
The past decades have seen the rapid development of many aspects of synthetic biology. For example, attempts to build synthetic cells under controlled conditions in the laboratory have led to significant achievements. Following a bottom-up approach, scientists aim at building a self-reproducing synthetic cell with a minimum number of biological...
doctoral thesis 2023
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Blanch Jover, A. (author)
All living organisms share the need to replicate and proliferate to ensure the survival of their species. In prokaryotes, this is generally guaranteed by a process of cell division where a mother cell is split into two equally sized daughter cells, and it is a complex and heterogeneous process across all the different species. When looking into...
doctoral thesis 2022
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Alkemade, C. (author)
The human body is composed of about 3−4×1013 (30-40 trillion) cells [1]. These cells are all functioning consistently, and working elegantly together, to sustain the organism. Not only humans, but all other living things on earth (from plants to parrots) are composed of cells. Cells are the smallest living building blocks of plants and animals,...
doctoral thesis 2021
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Blanken, D.M. (author)
Cells, the building blocks of life, are vastly complex. This complexity confers to every living organism the ability to maintain oneself, reproduce oneself, and evolve. Creating a minimal system from nonliving components that is capable of self-maintenance, self-reproduction, and evolvability, will greatly increase our understanding of life....
doctoral thesis 2021
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Imholz, N.C.E. (author)
This thesis is about a little molecule called guanosine tetraphosphate. ppGpp. Consider it the bacterial brain, at the core of the coordination and regulation of bacterial growth. For over half a century, it has haunted microbiologists as it appears involved in every aspect of microbial physiology, yet incredibly difficult to study due to its...
doctoral thesis 2020
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Vendel, K.J.A. (author)
Every living organism consists of cells. Even for the simplest single-cell organism, this cell is extremely complex. Thousands of components (such asDNA, cytoskeletal filaments, proteins, lipids, nutrients and energy) are organized both spatially and temporally to ensure proper functioning of vital cellular processes. One of those processes is...
doctoral thesis 2020
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Dang, Y. (author)
How a system of genetically identical biological cells organizes into spatially heterogeneous tissues is a central question in biology. Even when the molecular and genetic underpinnings of cell-cell interactions are known, how these lead to multicellular patterns is often poorly understood. Of particular interest are dynamic patterns such as...
doctoral thesis 2020
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Kattan, J.M. (author)
Humanity has achieved to decipher the most fundamental mechanics of cellular life. Nevertheless, despite intense efforts there are still considerable gaps in our understanding of cellular processes. Traditionally, biologists investigate life by observation of existing lifeforms. In order to assign functions to biological components, it is common...
doctoral thesis 2020
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Daalman, W.K. (author)
One of the biggest scientific challenges to be tackled this century is how traits of living organisms originate from genes, the so-called genotype-phenotype map, and conversely how traits influence genes through a process called evolution. The solution will yield a large societal impact, with applications in food (e.g., engineering drought...
doctoral thesis 2020
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Noguera López, J. (author)
The creation of artificial cells with the minimal set of components to exhibit self-maintenance, self-reproducibility and evolvability (in other words, to be considered alive) is one of the most exciting areas within the field of synthetic biology. Such entities, here called minimal cells, are constructed by either the top-down or bottom-up...
doctoral thesis 2019
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Soler Canton, A. (author)
Synthetic biology is an emerging and rapidly expanding field of research focused on the assembly of novel biological systems with new functionalities tailored for different applications. Genetic circuits have been re-wired or constructed with elements from different organisms, and metabolic pathways have been engineered to endow cells with non...
doctoral thesis 2019
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Kok, M.W.A. (author)
The microtubule cytoskeleton is an intracellular polymer network involved in cell shape, cell motility, and cell division. Microtubules are self-assembling, dynamic polymers composed of tubulin proteins that alternate between phases of growth and shrinkage, a behaviour known as “dynamic instability”. A key feature of microtubules is their...
doctoral thesis 2019
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Shomar Monges, H. (author)
For millennia, humans have used microbes to produce industrial products of social and economical value through fermentation processes. In recent years, the application of engineering principles to microbiology have dramatically expanded our ability to modify and optimize microbes for the production of a wide variety of commercial products from...
doctoral thesis 2019
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Vahid Belarghou, A. (author)
Biological membranes are selective soft barriers that compartmentalize internal structure of a cell into organelles and separate them as a whole from the external environment. Due to their innate feature of being able to undergo constant reshaping, cellular membranes spatially attain diverse shapes ranging from simple spherical vesicles to more...
doctoral thesis 2018
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van Drongelen, R. (author)
doctoral thesis 2018
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Flohr, R.C.E. (author)
doctoral thesis 2017
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Taberner Carretero, N. (author)
In this thesis we took the challenge to in vitro reconstitute a minimal phenomenon essential for live: Cell polarity. This is an ubiquitous phenomenon that allows cells to define a direction for migration, growth or division. Our study focussed on microtubulebased establishment of polarity taking S. pombe as a model organism. In this rod-shaped...
doctoral thesis 2016
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