Beamlet and energy layer reduction in IMPT by sparsity induced optimisation

In Intensity Modified Proton Therapy, the number of energy layers and the number of beamlets determine the radiation time and the plan calculation time. The purpose of this research project is to test sparsity inducing terms to reduce both the energy layers and the beamlets.

Probabilistic Treatment Planning with Polynomial Chaos Expansion for Proton Therapy

Radiotherapy is an important treatment type for patients with cancer. An advantage of state of the art proton therapy with respect to traditional photon therapy is the spatial energy deposition of protons, which is characterized by the Bragg peak. Due to this particular course of energy deposition, the tumor can be irradiated more precisely and...

Working towards a fast prompt gamma emission simulator based on the Boltzmann Equation

Range verification based on prompt gamma detection is an important step to improve dose control for proton therapy. To deduce the proton range from the detected prompt gamma emission, a prediction of the measured profile is required. This study introduces the Boltzmann solver as a faster alternative to the Monte Carlo simulations to produce dose...

Automated Treatment Planning in HDR Brachytherapy for Prostate Cancer

Introduction: High Dose Rate (HDR) Brachytherapy is a radiotherapy modality that involves temporarily introducing a highly radioactive source into the target volume with the use of an applicator. With respect to HDR brachytherapy for prostate cancer, an 192Iridium source is driven into the target volume through catheters implanted into the...

Spectral rehomogenization of cross sections for pin-by-pin nodal diusion calculations

Equivalent cross sections used in few-group nodal diffusion calculations are ob- tained through homogenization of fossile unit cells under infinite medium con- ditions. Reference reaction rates can be accurately reproduced in nodal calcu- lations provided that these unit cells are surrounded by cells of the same type. Large heterogeneities,...

A Discontinuous Galerkin Method for Charged Particle Transport in the Fokker-Planck Limit

A numerical scheme is presented for steady-state, mono-energetic charged particle transport in the Fokker-Planck limit. The spatial domain is meshed into elements, each of which has its own angular mesh. The basis is formed by a discontinuous Galerkin method both in space and in angle. The resulting discretisation is fully arbitrarily refinable...

LDA experiments on a mixing layer

Investigation on plane turbulent two phase mixing layers serves to get insight in the mutual interaction between the behaviour of the injected gas bubbles and the turbulence of the liquid phase. An experimental setup for investigations on such a mixing layer has been built. The measuring section is 20 cm in depth, 40 cm in width, and 150 cm in...

Numerieke simulaties van een laminaire bellenkolom op basis van het two fluid model

In dit onderzoek is de stroming in een laminaire bellenkolom gesimuleerd op basis van het two fluid model. De simulaties zijn uitgevoerd door een drietal Computational Fluid Dynamics codes: de commerciële code Phoenics versie 2.0 en de research codes Tpflow en Tfc2d. In de drie CFD codes wordt gebruik gemaakt van het two fluid model. Essentieel...