Improving production of ?-lactam antibiotics by Penicillium chrysogenum: Metabolic engineering based on transcriptome analysis

In Chapters 2-5 of this thesis, the applicability of transcriptome analysis to guide metabolic engineering strategies in P. chrysogenum is explored by investigating four cellular processes that are of potential relevance for industrial production of ?-lactam antibiotics: - Regulation of secondary metabolism by the Velvet complex (Chapter 2) -...