In silico detection of variable number tandem repeats associated with Alzheimer’s disease from short-read sequencing data

Motivation: Alzheimer’s disease (AD) is a highly prevalent disease whose genetic risk factors remain largely unknown. One potential genetic risk factor is tandem repeat expansions, which have been associated with over 40 diseases, most of which affect the nervous system. Detecting VNTRs from short-read data is a challenging task, leaving many...