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Poelert, S.L. (author)
This thesis consists of two parts. The first chapter is an extensive literature survey on various models that have been used to capture thermal fluctuations of semiflexible polymers. The focus of that literature study is on analytical models (i.e. wormlike chain model) and numerical models (i.e. bead models and FE model). Similarities and...
master thesis 2011
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Bosch, H.A. (author)
The kite is modelled with the non-linear finite element method to stay close to its physical properties and represent its full non-linear flexible behaviour. The inflatable beams in the leading edge and struts are modelled with regular beam elements that represent the behaviour to reduce the amount of degrees of freedom drastically. The canopy...
master thesis 2012
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Borleffs, M.S. (author)
Worldwide yearly 800.000-1.000.000 people receive a total artificial hip. 8-9% Of all patients requires a second surgery to correct the primary arthroplasty. In more than 70% of cases, aseptic loosening is the cause for implant failure. Possible pathways leading to aseptic loosening are stress shielding and micro-motions. Stress shielding can be...
master thesis 2012
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Roels, P.L. (author)
Cam impingement appears to be an important factor in the development of early osteoarthritis (OA) of the hip. A Cam is generally diagnosed in young and active adults, already at the age of thirteen. Therefore, it has been suggested that excessive femoral loading during skeletal development might trigger the abnormal morphology. The goal of this...
master thesis 2013
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Edip, S.T. (author)
Objective: Due to avascularity, chondrocytes have poor ability to regenerate themselves which is challanging for tissue engineering to achieve full functioning cartilage. Culturing chondrocytes or cartilage tissue has been frequently perfomed by using atmospheric oxygen tensions which is hyperoxic compared to nature of healthy cartilage....
master thesis 2013
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Sanchez, P.F. (author)
The tendon is the connective tissues that attach the muscles to bones. It plays an important role in the mechanics of the articulation because the tendon transmits the tensile force from the muscle to the correspondent bone. Even though the tendons are designed to support different loading conditions, it generally accepted that mechanical...
master thesis 2013
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Rauker, J. (author)
Nanoindentation using AFM and nanoindeter was used to measure the Young's modulus of 20LP10L20-LLA40 Microspheres and Gelatin-Methacrylamide (Gelma). Three different analytical methods were used for calculating the Young's modulus of microspheres in order to compare the results and find the optimal analytical method. The Young's modulus of GelMA...
master thesis 2013
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Villamar Jorgge, J.A. (author)
In the present study, the effect of concentration, osmolality and charge of x-ray contrast agents on their diffusion and equilibrium distribution across different zones of cartilage was investigated. Full-thickness cartilage discs (Ø = 8.5 mm, n = 3) were extracted from healthy equine femoral condyle (n = 2). The diffusion of four different...
master thesis 2014
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Moerman, A.M. (author)
In this pilot study, we obtained the peri-prosthetic fibrous membrane of eleven patients undergoing hip revision surgery due to aseptic loosening. We investigated the molecular content of the tissue by real-time PCR (RT-PCR) and the structural properties by histology and confocal microscopy. Atomic force microscopy (AFM) and nanoindentation were...
master thesis 2015
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Karthik Raman, H. (author)
Chondrocyte is the only cell type which constitutes the articular cartilage, is solely responsible for the turnover of extracellular matrix composed of proteoglycans, type II collagen and water. Chondrocytes experience a unique ionic/osmotic environment, which is attributable to the polyanionic proteoglycan, which carry a high fixed negative...
master thesis 2016
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Bobbert, F.S.L. (author)
Scaffolds for bone regeneration have been investigated as bone substitutes in critical sized bone defects. It is known that the architecture of these scaffolds is important for the bone regeneration process, which depends on cell response and vascular ingrowth into the scaffold. With advanced fabrication techniques, such as selective laser...
master thesis 2016
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De Krijger, J. (author)
Meta-biomaterials are porous biomaterials created by additive manufacturing techniques such as Selective Laser Melting. These materials are built up form a repeating unit cell, resulting in a porous structure that can be applied for bone implants or prosthetics. The mechanical properties of these meta-biomaterials can be tailored by variations...
master thesis 2016
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Van Wolfswinkel, G. (author)
Introduction. Aseptic loosening is indicated as the main cause of knee implant failure. Despite all currently used techniques, it remains challenging to diagnose an aseptic loose knee implant. A promising technique to reveal aseptic loose related implant motions is inducible displacement (ID). ID measurements are used to detect implant motion...
master thesis 2016
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Andriakopoulou, C. (author)
Collagen gels hold great promise in the field of tissue engineering as collagen is highly biocompatible, biodegradable, abundant in nature and it provides an optimum environment for tissue regeneration and restoration of normal tissue function. However, collagen hydrogels have poor mechanical strength due to low collagen proportion and thus are...
master thesis 2016
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van Hengel, I.A.J. (author)
Background Due to an aging population, the incidence of total joint replacements has been increasing and is expected to double in the coming decade. Along with implantation, the incidence of implant-associated infection (IAI) has risen and forms a tremendous burden for health care. Therefore, effective preventive measures for IAI are desperately...
master thesis 2016
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Brandt, J.A.H.W. (author)
Additive manufacturing techniques like electron beam melting are promising methods for the production of patient-specific implants. Current state-of-the-art preoperative imaging and computer assisted surgery techniques allow orthopaedic surgeons to perform tumor resections with smaller surgical margins while still ensuring complete cancer...
master thesis 2016
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van Manen, T. (author)
Materials and devices with advanced functionalities often need to include functionalities such as surface features into complex 3D geometries. Precisely controlled bio-nanopatterns, printed electric components and sensors/actuators are all examples of such surface features. However, the vast majority of the refined technologies that are...
master thesis 2017
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Manjapra Varieth, D.S. (author)
The implant associated infections (IAI) have been identified as one of the primary causes of bone implant failures. A novel silver based antimicrobial surface produced on Ti6Al7Nb substrates by plasma electrolytic oxidation was developed to tackle IAI . The effect of steam, dry and Ultra Violet (photocatalytical) sterilisation on this novel...
master thesis 2017
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Kolken, Eline (author)
With the aging population growing, the increasing prevalence of osteoarthritis (OA) seems inevitable. As a result, the number of joint replacements is expected to grow substantially within the next decade. Today’s hip replacements have the potential to function for more than 20 years, but due to risk factors such as aseptic loosening, the...
master thesis 2017
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Zafeiropoulou, Katerina (author)
Degenerative disc disease (DDD) is the accelerated process of intervertebral disc decay (decrease of disc thickness, enhanced cell death, ECM damage and collagen loss etc.), accompanied with pain, as well as structural and functional failure. So far, there are no therapies that can inhibit or even reverse the degenerative progress of this...
master thesis 2017
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