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Biomarker identification for endometriosis as a target for real-time intraoperative fluorescent imaging: A new approach using transcriptomic analysis to broaden the search for potential biomarkers

Tummers, Fokkedien H.M.P. (author), Bazelmans, Maria K. (author), Jansen, F.W. (author), Blikkendaal, Mathijs D. (author), Vahrmeijer, Alexander L. (author), Kuppen, P.J.K. (author)

Intra-operative fluorescent imaging of endometriosis could help to optimize surgical treatment. Potential biomarkers to use as target for endometriosis-binding fluorescent probes were identified using a new five-phase transcriptomics-based approach to broaden the search for biomarkers. Using publicly available datasets, a differentially...

review 2023

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Sex differences in characteristics of atrial fibrillation recurrence post surgical pulmonary vein isolation

Veen, Danny (author), Verbeek, Eva C. (author), Kavousi, Maryam (author), Huigen, Jos (author), Mijnen-Schra, Annet (author), Cocchieri, Riccardo (author), Khan, Muchtiar (author), de Groot, N.M.S. (author)

Background: Prior studies demonstrated that female sex is associated with arrhythmia recurrence after endovascular pulmonary vein isolation (PVI). However, it is unknown if the sexes differ in outcome after video assisted thoracoscopic (VATS) PVI. The aim of this study was therefore to compare characteristics of recurrent AF episodes in a...

journal article 2023

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Spectroscopic optical coherence tomography at 1200 nm for lipid detection

Kuttippurath, Vivek (author), Slijkhuis, Nuria (author), Liu, Shengnan (author), van Soest, G. (author)

Significance: Spectroscopic analysis of optical coherence tomography (OCT) data can yield added information about the sample's chemical composition, along with high-resolution images. Typical commercial OCT systems operate at wavelengths that may not be optimal for identifying lipid-containing samples based on absorption features. Aim: The...

journal article 2023

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Ankle-Foot-Orthosis “Hermes” Compensates Pathological Ankle Stiffness of Chronic Stroke—A Proof of Concept

Rodriguez Hernandez, K.E. (author), de Groot, J.H. (author), Baas, Frank (author), Stijntjes, M. (author), Grootendorst, E.R.M. (author), Schiemanck, S.K. (author), van der Helm, F.C.T. (author), van der Kooij, H. (author), Mugge, W. (author)

Individuals with an upper motor neuron syndrome, e.g., stroke survivors, may have a pathological increase of passive ankle stiffness due to spasticity, that impairs ankle function and activities such as walking. To improve mobility, walking aids such as ankle-foot orthoses and orthopaedic shoes are prescribed. However, these walking aids...

journal article 2023

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Mild Stroke, Serious Problems: Limitations in Balance and Gait Capacity and the Impact on Fall Rate, and Physical Activity

Roelofs, Jolanda M.B. (author), Zandvliet, Sarah B. (author), Schut, I.M. (author), Huisinga, Anouk C.M. (author), Schouten, A.C. (author), Hendricks, Henk T. (author), de Kam, Digna (author), Aerden, Leo A.M. (author), Bussmann, J.B.J. (author), Geurts, Alexander C.H. (author), Weerdesteyn, Vivian (author)

Background: After mild stroke persistent balance limitations may occur, creating a risk factor for fear of falling, falls, and reduced activity levels. Objective. To investigate whether individuals in the chronic phase after mild stroke show balance and gait limitations, elevated fall risk, reduced balance confidence, and physical activity...

journal article 2023

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Magnitude and variability of individual elbow load in repetitive baseball pitching

van Trigt, B. (author), van Hogerwou, Thomas (author), Leenen, A.J.R. (author), Hoozemans, Marco J.M. (author), van der Helm, F.C.T. (author), Veeger, H.E.J. (author)

In baseball pitchers the elbow is exposed to high and repetitive loads (i.e. external valgus torque), caused by pitching a high number of balls in a practice session or game. This can result in overuse injuries like the ulnar collateral ligament (UCL) injury. To understand injury mechanisms, the effect of repetitive pitching on the elbow load...

journal article 2023

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The relevance of reducing Veress needle overshooting

Horeman, T. (author), Postema, R.R. (author), Fischer, T. (author), Calleja-Agius, J. (author), Camenzuli, C. (author), Alvino, L. (author), Hardon, S.F. (author), Bonjer, H. J. (author)

Safe insertion of the Veress needle during laparoscopy relies on the surgeons’ technical skills in order to stop needle insertion just in time to prevent overshooting in the underlying organs. To reduce this risk, a wide variety of Veress needle systems were developed with safety mechanisms that limit the insertion speed, insertion depth or...

journal article 2023

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Examining the role of intrinsic and reflexive contributions to ankle joint hyper-resistance treated with botulinum toxin-A

van’t Veld, Ronald C. (author), Flux, Eline (author), van Oorschot, Wieneke (author), Schouten, A.C. (author), van der Krogt, Marjolein M. (author), van der Kooij, H. (author), Vos-van der Hulst, Marije (author), Keijsers, Noël L.W. (author), van Asseldonk, Edwin H.F. (author)

Background: Spasticity, i.e. stretch hyperreflexia, increases joint resistance similar to symptoms like hypertonia and contractures. Botulinum neurotoxin-A (BoNT-A) injections are a widely used intervention to reduce spasticity. BoNT-A effects on spasticity are poorly understood, because clinical measures, e.g. modified Ashworth scale (MAS),...

journal article 2023

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EASIER: A new model for online learning of minimally invasive surgery skills

Oropesa, Ignacio (author), Sánchez-Peralta, Luisa F. (author), Chmarra, M.K. (author), Berner-Juhos, Krisztina (author), Tiu, Calin (author), Mettouris, Christos (author), Blas Pagador, José (author), Post, Joeri (author), Dankelman, J. (author)

Introduction: Technology Enhanced Learning (TEL) can provide the tools to safely master minimally invasive surgery (MIS) skills in patient-free environments and receive immediate objective feedback without the constant presence of an instructor. However, TEL-based systems tend to work isolated from one another, focus on different skills, and...

journal article 2023

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Identifying lipid traces of atherogenic mechanisms in human carotid plaque

Slijkhuis, Nuria (author), Mirzaian, Mina (author), Korteland, Suze Anne (author), Heijs, Bram (author), van Gaalen, Kim (author), Nieuwenhuizen, Ingeborg (author), van der Heiden, Kim (author), Claude, Emmanuelle (author), van Soest, G. (author)

Background and aims: Lipids play an important role in atherosclerotic plaque development and are interesting candidate predictive biomarkers. However, the link between circulating lipids, accumulating lipids in the vessel wall, and plaque destabilization processes in humans remains largely unknown. This study aims to provide new insights into...

journal article 2023

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Developing a Digital Medication Adherence Intervention for and With Patients With Asthma and Low Health Literacy: Protocol for a Participatory Design Approach

Faber, J.S. (author), Poot, Charlotte C. (author), Dekkers, Tessa (author), Romero Herrera, N.A. (author), Chavannes, N.H. (author), Meijer, Eline (author), Visch, V.T. (author)

Background: Current eHealth interventions are poorly adopted by people with low health literacy (LHL) as they often fail to meet their needs, skills, and preferences. A major reason for this poor adoption is the generic, one-size-fits-all approach taken by designers of these interventions, without addressing the needs, skills, and preferences...

journal article 2023

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DAIS: The Delft Database of EEG Recordings of Dutch Articulated and Imagined Speech

Dekker, Bo (author), Schouten, A.C. (author), Scharenborg, O.E. (author)

Silent speech interfaces could enable people who lost the ability to use their voice or gestures to communicate with the external world, e.g., through decoding the person’s brain signals when imagining speech. Only a few and small databases exist that allow for the development and training of brain computer interfaces (BCIs) that can decode...

conference paper 2023

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Surface Electrocardiogram Reconstruction Using Intra-operative Electrograms

Moghaddasi, Hanie (author), Hunyadi, Borbala (author), van der Veen, A.J. (author), de Groot, N.M.S. (author), Hendriks, R.C. (author)

Atrial Fibrillation (AF) is the most sustained arrhythmia in the heart. On the surface electrocardiogram (ECG), AF is characterised by the irregular RR intervals and by fibrillatory waves or the absence of a P wave. Since AF is a progressive disease, timely and correct detection is crucial for AF treatment. Detailed insight into the areas of...

conference paper 2022

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Quantifying Within-Individual Elbow Load Variability in Youth Elite Baseball Pitchers and Its Role in Overuse Injuries

van Trigt, B. (author), Bouman, F.F. (author), Leenen, Antonius J. R. (author), Hoozemans, Marco J.M. (author), van der Helm, F.C.T. (author), Veeger, H.E.J. (author)

Medial elbow overuse injuries are rising in baseball. The external valgus torque magnitude is a possible risk factor for medial elbow injuries. The magnitude on its own cannot explain why one pitcher sustains an injury and another does not. Therefore, the aim of this study is to describe the within-individual external valgus torque variability...

journal article 2022

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Using Wearable Sensors to Estimate Mechanical Power Output in Cyclical Sports Other than Cycling: A Review

De Vette, V.G. (author), Veeger, H.E.J. (author), van Dijk, M.P. (author)

More insight into in-field mechanical power in cyclical sports is useful for coaches, sport scientists, and athletes for various reasons. To estimate in-field mechanical power, the use of wearable sensors can be a convenient solution. However, as many model options and approaches for mechanical power estimation using wearable sensors exist, and...

review 2022

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Fastball pitching performance only slightly decreases after mobility impediment of the pelvis and trunk—Do (catch-up) compensation strategies come into play?

Leenen, A.J.R. (author), van Trigt, B. (author), Hoozemans, M. J.M. (author), Veeger, H.E.J. (author)

Background: Baseball pitching performance can be mechanically explained by the summation of speed principle and the principle of optimal coordination of partial momenta. Impeding optimal energy generation or transfer by or between the pelvis and trunk segments could provide valuable insight into possible compensation or catch-up mechanisms...

journal article 2022

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Augmented reality navigation for minimally invasive craniosynostosis surgery: a phantom study

Thabit, Abdullah (author), Benmahdjoub, Mohamed (author), van Veelen, Marie Lise C. (author), Niessen, W.J. (author), Wolvius, Eppo B. (author), van Walsum, T. (author)

Purpose: In minimally invasive spring-assisted craniectomy, surgeons plan the surgery by manually locating the cranial sutures. However, this approach is prone to error. Augmented reality (AR) could be used to visualize the cranial sutures and assist in the surgery planning. The purpose of our work is to develop an AR-based system to...

journal article 2022

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Feasibility and validity of a single camera CNN driven musculoskeletal model for muscle force estimation during upper extremity strength exercises: Proof-of-concept

Noteboom, L. (author), Hoozemans, Marco J.M. (author), Veeger, H.E.J. (author), van der Helm, F.C.T. (author)

Muscle force analysis can be essential for injury risk estimation and performance enhancement in sports like strength training. However, current methods to record muscle forces including electromyography or marker-based measurements combined with a musculoskeletal model are time-consuming and restrict the athlete's natural movement due to...

journal article 2022

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Classification of Wheelchair Related Shoulder Loading Activities from Wearable Sensor Data: A Machine Learning Approach

de Vries, Wiebe H.K. (author), Amrein, Sabrina (author), Arnet, Ursina (author), Mayrhuber, Laura (author), Ehrmann, Cristina (author), Veeger, H.E.J. (author)

Shoulder problems (pain and pathology) are highly prevalent in manual wheelchair users with spinal cord injury. These problems lead to limitations in activities of daily life (ADL), labor- and leisure participation, and increase the health care costs. Shoulder problems are often associated with the long-term reliance on the upper limbs, and...

journal article 2022

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Electromyography-driven model-based estimation of ankle torque and stiffness during dynamic joint rotations in perturbed and unperturbed conditions

Cop, Christopher P. (author), Schouten, A.C. (author), Koopman, Bart (author), Sartori, Massimo (author)

The simultaneous modulation of joint torque and stiffness enables humans to perform large repertoires of movements, while versatilely adapting to external mechanical demands. Multi-muscle force control is key for joint torque and stiffness modulation. However, the inability to directly measure muscle force in the intact moving human prevents...

journal article 2022