Fabrication and characterization of an Upside-down CNT MEA

Over the last few years the need of new alternatives to traditional disease modelling, drug screening and toxicity tests has boosted the development of a new class of devices called Organ on Chip. These usually consist in a substrate or a well in which cells are cultured with the aim of differentiating them in a particular tissue lineage. With...

Fabrication of a microporous PDMS membrane for an Organ-on-Chip device

Organs on chips are a novel set of devices whose aim is to mimic cellular in-vivo conditions of the human physiology within a microchip. The need of reliable disease models, particularly for the development of pharmaceutical drugs, has drawn increased attention as the current widespread models; static cell cultures and animal tests, have proven...

Assessment of Cytostretch - A Heart-On-Chip device. Experiments on Cardiomyocytes

An organ-on-chip device, called Cytostretch (Philips NV), that is capable of mechanically stimulating cultured cells, is the subject of this study. The device comprises a microthin PolyDiMethylSiloxane membrane that is highly elastic, on which titanium nitride electrodes have been embedded. Its utility is projected in cardiac research to emulate...