Searched for: mods_note_programme_s%3A%22Applied%255C+Sciences%255C+%257C%255C+Nanobiology%22
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van Heuckelum, Joran (author)
<div>Implant-associated infections by antibiotic-resistant biofilm-forming pathogenic bacteria such as <i>Staphylococcus aureus</i> have become a growing concern as they are difficult to treat and lead to implant revision surgery. Implant coatings consisting of superparamagnetic iron oxide nanoparticles may prevent the attachment to and...
master thesis 2023
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van den Biggelaar, Lars (author)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a respiratory virus capable of infecting humans and causing mild to severe complications during and after infection, which collectively comprise coronavirus disease 2019 (COVID-19). After an initial local epidemic in late 2019, the virus quickly spread on a global scale and was...
bachelor thesis 2023
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Beets, Josine (author)
Incorporating living cells into a non-living matrix is one of the many possible steps that can be undertaken to stop climate change. Especially, photosynthetic organisms have a promising future in material design as they can capture atmospheric carbon dioxide and ’ breathe’ oxygen. This research dives into unravelling the properties of a...
master thesis 2023
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Holtgrefe, Tim (author)
Microtubules are long cylindrical polymers, assembled from tubulin proteins. Microtubule ends can be visualized using fluorescence and confocal microscopy. This allows for the study of microtubule dynamics. However, the manual annotation of microtubules is laborious, which is why automated tracking methods are used. In this project we have...
bachelor thesis 2023
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Jansen, Flip (author)
Gas vesicles, micrometer-scale protein structures that function as bacterial buoyancy providers, encapsulate gas in a highly optimized manner. While their atomic structure has been elucidated through single-particle analysis of cryo-EM images, certain structural and functional details remain uncertain. Its biogenesis - the formation and growth...
master thesis 2023
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Kruit, Vincent (author)
master thesis 2023
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Hellebrekers, Vincent (author)
The thesis is composed of two parts. The first part is the scientific article<br/>that describes the main findings for our objective to align cerebral DSA series.<br/>The second part of the thesis includes more extensive information regarding<br/>the clinical and technical background of the project. Additionally, it contains<br/>information on...
master thesis 2023
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Kostina, Polina (author)
The study of the electrophysiological properties of neurons has reached a new level thanks to recent techniques that combine knowledge from different fields of science. For a method such as all-optical electrophysiology, the quality of cell segmentation in the image has one of the critical roles since the accuracy of illumination and...
bachelor thesis 2022
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de Ridder, Djim (author)
In animal cells, cell shape is primarily regulated by the actin cortex, a thin filament network connected to the plasma membrane. The architecture of the cortex is considered a key regulator of its function. Visualising the cortex is difficult due to the high density of numerous small-sized proteins involved in its formation. Consequently, the...
master thesis 2022
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Kruit, Vincent (author)
bachelor thesis 2021
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van Kooij, Kirsten (author)
Cancer remains responsible for a large part of deaths worldwide. At present most treatments for cancer still give rise to unwanted side-effects. In this thesis, a treatment that combines both chemo- and radiotherapy to reduce the side-effects of chemotherapy is reported. Instead of allowing the drug to spread through the whole body and also...
master thesis 2021
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Jansen, Flip (author)
Structural and functional characterization of membrane proteins (MPs) requires extraction from the native lipid bilayer, which generally necessitates the formation of water-soluble MPs structures or complexes suitable for biochemical assays. These structures are often detergent micelles that form protein-detergent complexes (PDCs), due to...
bachelor thesis 2020
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GONZALEZ LINARES, Rodrigo (author)
CRISPR-Cas effectors (e.g. Cas9) have been widely used to perform genetic knock-outs. Performing knock-ins however, remains challenging due to the inefficiency of the endogenous pathway cells use to integrate a donor genetic cargo into its genome (homology directed repair) when compared to other repair pathways like non-homologous end joining....
master thesis 2020
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van de Grint, Jacinta (author)
Microorganisms can cooperate with each other, meaning that individual cells work together to pursue a common interest. Cooperation can be crucial for microorganisms to survive stressful environmental conditions. In this work, we report on the cooperative behaviour by the yeast S. cerevisiae and the bacterium E. coli, which stimulates survival...
master thesis 2020
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de Jong, Sonny Floyd (author)
Predicting off-target cleavage sites for CRISPR/Cas nucleases on the human genome based on biophysical modelling and high-throughput biochemical profiling.
bachelor thesis 2020
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Verhagen, Mathijs (author)
Cancer metastasis, the spread of cancer to distant organs, is the major cause of cancerrelated mortality. Hence, understanding the mechanisms underlying cancer metastasis is crucial to improve clinical interventions. Despite intensive efforts, the driving mechanisms remain ill-understood due to the difficulties posed by studying the different...
master thesis 2019
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Hengst, Madusha (author)
In eukaryotic cells, the segregation of nuclear information from the cytosol is carried out by the Nuclear Envelope, a double lipid membrane which protects the genes from cytoplasmic mutagens. To establish a connection between the cytoplasm and nucleoplasm, tiny pores named Nuclear Pore Complexes (NPCs) span through such membrane. The biological...
bachelor thesis 2019
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Mattens, Jard (author)
bachelor thesis 2019
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Mulleners, Otto (author)
Congestive heart failure is a common illness affecting 1-2% of the population in developed countries. Due to the recent attempts to replace animal models, as well as the poor predictive value of animal models in heart failure. The development of a new in vivo heart model is critical for the development and testing of new drugs. The HeartCHIP...
bachelor thesis 2017
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