Searched for: mods_originInfo_publisher_s%3A%22Public%255C+Library%255C+of%255C+Science%22
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De Jong, J. (author), Akhtar, W. (author), Badhai, J. (author), Rust, A.G. (author), Rad, R. (author), Hilkens, J. (author), Berns, A. (author), Van Lohuizen, M. (author), Wessels, L.F.A. (author), De Ridder, J. (author)The ability of retroviruses and transposons to insert their genetic material into host DNA makes them widely used tools in molecular biology, cancer research and gene therapy. However, these systems have biases that may strongly affect research outcomes. To address this issue, we generated very large datasets consisting of to unselected...journal article 2014
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Hartanto, D. (author), Kampmann, I.L. (author), Morina, N. (author), Emmelkamp, P.G.M. (author), Neerincx, M.A. (author), Brinkman, W.P. (author)Virtual reality exposure therapy has been proposed as a viable alternative in the treatment of anxiety disorders, including social anxiety disorder. Therapists could benefit from extensive control of anxiety eliciting stimuli during virtual exposure. Two stimuli controls are studied in this study: the social dialogue situation, and the dialogue...journal article 2014
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Forbes, P.A. (author), Dakin, C.J. (author), Geers, A.M. (author), Vlaar, M.P. (author), Happee, R. (author), Siegmund, G.P. (author), Schouten, A.C. (author), Blouin, J.S. (author)Electrical vestibular stimulation is often used to assess vestibulo-motor and postural responses in both clinical and research settings. Stochastic vestibular stimulation (SVS) is a recently established technique with many advantages over its square-wave counterpart; however, the evoked muscle responses remain relatively small. Although the...journal article 2014
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Horeman, T. (author), Meijer, E.J. (author), Harlaar, J.J. (author), Lange, J.F. (author), Van den Dobbelsteen, J.J. (author), Dankelman, J. (author)The tension in a suture is an important factor in the process of wound healing. If there is too much tension in the suture, the blood flow is restricted and necrosis can occur. If the tension is too low, the incision opens up and cannot heal properly. The purpose of this paper is to describe the design and evaluation of the Stitch Force (SF)...journal article 2013
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Prado Vega, R. (author), Van Leeuwen, P.M. (author), Rendon Velez, E. (author), Lemij, H.G. (author), De Winter, J.C. (author)The objective of this study was to evaluate differences in driving performance, visual detection performance, and eye-scanning behavior between glaucoma patients and control participants without glaucoma. Glaucoma patients (n = 23) and control participants (n = 12) completed four 5-min driving sessions in a simulator. The participants were...journal article 2013
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Honarmand Ebrahimi, K. (author), Dienemann, C. (author), Hoefgens, S. (author), Than, M.E. (author), Hagedoorn, P.L. (author), Hagen, W.R. (author)The ubiquitous 24-meric iron-storage protein ferritin and multicopper oxidases such as ceruloplasmin or hephaestin catalyze oxidation of Fe(II) to Fe(III), using molecular oxygen as oxidant. The ferroxidase activity of these proteins is essential for cellular iron homeostasis. It has been reported that the amyloid precursor protein (APP) also...journal article 2013
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De Winter, J.C.F. (author), Happee, R. (author)Concerns exist within the medical and psychological sciences that many published research findings are not replicable. Guidelines accordingly recommend that the file drawer effect should be eliminated and that statistical significance should not be a criterion in the decision to submit and publish scientific results. By means of a simulation...journal article 2013
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Van Loenhout, M.T. (author), De Vlaminck, I. (author), Flebus, B. (author), Den Blanken, J.F. (author), Zweifel, L.P. (author), Hooning, K.M. (author), Kerssemakers, J.W. (author), Dekker, C. (author)The functional state of the genome is determined by its interactions with proteins that bind, modify, and move along the DNA. To determine the positions and binding strength of proteins localized on DNA we have developed a combined magnetic and optical tweezers apparatus that allows for both sensitive and label-free detection. A DNA loop, that...journal article 2013
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Doerr, C. (author), Blenn, N. (author), Van Mieghem, P. (author)The infection times of individuals in online information spread such as the inter-arrival time of Twitter messages or the propagation time of news stories on a social media site can be explained through a convolution of lognormally distributed observation and reaction times of the individual participants. Experimental measurements support the...journal article 2013
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Klijn, C. (author), Koudijs, M.J. (author), Kool, J. (author), Ten Hoeve, J. (author), Boer, M. (author), De Moes, J. (author), Akhtar, W. (author), Van Miltenburg, M. (author), Vendel-Zwaagstra, A. (author), Reinders, M.J.T. (author), Adams, D.J. (author), Van Lohuizen, M. (author), Hilkens, J. (author), Wessels, L.F.A. (author), Jonkers, J. (author)Cancer develops through a multistep process in which normal cells progress to malignant tumors via the evolution of their genomes as a result of the acquisition of mutations in cancer driver genes. The number, identity and mode of action of cancer driver genes, and how they contribute to tumor evolution is largely unknown. This study deployed...journal article 2013
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Oliver, R.C. (author), Lipfert, J. (author), Fox, D.A. (author), Lo, R.H. (author), Doniach, S. (author), Columbus, L. (author)Micelle-forming detergents provide an amphipathic environment that can mimic lipid bilayers and are important tools for solubilizing membrane proteins for functional and structural investigations in vitro. However, the formation of a soluble protein-detergent complex (PDC) currently relies on empirical screening of detergents, and a stable and...journal article 2013
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Mugge, W. (author), Van der Helm, F.C.T. (author), Schouten, A.C. (author)Complex regional pain syndrome (CRPS) is characterized by pain and disturbed blood flow, temperature regulation and motor control. Approximately 25% of cases develop fixed dystonia. The origin of this movement disorder is poorly understood, although recent insights suggest involvement of disturbed force feedback. Assessment of sensorimotor...journal article 2013
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Hagen, W.R. (author)EPR spectroscopy employs a resonator operating at a single microwave frequency and phase-sensitive detection using modulation of the magnetic field. The X-band spectrometer is the general standard with a frequency in the 9–10 GHz range. Most (bio)molecular EPR spectra are determined by a combination of the frequency-dependent electronic Zeeman...journal article 2013
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Liv, N. (author), Zonnevylle, A.C. (author), Narvaez, A.C. (author), Effting, A.P.J. (author), Voorneveld, P.W. (author), Lucas, M.S. (author), Hardwick, J.C. (author), Wepf, R.A. (author), Kruit, P. (author), Hoogenboom, J.P. (author)Correlative light and electron microscopy (CLEM) is a unique method for investigating biological structure-function relations. With CLEM protein distributions visualized in fluorescence can be mapped onto the cellular ultrastructure measured with electron microscopy. Widespread application of correlative microscopy is hampered by elaborate...journal article 2013
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Van Vugt-Lussenburg, B.M.A. (author), Van der Weel, L. (author), Hagen, W.R. (author), Hagedoorn, P.L. (author)Background: The highly homologous [4Fe-4S] containing fumarases FumA and FumB, sharing 90% amino acid sequence identity, from Escherichia coli are differentially regulated, which suggests a difference in their physiological function. The ratio of FumB over FumA expression levels increases by one to two orders of magnitude upon change from...journal article 2013
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De Ridder, J. (author), Abeel, T. (author), Michaut, M. (author), Satagopam, V.P. (author), Gehlenborg, N. (author)You finished your PhD, have been a postdoc for a while, and you start wondering, "What's next?" Suppose you come to the conclusion that you want to stay in academia, and move up the ladder to become a principal investigator (PI). How does one reach this goal given that academia is one of the most competitive environments out there? And suppose...journal article 2013
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Bult, W. (author), Kroeze, S.G.C. (author), Elschot, M. (author), Seevinck, P.R. (author), Beekman, F.J. (author), De Jong, H.W.A.M. (author), Uges, D.R.A. (author), Kosterink, J.G.W. (author), Luijten, P.R. (author), Hennink, W.E. (author)The increasing incidence of small renal tumors in an aging population with comorbidities has stimulated the development of minimally invasive treatments. This study aimed to assess the efficacy and demonstrate feasibility of multimodality imaging of intratumoral administration of holmium-166 microspheres (166HoAcAcMS). This new technique locally...journal article 2013
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Grimes, M.L. (author), Lee, W.J. (author), Van der Maaten, L. (author), Shannon, P. (author)The interpretation of biological data sets is essential for generating hypotheses that guide research, yet modern methods of global analysis challenge our ability to discern meaningful patterns and then convey results in a way that can be easily appreciated. Proteomic data is especially challenging because mass spectrometry detectors often miss...journal article 2013
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Khmelinskii, A. (author), Groen, H.C. (author), De Jong, M. (author), Lelieveldt, B.P.F. (author)Whole-body SPECT small animal imaging is used to study cancer, and plays an important role in the development of new drugs. Comparing and exploring whole-body datasets can be a difficult and time-consuming task due to the inherent heterogeneity of the data (high volume/throughput, multi-modality, postural and positioning variability). The goal...journal article 2012
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Van den Berg, B.A. (author), Reinders, M.J.T. (author), Hulsman, M. (author), Wu, L. (author), Pel, H.J. (author), Roubos, J.A. (author), De Ridder, D. (author)Protein sequence features are explored in relation to the production of over-expressed extracellular proteins by fungi. Knowledge on features influencing protein production and secretion could be employed to improve enzyme production levels in industrial bioprocesses via protein engineering. A large set, over 600 homologous and nearly 2,000...journal article 2012
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