Co-Culture of Precision-Cut Liver Slices and Liver-Derived Mesenchymal Stromal Cells: An ex vivo model for mesenchymal stromal cell administration during hypothermic oxygenated machine perfusion of the liver

Due to the limited availability of suitable livers for transplantation and the increasing use of suboptimal donor livers, which are more prone to ischemia-reperfusion injury (IRI), there is an urgent need for novel graft-ameliorating therapies. The promising capacities of (liver-derived) mesenchymal stromal cells ((L-)MSC) in mitigating IRI and...