Integration of electro-chemical FET-based sensors in silicon- and polymer-based organs-on-chip

Currently, preclinical drug testing and disease modelling are based on static cell cultures and animal models that often fail at predicting the human pathophysiology. Alternatively, Organ-on-Chips (OoCs), dynamic microphysiological platforms, can be employed to recapitulate organ functions and mimic the cell's microphysiological environment....

Dual-Gate Fet-Based Charge Sensor Enhanced by In-Situ Electrode Decoration in a MEMS Organs-On-Chip Platform

Continuous monitoring of tissue microphysiology is a key enabling feature of the organ-on-chip (OoC) approach for drug screening and disease modeling. Sensing charged species in OoC tissue microenvironments is thereby essential. However, the inherently small (i.e., cm) size of OoC devices poses the challenging requirement to integrate...