document

Automated Detection and Segmentation of Large Lesions in CT Colonography

Grigorescu, S.E. (author), Nevo, S.T. (author), Liedenbaum, M.H. (author), Truyen, R. (author), Stoker, J. (author), Van Vliet, L.J. (author), Vos, F.M. (author)

Computerized tomographic colonography is a minimally invasive technique for the detection of colorectal polyps and carcinoma. Computer-aided diagnosis (CAD) schemes are designed to help radiologists locating colorectal lesions in an efficient and accurate manner. Large lesions are often initially detected as multiple small objects, due to which...

journal article 2010

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Radioactive Holmium Acetylacetonate Microspheres for Interstitial Microbrachytherapy: An In Vitro and In Vivo Stability Study

Bult, W. (author), De Leeuw, H. (author), Steinebach, O.M. (author), Van der Bom, M.J. (author), Wolterbeek, H.T. (author), Heeren, R.M.A. (author), Bakker, C.J.G. (author), Van het Schip, A.D. (author), Hennink, W.E. (author), Nijsen, F.W. (author)

Purpose The clinical application of holmium acetylacetonate microspheres (HoAcAcMS) for the intratumoral radionuclide treatment of solid malignancies requires a thorough understanding of their stability. Therefore, an in vitro and an in vivo stability study with HoAcAcMS was conducted. Methods HoAcAcMS, before and after neutron irradiation, were...

journal article 2011

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Pigmented paraaxillary located “complex” basal cell carcinoma imitating clinically irritated melanocytic lesion -succesfull surgical approach in Bulgarian patient

Voicu, Cristiana (author), Mihai, Mara Madalina (author), Lupu, Mihai (author), Patterson, James W. (author), Koleva, Nely (author), Wollina, Uwe (author), Lotti, T. (author), Lotti, Jacopo (author), França, Katlein (author), Batashki, Atanas (author), Gianfaldoni, Serena (author), Bakardzhiev, Ilko (author), Mangarov, Hristo (author), Tchernev, Georgi (author)

Background: Basal cell carcinoma (BCC) is the most frequently encountered neoplasm worldwide. While nodular BCC is the most frequent clinical subtype, other forms of BCC, such as superficial, cystic, morpheiform, infiltrative, and pigmented may also be encountered. CASE PRESENTATION: We present the case of a 67-year-old male with a relatively...

journal article 2017

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Dermatosurgery rounds - the island SKIN infraorbital flap

Tchernev, Georgi (author), Gianfaldoni, Serena (author), Wollina, Uwe (author), Lotti, T. (author), Lotti, Jacopo (author), França, Katlein (author), Batashki, Atanas (author), Maximov, Georgi Konstantinov (author)

The main objective in dermatologic surgery is complete excision of the tumour while achieving the best possible functional and cosmetic outcome. Also we must take into account age, sex, and tumour size and site. We should also consider the patient's expectations, the preservation of the different cosmetic units, and the final cosmetic outcome...

journal article 2017

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Fibroepithelioma of Pinkus (FeP) located in the left lower quadrant of the abdomen - Case Report and review of the literature

Mihai, Mara Madalina (author), Voicu, Cristiana (author), Lupu, Mihai (author), Koleva, Nely (author), Patterson, James W. (author), Lotti, T. (author), Lotti, Jacopo (author), França, Katlein (author), Batashki, Atanas (author), Bakardzhiev, Ilko (author), Wollina, Uwe (author), Tchernev, Georgi (author)

Background: Fibroepithelioma of Pinkus (FeP) is an uncommon and controversial skin lesion, sharing features of both basal cell carcinoma (BCC) and trichoepithelioma. In this article, we present a case of FeP and synthesise current concepts on the etiopathogenesis, diagnosis and treatment of this uncommon tumour. Case Report: We report the...

review 2017

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Lichen simplex chronicus as an essential part of the dermatologic masquerade

Voicu, Cristiana (author), Tebeica, Tiberiu (author), Zanardelli, Matteo (author), Mangarov, Hristo (author), Lotti, T. (author), Wollina, Uwe (author), Lotti, Jacopo (author), França, Katlein (author), Batashki, Atanas (author), Tchernev, Georgi (author)

A 48 years old female patient had been suffering from the lesions presented for four years. They have started as small, pruritic patches which had been mechanically irritated and grew up in time. The patient had no associated comorbidities or allergies, and she was not under any medication. On physical examination, she presented one...

journal article 2017

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Classification of malignant and benign liver tumors using a radiomics approach

Starmans, Martijn P.A. (author), Miclea, Razvan L. (author), van der Voort, S.R. (author), Niessen, W.J. (author), Thomeer, Maarten G. (author), Klein, S. (author)

Correct diagnosis of the liver tumor phenotype is crucial for treatment planning, especially the distinction between malignant and benign lesions. Clinical practice includes manual scoring of the tumors on Magnetic Resonance (MR) images by a radiologist. As this is challenging and subjective, it is often followed by a biopsy. In this study,...

conference paper 2018

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Genetic factors associated with a poor outcome in head and neck cancer patients receiving definitive chemoradiotherapy

Vossen, David M. (author), Verhagen, Caroline V.M. (author), van der Heijden, Martijn (author), Essers, Paul B.M. (author), Bartelink, Harry (author), Verheij, Marcel (author), Wessels, L.F.A. (author), van den Brekel, Michiel W.M. (author), Vens, Conchita (author)

About half of advanced stage head and neck squamous cell carcinoma (HNSCC) patients can be cured by chemoradiotherapy. Patient outcome may be partially determined by the genetic alterations in HNSCC, rendering these alterations promising candidate prognostic factors and/or therapeutic targets. However, their relevance in patient outcome...

journal article 2019

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Response of metastatic mouse invasive lobular carcinoma to mTOR inhibition is partly mediated by the adaptive immune system

Klarenbeek, Sjoerd (author), Doornebal, Chris W. (author), Kas, Sjors M. (author), Bonzanni, Nicola (author), Bhin, Jinhyuk (author), Braumuller, Tanya M. (author), van der Heijden, Ingrid (author), de Bruijn, Roebi (author), Wessels, L.F.A. (author)

Effective treatment of invasive lobular carcinoma (ILC) of the breast is hampered by late detection, invasive growth, distant metastasis, and poor response to chemotherapy. Phosphoinositide 3-kinase (PI3K) signaling, one of the major druggable oncogenic signaling networks, is frequently activated in ILC. We investigated treatment response and...

journal article 2020

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Automated classification of significant prostate cancer on MRI: A systematic review on the performance of machine learning applications

Castillo, Jose M.T. (author), Arif, Muhammad (author), Niessen, W.J. (author), Schoots, Ivo G. (author), Veenland, J.F. (author)

Significant prostate carcinoma (sPCa) classification based on MRI using radiomics or deep learning approaches has gained much interest, due to the potential application in assisting in clinical decision-making. Objective: To systematically review the literature (i) to determine which algorithms are most frequently used for sPCa classification...

journal article 2020

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A multi-center, multi-vendor study to evaluate the generalizability of a radiomics model for classifying prostate cancer: High grade vs. low grade

Castillo, J.M. (author), Starmans, M.P.A. (author), Arif, M. (author), Niessen, W.J. (author), Klein, Stefan (author), Bangma, Chris H. (author), Schoots, Ivo G. (author), Veenland, J.F. (author)

Radiomics applied in MRI has shown promising results in classifying prostate cancer lesions. However, many papers describe single-center studies without external validation. The issues of using radiomics models on unseen data have not yet been sufficiently addressed. The aim of this study is to evaluate the generalizability of radiomics...

journal article 2021

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Optical tissue measurements of invasive carcinoma and ductal carcinoma in situ for surgical guidance

de Boer, Lisanne L. (author), Kho, Esther (author), Van de Vijver, Koen K. (author), Vranken Peeters, Marie Jeanne T.F.D. (author), van Duijnhoven, Frederieke (author), Hendriks, B.H.W. (author), Sterenborg, Henricus J.C.M. (author), Ruers, Theo J.M. (author)

Background: Although the incidence of positive resection margins in breast-conserving surgery has decreased, both incomplete resection and unnecessary large resections still occur. This is especially the case in the surgical treatment of ductal carcinoma in situ (DCIS). Diffuse reflectance spectroscopy (DRS), an optical technology based on...

journal article 2021

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Development and Evaluation of an Integrated Medical Imaging Workstation for Diagnostic and Surgical Planning Support in Pancreatic Cancer

Rasenberg, Diederik (author)

Introduction <br/>Pancreatic cancer is currently the fourth leading cause of cancer death in the United States and has only a 5-year survival rate of 10%. Pancreatoduodenectomy is the cornerstone of curative treatment for patients diagnosed with pancreatic head cancer. Only 20% of the patients are candidate for surgery since many patients...

master thesis 2021

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Hyperspectral Imaging for Tissue Classification after Advanced Stage Ovarian Cancer Surgery: A Pilot Study

Perez, S.M. (author), van de Berg, N.J. (author), Manni, Francesca (author), Lai, Marco (author), Rijstenberg, Lucia (author), Hendriks, B.H.W. (author), Dankelman, J. (author), Ewing-Graham, Patricia C. (author), Nieuwenhuyzen, G.M. (author), Van Beekhuizen, Heleen J. (author)

The most important prognostic factor for the survival of advanced-stage epithelial ovarian cancer (EOC) is the completeness of cytoreductive surgery (CRS). Therefore, an intraoperative technique to detect microscopic tumors would be of great value. The aim of this pilot study is to assess the feasibility of near-infrared hyperspectral imaging ...

journal article 2022

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Classification of clinically significant prostate cancer on multi-parametric MRI: A validation study comparing deep learning and radiomics

Castillo, J.M. (author), Arif, M. (author), Starmans, M.P.A. (author), Niessen, W.J. (author), Bangma, C.H. (author), Schoots, Ivo G. (author), Veenland, J.F. (author)

The computer-aided analysis of prostate multiparametric MRI (mpMRI) could improve significant-prostate-cancer (PCa) detection. Various deep-learning-and radiomics-based methods for significant-PCa segmentation or classification have been reported in the literature. To be able to assess the generalizability of the performance of these methods,...

journal article 2022

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Patient-derived breast model repository, a tool for hyperthermia treatment planning and applicator design

Androulakis, Ioannis (author), Sumser, Kemal (author), Machielse, Melanie N.D. (author), Koppert, Linetta (author), Jager, Agnes (author), Nout, Remi (author), Franckena, Martine (author), van Rhoon, G.C. (author), Curto, Sergio (author)

Objective: The addition of hyperthermia in the treatment of intact breast cancer with the aim to improve local response is currently in a research phase. First, optimal hyperthermia devices need to be developed, for which a diverse, anatomically and pathologically accurate set of patient models is necessary. Methods: To investigate the...

journal article 2022

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Thermal ablation of primary liver tumors: Correspondence of the predicted ablation zone with the clinically obtained ablation zone

van Erp, Gonnie (author)

<b>Purpose</b> Manufacturer’s predictions of ablation zone dimensions are the current directives for treatment planning in thermal ablation, while they are mostly based on ex vivo experiments making its reliability questionable. The aim of this study is to determine the correspondence in dimensions, volume, shape and overlap of the manufactures’...

master thesis 2022

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Intraprocedural assessment of ablation margins using computed tomography co-registration in hepatocellular carcinoma treatment with percutaneous ablation: IAMCOMPLETE study

Hendriks, P. (author), van Dijk, Kiki M. (author), Boekestijn, Bas (author), Broersen, Alexander (author), van Duijn-de Vreugd, Jacoba J. (author), Coenraad, Minneke J. (author), Dijkstra, J. (author), de Geus-Oei, L.F. (author), Burgmans, M.C. (author)

Purpose: The primary objective of this study was to determine the feasibility of ablation margin quantification using a standardized scanning protocol during thermal ablation (TA) of hepatocellular carcinoma (HCC), and a rigid registration algorithm. Secondary objectives were to determine the inter- and intra-observer variability of tumor...

journal article 2023

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Patient-Reported Mobility, Physical Activity, and Bicycle Use after Vulvar Carcinoma Surgery

van de Berg, N.J. (author), van Beurden, F.P. (author), Wendel-Vos, G. C. Wanda (author), Duijvestijn, Marjolein (author), van Beekhuizen, Heleen J. (author), Maliepaard, Marianne (author), van Doorn, Helena C. (author)

Patients treated for vulvar carcinoma may experience losses in mobility and physical activity. In this study, we assess the prevalence and severity of mobility problems using patient-reported outcomes of three questionnaires: EQ-5D-5L to estimate QoL and perceived health; SQUASH to estimate habitual physical activity; and a problem-specific...

journal article 2023

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Tumor decellularization reveals proteomic and mechanical characteristics of the extracellular matrix of primary liver cancer

van Tienderen, Gilles S. (author), Conboy, J.P. (author), Muntz, I.A.A. (author), Willemse, Jorke (author), Tieleman, Jantine (author), Monfils, Kathryn (author), Schurink, Ivo J. (author), Demmers, J.A.A. (author), Koenderink, G.H. (author)

Tumor initiation and progression are critically dependent on interaction of cancer cells with their cellular and extracellular microenvironment. Alterations in the composition, integrity, and mechanical properties of the extracellular matrix (ECM) dictate tumor processes including cell proliferation, migration, and invasion. Also in primary...

journal article 2023