Quantitative MRI protocol and decision model for a ‘one stop shop’ early-stage Parkinsonism diagnosis: Study design

Differentiating among early-stage parkinsonisms is a challenge in clinical practice. Quantitative MRI can aid the diagnostic process, but studies with singular MRI techniques have had limited success thus far. Our objective is to develop a multi-modal MRI method for this purpose. In this review we describe existing methods and present a...

Mapping functional brain networks from the structural connectome: Relating the series expansion and eigenmode approaches

Functional brain networks are shaped and constrained by the underlying structural network. However, functional networks are not merely a one-to-one reflection of the structural network. Several theories have been put forward to understand the relationship between structural and functional networks. However, it remains unclear how these...

Long-term Effect of MPH on White Matter Tracts of Adults with ADHD: An Application of Consistent Model Selection followed by TBSS

We focused on analysis of long-term medication influenced white matter tracts based on diffusion-weighted MRI brain images of patients with ADHD disorder. We applied a framework of consistent model selection with Tract-based spatial statistics (TBSS) to give proper and consistent modelling of fiber-crossing in white matter. An orientation atlas...

Application of Sophisticated Models to Conventional Diffusion-Weighted MRI Data

The brain’s white matter mainly consists of (myelinated) axons that connect different parts of the brain. Diffusion-weighted MRI (DW-MRI) is a technique that is particularly suited to image this white matter. The MRI signal in DW-MRI is sensitized to diffusion of water in the microstructure by introducing strong bipolar gradients in the MRI...

Morphological maturation of the mouse brain: An in vivo MRI and histology investigation

With the wide access to studies of selected gene expressions in transgenic animals,mice have become the dominant species as cerebral diseasemodels. Many of these studies are performed on animals of not more than eight weeks, declared as adult animals. Based on the earlier reports that full brain maturation requires at least three months in rats,...

Tract based spatial statistics of the normal appearing white matter in the general elderly population

The role of cerebral white matter in intact brain functioning in older age is increasingly being recognized. Recent magnetic resonance (MR) imaging advances enable to non-invasively quantify structural integrity of normal appearing white matter. Studies into white matter integrity in the general elderly population, aim to gain insight into the...