Statistical integration of heterogeneous omics data: Probabilistic two-way partial least squares (PO2PLS)

The availability of multi-omics data has revolutionized the life sciences by creating avenues for integrated system-level approaches. Data integration links the information across datasets to better understand the underlying biological processes. However, high dimensionality, correlations and heterogeneity pose statistical and computational...

Degradation modeling considering unit-to-unit heterogeneity-A general model and comparative study

The performance of units in the same batch can exhibit considerable heterogeneity due to the variation in the raw materials and fluctuation in the manufacturing process. For products suffering performance degradation in their use, such heterogeneity often results in an increase in the dispersion of the degradation paths of units in a...

Probabilistic partial least squares model: Identifiability, estimation and application

With a rapid increase in volume and complexity of data sets, there is a need for methods that can extract useful information, for example the relationship between two data sets measured for the same persons. The Partial Least Squares (PLS) method can be used for this dimension reduction task. Within life sciences, results across studies are...

Probabilistic record linkage with the Fellegi and Sunter framework: Using probabilistic record linkage to link privacy preserved police and hospital road accident records

Record linkage is the procedure of bringing together information from two or more records that are believed to belong to the same entity. The linking of a pair of records without identifier should be based on attributes both records have in common. The probabilistic framework described by Fellegi and Sunter (1969) can be used for record linkage....

Modelling riverflow in the Volta Basin of West Africa: A data-driven framework

In this thesis, a riverflow modelling framework developed for monthly riverflow prediction in the 400,000 km2 Volta Basin of West Africa is presented. By analysing available catchment rainfall, runoff and potential evapotranspiration series in the basin using methods such as correlation plots, autoregressive (AR) and autoregressive with...