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Janssen, D. (author)The dissertation explores the use of emergency measures, particularly the BresDefender, to prevent or delay levee failure and mitigate the impacts of floods, focusing on the Netherlands' flood protection systems. Levees are vital for protecting low-lying areas, but there's always a risk of failure, leading to significant societal and material...doctoral thesis 2024
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Zhu, Xuezhen (author), Zhang, Minghu (author), Shi, Jinyan (author), Weng, Yiwei (author), Yalçınkaya, Çağlar (author), Šavija, B. (author)High-strength engineered cementitious composites (ECC) typically require higher cement content, which is negative from the sustainability point of view. To alleviate this problem, herein a low-cost and eco-friendly high-strength ECC (with a compressive strength of over 100 MPa) was developed, and diatomite was used to replace a small amount...journal article 2024
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van Dinten, I. (author), Derakhshanfar, Pouria (author), Panichella, A. (author), Zaidman, A.E. (author)Cyber-Physical Systems (CPSs) have gained traction in recent years. A major non-functional quality of CPS is performance since it affects both usability and security. This critical quality attribute depends on the specialized hardware, simulation engines, and environmental factors that characterize the system under analysis. While a large body...journal article 2024
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Iuorio, Luca (author), Wüthrich, D. (author), Teng, Djimin (author), Hooimeijer, F.L. (author)Coastal dikes have been built for millennia to protect inhabited lands from exceptional high tides and storm events. Currently, many European countries are developing specific programs to integrate the construction of new dikes (or the raising of existing ones) into the built environment to face sea level rising. Technical difficulties in...journal article 2024
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Tott-Buswell, Jacques (author), Prendergast, Luke J. (author), Gavin, Kenneth (author)Monopiles are the most common Offshore Wind Turbine (OWT) foundations due to their simplicity in design, fabrication, and installation. However, large new-generation turbines have led to significant changes in monopile dimensions, necessitating extensive finite element analyses and ground investigations to meet design requirements. While Cone...journal article 2024
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Xu, J. (author), Vecstaudza, Jana (author), Wesdorp, Marinus A. (author), Labberté, Margot (author), Salerno, Manuela (author), Kok, Joeri (author), van Rietbergen, Bert (author), van Osch, G.J.V.M. (author), Locs, Janis (author), Brama, Pieter A.J. (author)Osteochondral defect repair with a collagen/collagen-magnesium-hydroxyapatite (Col/Col-Mg-HAp) scaffold has demonstrated good clinical results. However, subchondral bone repair remained suboptimal, potentially leading to damage to the regenerated overlying neocartilage. This study aimed to improve the bone repair potential of this scaffold by...journal article 2024
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Jaroensuk, Juthamas (author), Sutthaphirom, Chalermroj (author), Phonbuppha, Jittima (author), Chinantuya, Wachirawit (author), Kesornpun, Chatchai (author), Akeratchatapan, Nattanon (author), Kittipanukul, Narongyot (author), Phatinuwat, Kamonwan (author), Hollmann, F. (author)Cofactor imbalance obstructs the productivities of metabolically engineered cells. Herein, we employed a minimally perturbing system, xylose reductase and lactose (XR/lactose), to increase the levels of a pool of sugar phosphates which are connected to the biosynthesis of NAD(P)H, FAD, FMN, and ATP in Escherichia coli. The XR/lactose system...journal article 2024
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Yin, Xinjian (author), Gong, Wenzhong (author), Zeng, Yujing (author), Qiu, Hulin (author), Liu, Lan (author), Hollmann, F. (author), Chen, Bishuang (author)The biocatalytic oxidative deamination of β-amino alcohols holds significant practical potential in kinetic resolution and/or deracemization process to access (R)-β-amino alcohols. This study exemplifies a notable instance of acquisition and utilization of this valuable oxidative deamination activity. Initially, the mutation N261M (M0) was...journal article 2024
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Zhu, Wenhan (author), Proksch, S. (author), German, Daniel M. (author), Godfrey, Michael W. (author), Li, Li (author), McIntosh, Shane (author)“App stores” are online software stores where end users may browse, purchase, download, and install software applications. By far, the best known app stores are associated with mobile platforms, such as Google Play for Android and Apple’s App Store for iOS. The ubiquity of smartphones has led to mobile app stores becoming a touchstone...journal article 2024
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van den Broek, M.A. (author), Ortiz Merino, R.A. (author), Bennis, N.X. (author), Wronska, A.K. (author), Else-Hassing, J. (author), Daran-Lapujade, P.A.S. (author), Daran, J.G. (author)The biobased-economy aims to create a circular biotechnology ecosystem to transition from a fossil fuel-based to a sustainable industry based on biomass. For this, new microbial cell-factories are essential. We present the draft genome of the CEN.PK-derived Saccharomyces cerevisiae SpyCas9 expressing strain (IMX2600), that serve as chassis of...journal article 2024
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Ingram, A.A. (author), Oike, K. (author)Astonishing progress has been achieved in unlocking new-to-nature biocatalysis in the past decades. The progress in protein engineering enabled research to efficiently incorporate artificial structural elements into enzyme design. Recent trends include cofactor mimetics, artificial metalloenzymes and non-canonical amino acids. In this...journal article 2024
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Challenges and opportunities for CO2 electroreduction from a process systems engineering perspectiveDal Mas, R. (author), Somoza Tornos, A. (author), Pérez-Fortes, Mar (author), Kortlever, R. (author), Kiss, A.A. (author)Despite the huge efforts devoted to the development of the electrochemical reduction of CO2 (ECO2R) in the past decade, still many challenges are present, hindering further approaches to industrial applications. This paper gives a perspective on these challenges from a Process Systems Engineering (PSE) standpoint, while at the same time...journal article 2024
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Zhu, Sicong (author), Yuan, Y. (author), Peng, Wenjie (author), Wu, Hangbin (author), Yu, Lei (author), Lan, Qing (author)This article presents an integrated educational module for undergraduate traffic engineering at the microscale level. When dealing with a complex transportation system, the education program should cultivate students’ acquisition of both in-depth traffic specialization and breadth of engineering knowledge. For the educational instruction of...journal article 2024
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Miedema, Rene (author), Strydis, C. (author)IntroductionIn-silico simulations are a powerful tool in modern neuroscience for enhancing our understanding of complex brain systems at various physiological levels. To model biologically realistic and detailed systems, an ideal simulation platform must possess: (1) high performance and performance scalability, (2) flexibility, and (3) ease of...journal article 2024
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Cornet, A.J. (author), Homborg, A.M. (author), Ravi Anusuyadevi, P. (author), 't Hoen-Velterop, L. (author), Mol, J.M.C. (author)Despite extensive research, eliminating hexavalent chromium-based inhibitors from aerospace coatings remains challenging due to a lack of understanding of coating degradation during aircraft service. This study addresses the issue by investigating the protective mechanisms and aging processes of chromate-containing coatings on aircraft...journal article 2024
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Krempus, D. (author), Beltrame, F. (author), Majer, M. (author), Colonna, Piero (author), de Servi, C.M. (author), Vos, Roelof (author)This paper presents a preliminary study about a combined-cycle engine based on a turboshaft engine and an organic-Rankine-cycle (ORC) bottoming unit to be used onboard an aircraft with a turboelectric propulsion system. The aim is to analyse whether benefits with respect to mission fuel consumption can be derived by employing such a combined...report 2024
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Berger, Uta (author), Bell, Andrew (author), Barton, C. Michael (author), Chappin, E.J.L. (author), Dreßler, Gunnar (author), Filatova, T. (author), Fronville, Thibault (author), Lee, Allen (author), van Loon, Emiel (author), Lorscheid, Iris (author), Meyer, Matthias (author), Müller, Birgit (author), Piou, Cyril (author), Radchuk, Viktoriia (author), Roxburgh, Nicholas (author), Schüler, Lennart (author), Troost, Christian (author), Wijermans, Nanda (author), Williams, Tim G. (author), Wimmler, Marie Christin (author), Grimm, Volker (author)Despite the increasing use of standards for documenting and testing agent-based models (ABMs) and sharing of open access code, most ABMs are still developed from scratch. This is not only inefficient, but also leads to ad hoc and often inconsistent implementations of the same theories in computational code and delays progress in the...journal article 2024
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Li, Q. (author), Somoza Tornos, A. (author), Grievink, J. (author), Kiss, A.A. (author)Process Intensification (PI) is an effective way to enhance process efficiency and sustainability at affordable costs and efforts, attracting particular interest in the European area, as one of the most important chemical production areas in the world. PI primarily contributes by developing and testing new processing technologies that once...journal article 2024
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Marchiori, S. (author), Scharp, Kevin (author)Recent work on philosophy of technology emphasises the ways in which technology can disrupt our concepts and conceptual schemes. We analyse and challenge existing accounts of conceptual disruption, criticising views according to which conceptual disruption can be understood in terms of uncertainty for conceptual application, as well as views...journal article 2024
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Andersen, Rasmus (author), Napoleone, A. (author), Andersen, Ann Louise (author), Brunoe, Thomas Ditlev (author), Nielsen, Kjeld (author)Pursuing manufacturing competitiveness in the dynamic industrial landscape necessitates implementing changeable and reconfigurable manufacturing systems (RMS) capable of rapid adaptation to varying functionalities and capacities. However, current manufacturing system development methods often overlook product-driven changes during the system...journal article 2024