Engineering a Highly Regioselective Fungal Peroxygenase for the Synthesis of Hydroxy Fatty Acids

The hydroxylation of fatty acids is an appealing reaction in synthetic chemistry, although the lack of selective catalysts hampers its industrial implementation. In this study, we have engineered a highly regioselective fungal peroxygenase for the ω-1 hydroxylation of fatty acids with quenched stepwise over-oxidation. One single mutation near...

A multi-axis robot-based bioprinting system supporting natural cell function preservation and cardiac tissue fabrication

Despite the recent advances in artificial tissue and organ engineering, how to generate large size viable and functional complex organs still remains as a grand challenge for regenerative medicine. Three-dimensional bioprinting has demonstrated its advantages as one of the major methods in fabricating simple tissues, yet it still faces...

Effect of Impact and Bearing Parameters on Bird Strike with Aero-Engine Fan Blades

Bird strikes are one major accident for aircraft engines and can inflict heavy casualties and economic losses. In this study, a smoothed particle hydrodynamics (SPH) mallard model has been used to simulate bird impact to rotary aero-engine fan blades. The simulations were performed using the finite element method (FEM) at LS-DYNA. The...

An Interface Co-modification Strategy for Improving the Efficiency and Stability of CsPbI₃Perovskite Solar Cells

Interface engineering is a simple and effective strategy for improving the photovoltaic performance and stability of perovskite solar cells (PSCs). Herein, an interface co-modification strategy is proposed, using [6,6]-phenyl-C61-butyric acid methyl ester (PCBM) and 2-fluoro-1,4-phenylenediammonium iodide (2FPPD) to modify the electron...

Strength formation mechanism and performance of steel slag self-compacting epoxy resin concrete

A self-compacting steel slag epoxy resin concrete (SERC) was designed with steel slag as aggregate and epoxy resin as binder for rapid repair of road expansion joints and pavement. At the same time, a group of self-compacting basalt epoxy resin concrete (BERC) with basalt as coarse aggregate and limestone as fine aggregate was set up as the...

Dynamic responses of the aero-engine rotor system to bird strike on fan blades at different rotational speeds

To study the effect of a bird striking engine fan on the rotor system, a low-pressure rotor system dynamic model based on a real aero-engine structure was established. Dynamic equations were derived considering the case of the bird strike force which transferred to the rotor system. The bird strike force was obtained from the bird strike...

Tuning electron transfer by crystal facet engineering of BiVO₄ for boosting visible-light driven photocatalytic reduction of bromate

Removal of bromate (BrO₃⁻) has gained increasing attention in drinking water treatment process. Photocatalysis technology is an effective strategy for bromate removal. During the photocatalytic reduction of bromate process, the photo-generated electrons are reductive species toward bromate reduction and photo-generated...

Replacement of the initial steps of ethanol metabolism in Saccharomyces cerevisiae by ATP-independent acetylating acetaldehyde dehydrogenase

In Saccharomyces cerevisiae ethanol dissimilation is initiated by its oxidation and activation to cytosolic acetyl-CoA. The associated consumption of ATP strongly limits yields of biomass and acetyl-CoA-derived products. Here, we explore the implementation of an ATP-independent pathway for acetyl-CoA synthesis from ethanol that, in theory,...