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Boenders, Arne (author)How will we live together? With this graduation project a strategy has been developed to transform vacant heritage into cyclifiers, buildings that have a positive impact on their environment by creating a way of living together in balance with nature, humans, and buildings. Social public functions with a focus on healthy living, as well as a...master thesis 2023
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Páez Watson, T.W. (author), van Loosdrecht, Mark C.M. (author), Wahl, S.A. (author)The understanding of microbial communities and the biological regulation of its members is crucial for implementation of novel technologies using microbial ecology. One poorly understood metabolic principle of microbial communities is resource allocation and biosynthesis. Resource allocation theory in polyphosphate accumulating organisms ...journal article 2023
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Ziliani, Agustina (author), Bovio-Winkler, Patricia (author), Cabezas, Angela (author), Etchebehere, Claudia (author), Garcia, Hector A. (author), López-Vázquez, Carlos M. (author), Brdjanovic, Damir (author), van Loosdrecht, Mark C.M. (author), Rubio-Rincón, Francisco J. (author)Ca. Accumulibacter was the predominant microorganism (relative FISH bio-abundance of 67 ± 5%) in a lab-scale sequential batch reactor that accomplished enhanced biological phosphorus removal (EBPR) while using glucose and acetate as the carbon sources (1:1 COD-based ratio). Both organic compounds were completely anaerobically consumed. The...journal article 2023
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Jánoska, A. (author), Buijs, Joran (author), van Gulik, W.M. (author)In large scale fermentors the cultivated cells are exposed to dynamic changes in the nutrient concentrations due to imperfect mixing. Based on the characterization of these nutrient gradients in space and time, a rational scale down design can be obtained. This study focuses on the combined gradients of dissolved sugar and oxygen...journal article 2023
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Bongaerts, Michiel (author), Kulkarni, Purva (author), Zammit, Alan (author), Bonte, Ramon (author), Kluijtmans, Leo A. J. (author), Blom, Henk J. (author), Engelke, Udo F. H. (author), Tax, D.M.J. (author), Ruijter, George J.G. (author), Reinders, M.J.T. (author)Untargeted metabolomics (UM) is increasingly being deployed as a strategy for screening patients that are suspected of having an inborn error of metabolism (IEM). In this study, we examined the potential of existing outlier detection methods to detect IEM patient profiles. We benchmarked 30 different outlier detection methods when applied to...journal article 2023
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Lao-Martil, David (author), Verhagen, K.J.A. (author), Valdeira Caetano, Ana H. (author), Pardijs, Ilse H. (author), van Riel, Natal A.W. (author), Wahl, S.A. (author)Microbial metabolism is strongly dependent on the environmental conditions. While these can be well controlled under laboratory conditions, large-scale bioreactors are characterized by inhomogeneities and consequently dynamic conditions for the organisms. How Saccharomyces cerevisiae response to frequent perturbations in industrial...journal article 2023
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Jabar, Shajwan (author)Currently there is a high demand for more housing dwellings, a change in housing compositions, mis-match between household profiles and their space and lastly a growing demand in sustainability, circularity and adaptivity. Re-adaptive housing prevents demolition, transformation to non-housing functions, is more sustainable and continuously meet...master thesis 2022
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Karnaszewska, Adrianna (author)Urban foodscapes project addresses issues concerning the food supply chain in London. It aims to combat problems created by current agri-business practice such as long, complex logistical chains, food waste, carbon emissions, wasted water, energy, labour and land scarcity. Foodscape, being both global and local, lies on the intersection of...master thesis 2022
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Duijghuisen, Jin-Ah (author)One of the largest productive and economic chains in the world is the textile area. Not only providing the highest level of employment around the world but also making this one of the most polluting activities (Provin et al., 2020). There is a growing awareness among the Dutch government that something should change. To take responsibility for...master thesis 2022
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Wang, Jiaqi (author)In the past few decades, urbanisation in China has been witnessed with great speed. While this has brought a rocketing economy and improved citizens’ average living standards, it does not come without any expense. Such intensive urban sprawling and industrialization in China has added up a great risk to upcoming climate challenges, especially...master thesis 2022
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te Duits, Noa (author)This thesis explores the possibility of circularity to regenerate the degraded agricultural systems of the Foodvalley region. The Foodvalley is a regional network organization, consisting of eight municipalities situated partly in the province of Utrecht and partly the province of Gelderland. Circularity is used to describe a way in which...master thesis 2022
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van Aalst, A.C.A. (author), de Valk, S.C. (author), van Gulik, W.M. (author), Jansen, Mickel L.A. (author), Pronk, J.T. (author), Mans, R. (author)Product yield on carbohydrate feedstocks is a key performance indicator for industrial ethanol production with the yeast Saccharomyces cerevisiae. This paper reviews pathway engineering strategies for improving ethanol yield on glucose and/or sucrose in anaerobic cultures of this yeast by altering the ratio of ethanol production, yeast growth...journal article 2022
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Dekker, W.J.C. (author), Jürgens, H. (author), Ortiz Merino, R.A. (author), Mooiman, C. (author), van den Berg, Remon (author), Kaljouw, Astrid (author), Mans, R. (author), Pronk, J.T. (author)While thermotolerance is an attractive trait for yeasts used in industrial ethanol production, oxygen requirements of known thermotolerant species are incompatible with process requirements. Analysis of oxygen-sufficient and oxygen-limited chemostat cultures of the facultatively fermentative, thermotolerant species Ogataea parapolymorpha...journal article 2022
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De Martino, P. (author)Port and city authorities all over Europe and beyond are striving with finding solutions able to combine sustainability with economic growth. Several global urgencies in fact, such as climate change, energy transition, the exponential changes in the scale of ports and ships and last but not least the economic and health shock related to the...book chapter 2022
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Wang, Gangqi (author), Heijs, Bram (author), Kostidis, Sarantos (author), Rietjens, Rosalie G.J. (author), Mahfouz, A.M.E.T.A. (author), Chuva de Sousa Lopes, Susana M. (author), van den Berg, Cathelijne W. (author), van den Berg, Bernard M. (author), Rabelink, Ton J. (author)Accumulating evidence demonstrates important roles for metabolism in cell fate determination. However, it is a challenge to assess metabolism at a spatial resolution that acknowledges both heterogeneity and cellular dynamics in its tissue microenvironment. Using a multi-omics platform to study cell-type-specific dynamics in metabolism in...journal article 2022
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Postma, E.D. (author), Couwenberg, Lucas G.F. (author), van Roosmalen, Roderick N. (author), Geelhoed, J. (author), de Groot, P.A. (author), Daran-Lapujade, P.A.S. (author)Saccharomyces cerevisiae, whose evolutionary past includes a whole-genome duplication event, is characterized by a mosaic genome configuration with substantial apparent genetic redundancy. This apparent redundancy raises questions about the evolutionary driving force for genomic fixation of “minor” paralogs and complicates modular and...journal article 2022
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Tsui, T.P.Y. (author), Derumigny, Alexis (author), Peck, David (author), van Timmeren, A. (author), Wandl, Alex (author)In recent years, implementing a circular economy in cities has been considered by policy makers as a potential solution for achieving sustainability. Existing literature on circular cities is mainly focused on two perspectives: urban governance and urban metabolism. Both these perspectives, to some extent, miss an understanding of space. A...journal article 2022
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Postma, E.D. (author), Else-Hassing, J. (author), Mangkusaputra, Venda (author), Geelhoed, J. (author), de la Torre, P. (author), van den Broek, M.A. (author), Mooiman, C. (author), Pabst, Martin (author), Daran, J.G. (author), Daran-Lapujade, P.A.S. (author)The construction of powerful cell factories requires intensive genetic engineering for the addition of new functionalities and the remodeling of native pathways and processes. The present study demonstrates the feasibility of extensive genome reprogramming using modular, specialized de novo-assembled neochromosomes in yeast. The in vivo...journal article 2022
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Amenta, L. (author), van Timmeren, A. (author)In this chapter, the understanding of circularity goes beyond material resource management, deepening the spatial implications of a more circular management and use of wastescapes, investigated at the urban and metropolitan scale. Besides the health (care) related challenges presented by the current outbreak of the COVID-19 pandemic,...book chapter 2022
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Haringa, C. (author), Tang, W. (author), Noorman, H.J. (author)The compartment model (CM) is a well-known approach for computationally affordable, spatially resolved hydrodynamic modeling of unit operations. Recent implementations use flow profiles based on Computational Fluid Dynamics (CFD) simulations, and several authors included microbial kinetics to simulate gradients in bioreactors. However, these...journal article 2022