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Jánoska, A. (author), Verheijen, Jelle J. (author), Tang, W. (author), Lee, Queenie (author), Sikkema, Baukje (author), van Gulik, W.M. (author)In large-scale bioreactors, there is often insufficient mixing and as a consequence, cells experience uneven substrate and oxygen levels that influence product formation. In this study, the influence of dissolved oxygen (DO) gradients on the primary and secondary metabolism of a high producing industrial strain of Penicillium chrysogenum was...journal article 2022
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Olavarria, Karel (author), Almeida Gaspar Carnet, A.E.P. (author), van Renselaar, Joachim (author), Quakkelaar, Caspar (author), Cabrera, Ricardo (author), Gabriel Guedes da Silva, L. (author), Smids, Aron L. (author), Villalobos, Pablo Andres (author), van Loosdrecht, Mark C.M. (author), Wahl, S.A. (author)Oxygen supply implies higher production cost and reduction of maximum theoretical yields. Thus, generation of fermentation products is more cost-effective. Aiming to find a key piece for the production of (poly)-3-hydroxybutyrate (PHB) as a fermentation product, here we characterize an acetoacetyl-CoA reductase, isolated from a Candidatus...journal article 2020
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Ling, Chen (author), Qiao, Guan Qing (author), Shuai, Bo Wen (author), Olavarria, Karel (author), Yin, Jin (author), Xiang, Rui Juan (author), Song, Kun Nan (author), Shen, Yun Hao (author), Guo, Yingying (author), Chen, G. (author)Halomonas bluephagenesis has been developed as a platform strain for the next generation industrial biotechnology (NGIB) with advantages of resistances to microbial contamination and high cell density growth (HCD), especially for production of polyhydroxyalkanoates (PHA) including poly(3-hydroxybutyrate) (PHB), poly(3-hydroxybutyrate-co-4...journal article 2018
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- Weusthuis, R.A. (author), Visser, W. (author), Pronk, J.T. (author), Scheffers, W.A. (author), Van Dijken, J.P. (author) journal article 1994