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Graauw, Mitchel (author)The dose computation algorithm, or dose engine, is one of the fundamental parts of radiotherapy treatment planning. These algorithms predict how the dose will be distributed inside the patient.<br/>Current dose engines are mainly based on either Monte Carlo simulations (MC) or pencil beam algorithms (PBA). MC being very precise, but relatively...master thesis 2024
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Oud, Michelle (author), Breedveld, Sebastiaan (author), Rojo-Santiago, Jesús (author), Giżyńska, Marta Krystyna (author), Kroesen, Michiel (author), Habraken, S.J.M. (author), Perko, Z. (author), Heijmen, Ben (author), Hoogeman, M.S. (author)Objective. In head-and-neck cancer intensity modulated proton therapy, adaptive radiotherapy is currently restricted to offline re-planning, mitigating the effect of slow changes in patient anatomies. Daily online adaptations can potentially improve dosimetry. Here, a new, fully automated online re-optimization strategy is presented. In a...journal article 2024
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Kuitems, Iris (author)This thesis outlines the project conducted at HollandPTC for the Master Biomedical Engineering, track Medical Physics, at Delft University of Technology. <br/><br/>Metal implants create dosimetric uncertainties in treatment planning and delivery for proton therapy. The purpose of this thesis was to determine the most suitable treatment planning...master thesis 2023
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Knol, Michèle (author)During pre-clinical research on proton therapy, validating the dosimetry is important for accurate and representable results. To ensure that research outcomes can eventually be implemented in clinical practices, it is equally as important to also take biological effects into account. The aim of this thesis was, therefore, to dosimetrically and...master thesis 2023
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Kruithof, Odin (author)With FLASH proton radiotherapy, healthy tissue is spared more compared to conventional proton therapy. The FLASH effect is present at high fractional doses of more than 8 Gy, at ultra-high mean dose rates of more than 40 Gy per second and at dose delivery times of less than 200 milliseconds. However, particle accelerator intrinsic uncertainties...master thesis 2023
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van den Broek, Ruben (author)Introduction Holland PTC (Delft, The Netherlands) is an independent outpatient clinic where ten different types of cancer are treated with Pencil Beam Scanning (PBS). Some of these cancer types are situated in the thoracic region and therefore exposed to breathing motion. The interplay between the dynamic pencil beam delivered in PBS and the...master thesis 2023
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van Zon, Manon (author)Intensity modulated proton therapy is an advanced radiotherapy technique that is used to treat cancer patients. In order to successfully treat a patient, sufficient dose to the tumor is required. However, during the fractionated treatment, multiple errors can cause a difference between the planned and actual dose delivery. To ensure adequate...master thesis 2023
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Goudriaan, Sven (author)Proton irradiation therapy is a powerful form of cancer treatment, promising better dose conformity as compared to conventional radiotherapy. Due to the complex scattering properties of protons, the optimization process that is needed to accurately target the cancer cells whilst causing minimal damage to<br/>the surrounding healthy tissue and...bachelor thesis 2023
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Huele, Iris (author)Purpose Deep inspiration breath hold (DIBH) in photon therapy as well as proton therapy (in free breathing) has been suggested to reduce cardiopulmonary and integral dose without compromising target coverage. The goal is to investigate the dosimetric impact on proton treatment plans of set-up variation and daily anatomy visualized on CBCT prior...master thesis 2023
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Rojo-Santiago, Jesús (author), Korevaar, Erik (author), Perko, Z. (author), Both, Stefan (author), Habraken, S.J.M. (author), Hoogeman, M.S. (author)Background and purpose: In the Netherlands, head-and-neck cancer (HNC) patients are referred for proton therapy (PT) through model-based selection (MBS). However, treatment errors may compromise adequate CTV dose. Our aims are: (i) to derive probabilistic plan evaluation metrics on the CTV consistent with clinical metrics; (ii) to evaluate...journal article 2023
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Rojo-Santiago, Jesús (author), Habraken, S.J.M. (author), Romero, Alejandra Méndez (author), Lathouwers, D. (author), Wang, Yibing (author), Perko, Z. (author), Hoogeman, M.S. (author)Objective. The Dutch proton robustness evaluation protocol prescribes the dose of the clinical target volume (CTV) to the voxel-wise minimum (VWmin) dose of 28 scenarios. This results in a consistent but conservative near-minimum CTV dose (D98%,CTV). In this study, we analyzed (i) the correlation between VWmin/voxel-wise maximum (VWmax)...journal article 2023
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Penner, Crystal (author), Usherovich, Samuel (author), Niedermeier, Jana (author), Belanger-Champagne, Camille (author), Trinczek, Michael (author), Paulssen, E. (author), Hoehr, Cornelia (author)In proton therapy, the dose from secondary neutrons to the patient can contribute to side effects and the creation of secondary cancer. A simple and fast detection system to distinguish between dose from protons and neutrons both in pretreatment verification as well as potentially in vivo monitoring is needed to minimize dose from secondary...journal article 2023
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Niedermeier, Jana (author), Penner, Crystal (author), Usherovich, Samuel (author), Bélanger-Champagne, Camille (author), Paulssen, E. (author), Hoehr, Cornelia (author)In recent years, proton therapy has gained importance as a cancer treatment modality due to its conformality with the tumor and the sparing of healthy tissue. However, in the interaction of the protons with the beam line elements and patient tissues, potentially harmful secondary neutrons are always generated. To ensure that this neutron dose...journal article 2023
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Akolawala, Q. (author), Keuning, F.E. (author), Rovituso, M. (author), van Burik, Wouter (author), van der Wal, E.M. (author), Versteeg, Henri H. (author), Rondon, Araci M.R. (author), Accardo, A. (author)Glioblastoma (GBM) is a devastating cancer of the brain with an extremely poor prognosis. While X-ray radiotherapy and chemotherapy remain the current standard, proton beam therapy is an appealing alternative as protons can damage cancer cells while sparing the surrounding healthy tissue. However, the effects of protons on in vitro GBM models...journal article 2023
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Maasland, Anouk (author)The aim of this thesis is to study the dosimetric feasibility of FLASH proton therapy for early-stage breast cancer patients. The biological effect of FLASH is seen under ultra-high dose-rates conditions and is beneficial in the damage to healthy tissue. The FLASH effect could enable the clinical feasibility of definitive radiotherapy for low...master thesis 2022
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van Oosten, Eva (author)With almost 900.000 new patients per year suffering from head and neck squamous cell carcinomas (HNSCC), who after radiotherapy treatments experience severe side effects, the focus is drawn to proton therapy. Proton therapy results to less side effects since healthy tissues surrounding the tumour receive less radiation dose. This results from...master thesis 2022
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de Groot, Chiel (author)This thesis investigates the tissue sparing effect of FLASH (>40 Gy/s) radiation, as opposed to CONV (conventional, dose rates typically between 0.010.1 Gy/s) radiation. We irradiated zebrafish embryos (4 days past fertilisation) with 116 MeV protons. The aim was (1) to measure the effect, and (2) if the effect were significant, see whether...master thesis 2022
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Negenman, Eva (author)Purpose: Proton therapy has been proposed as an alternative to conventional photon therapy for the treatment of locally advanced cervical cancer (LACC) since these patients experience toxicities. Proton therapy may allow for significant sparing of the organs at risk, reducing the incidence of treatment-related morbidities. The aim of this study...master thesis 2022
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Gajadhar, Vivek (author)Dose calculations in proton therapy need to be computed as fast as possible for successful cancer treatment planning and execution. The dose calculation algorithms that provide enough accuracy for treatment planning, takes too much time to utilise; therefore there is a need for faster alternatives. One of the alternatives is using a...bachelor thesis 2022
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Geerts, Nathan (author)In this report, a transformer based deep learning proton dose calculation algorithm called Dose Transformer Algorithm (DoTA) is described. This model learns to predict proton dose distributions by being trained with Monte Carlo generated data. Monte Carlo is the golden standard of proton dose calculation because it is very accurate, but it has...bachelor thesis 2022