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Di Giacomo, S. (author), Ronchi, M. (author), Borghi, G. (author), Schaart, D.R. (author), Carminati, M. (author), Fiorini, C. (author)Embedding signal processing in the front-end of radiation detectors represents an approach to cope with the growing complexity of nuclear imaging scanners with increasing field of view (i.e., higher number of channels). Machine learning (ML) offers a good compromise between intrinsic image reconstruction performance and computational power....journal article 2024
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den Hertog, Hanna (author)<i><b>Background </b></i>Dynamic SPECT scanning provides a non-invasive way to image the time-dependent distribution of radio-labelled tracers inside living tissue. Beside human medicine, dynamic SPECT also finds its applications in pre-clinical research on small animals. In pre-clinical research, multi-pinhole collimators are used to enable...bachelor thesis 2023
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van Dijk, Bruce (author), Hooning van Duyvenbode, J. Fred F. (author), de Vor, Lisanne (author), Nurmohamed, F. Ruben H.A. (author), Lam, Marnix G.E.H. (author), Poot, Alex J. (author), Ramakers, R.M. (author), Koustoulidou, Sofia (author), Beekman, F.J. (author), Weinans, Harrie (author)Implant infections caused by Staphylococcus aureus are difficult to treat due to biofilm formation, which complicates surgical and antibiotic treatment. We introduce an alternative approach using monoclonal antibodies (mAbs) targeting S. aureus and provide evidence of the specificity and biodistribution of S.-aureus-targeting antibodies in a...journal article 2023
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Nguyen, M.P. (author), Arif, M. (author), Oostenrijk, Bart (author), Goorden, M.C. (author), Beekman, F.J. (author)Microscopic nuclear imaging down to spatial resolutions of a few hundred microns can already be achieved using low-energy gamma emitters (e.g. <sup>125</sup>I, ∼30 keV) and a basic single micro-pinhole gamma camera. This has been applied to in vivo mouse thyroid imaging, for example. For clinically used radionuclides such as <sup>99m</sup>Tc,...journal article 2023
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de Hartog, André (author)In this research the effectiveness of analytical neural networks compared to the maximum likelihood method on the prediction of spatial and DOI positioning of a Gamma detector with a NaI(Tl) scintillator of size 590mm x 470mm x 40mm (x,y,z), with a glass lightguide of size 620mm x 500mm x 4mm and a PMT area of 620mm x 500mm x 40mm with 2-inch...bachelor thesis 2022
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Liu, H. (author), de Kruijff, R.M. (author), Laan, A.C. (author), Beekman, F.J. (author), van den Heuvel, E.J. (author), Ramakers, R.M. (author), Eelkema, R. (author), Denkova, A.G. (author)A variety of polymer micelles are designed for the delivery of chemotherapeutic drugs to tumors. Although the promise of these nanocarriers is very high, in the clinic the effectivity is rather limited. Determining the in vivo fate of the micelles can greatly help to improve this treatment. Here, a simple and fast chelator-free method for...journal article 2022
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Chen, Y. (author)Single-photon emission computed tomography (SPECT) is a well-established nuclear imaging modality for studying functional and pathological properties of the brain. Conventional general purpose SPECT systems typically offer a spatial resolution of about 10 mm with a sensitivity of 0.01-0.02%. A few dedicated brain SPECT scanners have been...doctoral thesis 2021
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Nguyen, M.P. (author)Molecular imaging aims for the visualisation, characterisation, and quantification of biological processes in humans and other living systems at the molecular and cellular level. For today’s patient care, molecular imaging allows for (early) detection and characterisation of disease, efficient planning and assessment of treatments, and...doctoral thesis 2021
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Brown, J.M.C. (author)Over the last decade one of the most significant technological advances made in the field of radiation detectors for nuclear medicine was the development of Silicon Photomultipler (SiPM) sensors. At present only a small number of SiPM based radiation detectors for Single Photon Emission Computed Tomography (SPECT) applications have been...journal article 2021
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Nguyen, M.P. (author), Goorden, M.C. (author), Ramakers, R.M. (author), Beekman, F.J. (author)The use of multi-pinhole collimation has enabled ultra-high-resolution imaging of SPECT and PET tracers in small animals. Key for obtaining high-quality images is the use of statistical iterative image reconstruction with accurate energy-dependent photon transport modelling through collimator and detector. This can be incorporated in a system...journal article 2021
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Chen, Y. (author), Goorden, M.C. (author), Beekman, F.J. (author)SPECT imaging with 123I-FP-CIT is used for diagnosis of neurodegenerative disorders like Parkinson's disease. Attenuation correction (AC) can be useful for quantitative analysis of 123I-FP-CIT SPECT. Ideally, AC would be performed based on attenuation maps (μ-maps) derived from perfectly registered CT scans. Such μ-maps, however, are most...journal article 2021
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Van der Heiden, K. (author), Barrett, H. E. (author), van Gaalen, K.C. (author), Krenning, B. J. (author), Beekman, F.J. (author), Verhagen, H. J.M. (author), Norenberg, J. P. (author), de Jong, M. (author), Gijsen, F.J.H. (author)Background: Calcification and inflammation are atherosclerotic plaque compositional biomarkers that have both been linked to stroke risk. The aim of this study was to evaluate their co-existing prevalence in human carotid plaques with respect to plaque phenotype to determine the value of hybrid imaging for the detection of these biomarkers....journal article 2021
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Wang, B. (author)Breast cancer, being the most common cancer among females, is nowadays routinely diagnosed using X-ray mammography. Though this technique has proven its effectiveness in many cases, X-ray mammography has some disadvantages like reduced diagnostic sensitivity for dense breasts, need for strong breast compression and inability to assess tissues at...doctoral thesis 2020
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Nguyen, M.P. (author), Ramakers, R.M. (author), Kamphuis, Chris (author), Koustoulidou, Sofia (author), Goorden, M.C. (author), Beekman, F.J. (author)Introduction: Autoradiography is an established technique for high-resolution imaging of radiolabelled molecules in biological tissue slices. Unfortunately, creating a 3D image from a set of these 2D images is extremely time-consuming and error-prone. MicroSPECT systems provide such 3D images but have a low resolution. Here we present EXIRAD...journal article 2020
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Barrett, Hilary E. (author), Meester, Eric J. (author), van Gaalen, Kim (author), van der Heiden, Kim (author), Krenning, Boudewijn J. (author), Beekman, F.J. (author), Verhagen, H. J. (author), de Jong, M. (author), Gijsen, F.J.H. (author)Purpose: Atherosclerotic plaque development and progression signifies a complex inflammatory disease mediated by a multitude of proinflammatory leukocyte subsets. Using single photon emission computed tomography (SPECT) coupled with computed tomography (CT), this study tested a new dual-isotope acquisition protocol to assess each radiotracer...journal article 2020
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Goorden, M.C. (author), Kamphuis, Chris (author), Ramakers, R.M. (author), Beekman, F.J. (author)Today, versatile emission computed tomography (VECTor) technology using dedicated high-energy collimation enables simultaneous positron emission tomography (PET) and single photon emission computed tomography (SPECT) down to 0.6 mm and 0.4 mm resolution in mice, respectively. We recently showed that for optimal resolution and quantitative...journal article 2020
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Nguyen, M.P. (author), Goorden, M.C. (author), Beekman, F.J. (author)We recently developed a dedicated focusing multi-pinhole collimator for a stationary SPECT system that offers down to 120 m (or 1.7 nL) spatial resolution SPECT images of cryo-cooled tissue samples (EXIRAD-3D). This collimator is suitable for imaging isotopes that are often used in small animal and diagnostic SPECT such as 125I (27 keV),...journal article 2020
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Ozsahin, Ilker (author), Chen, Ling (author), Könik, Arda (author), King, Michael A. (author), Beekman, F.J. (author), Mok, Greta S.P. (author)Single photon emission computed tomography (SPECT) is an important imaging modality for various applications in nuclear medicine. The use of multi-pinhole (MPH) collimators can provide superior resolution-sensitivity trade-off when imaging small field-of-view compared to conventional parallel-hole and fan-beam collimators. Besides the very...review 2020
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Wang, B. (author), van Roosmalen, J. (author), Kreuger, R. (author), Huizenga, J. (author), Beekman, F.J. (author), Goorden, M.C. (author)In recent years, breast imaging using radiolabelled molecules has attracted significant interest. Our group has proposed a multi-pinhole molecular breast tomosynthesis (MP-MBT) scanner to obtain 3D functional molecular breast images at high resolutions. After conducting extensive optimisation studies using simulations, we here present a first...journal article 2020
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Nguyen, M.P. (author), Goorden, M.C. (author), Kamphuis, Chris (author), Beekman, F.J. (author)Pinhole collimation is widely recognized for offering superior resolution-sensitivity trade-off in SPECT imaging of small subjects. The newly developed EXIRAD-3D autoradiography technique (MILabs B.V.) based on a highly focusing multi-pinhole collimator achieves micron-resolution SPECT for cryo-cooled tissue samples. For such high resolutions...journal article 2019