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Voinea, Cristina (author), Marin, L. (author), Vică, Constantin (author)In this paper we introduce the concept of attentional scaffolds and show the resemblance between social media platforms and slot machines, both functioning as hostile attentional scaffolds. The first section establishes the groundwork for the concept of attentional scaffolds and draws parallels to the mechanics of slot machines, to argue that...journal article 2024
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Hepsaydir, Leyla (author)This research is rooted in defining the marginlands of Istanbul; comprised of the city’s backstages, cracks, and fissures. It proposes an intervention along the historic margins of the city’s Land Walls, now swallowed by urban sprawl and existing as an interstitial inner-city threshold. The lands of such margins harbour an air of latency, having...master thesis 2023
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kadel, Himanshu (author)The brain is the most intricate organ in the human body, yet the underlying mechanisms of its cells and networks are not fully mapped. In addition to this lack of understanding, there are numerous neurological disorders and diseases for which a cure remains elusive. There has been persistent research to understand how neuronal cells function...master thesis 2023
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- Kuo, Chihao (author) master thesis 2023
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Dong, J. (author)The treatment of largy bone defect remains challenging in clinics. All the clinically available bone grafts have their own limitations and are not ideal for the treatment. Therefore, developing a new generation of suitable bone substitutes is urgently needed. In the recent years, porous magnesium (Mg) has been extensively studied for orthopedic...doctoral thesis 2023
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Putra, N.E. (author)The treatment of large bone injuries continues to be challenging partially due to the limited quantity and quality of bone-replacing materials. Iron (Fe) and its alloys have been developed as a group of load-bearing biomaterials. Recent advances in additive manufacturing (AM) have enhanced the potential of Fe-based biomaterials as biodegradable...doctoral thesis 2023
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Pagani, Stefania (author), Salerno, Manuela (author), Filardo, Giuseppe (author), Locs, Janis (author), van Osch, G.J.V.M. (author), Vecstaudza, Jana (author), Dolcini, Laura (author), Borsari, Veronica (author), Fini, Milena (author), Giavaresi, Gianluca (author), Columbaro, Marta (author)Osteochondral lesions, when not properly treated, may evolve into osteoarthritis (OA), especially in the elderly population, where altered joint function and quality are usual. To date, a collagen/collagen–magnesium–hydroxyapatite (Col/Col-Mg-HAp) scaffold (OC) has demonstrated good clinical results, although suboptimal subchondral bone...journal article 2023
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Putra, N.E. (author), Leeflang, M.A. (author), Klimopoulou, M. (author), Dong, J. (author), Taheri, P. (author), Huan, Z. (author), Fratila-Apachitei, E.L. (author), Mol, J.M.C. (author), Chang, J. (author), Zhou, J. (author), Zadpoor, A.A. (author)The development of biodegradable Fe-based bone implants has rapidly progressed in recent years. Most of the challenges encountered in developing such implants have been tackled individually or in combination using additive manufacturing technologies. Yet not all the challenges have been overcome. Herein, we present porous FeMn-akermanite...journal article 2023
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Smit, Thijs (author), Koppen, S. (author), Ferguson, Stephen J. (author), Helgason, Benedikt (author)A promising new treatment for large and complex bone defects is to implant specifically designed and additively manufactured synthetic bone scaffolds. Optimizing the scaffold design can potentially improve bone in-growth and prevent under- and over-loading of the adjacent tissue. This study aims to optimize synthetic bone scaffolds over...journal article 2023
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Klapwijk, R.M. (author), Stables, Kay (author)In this chapter we focus on the importance of the human capacity of design capability and how this can be fostered through design and technology education. Historic undervaluing of developing design capability in formal schooling is highlighted and counteracted by identifying recent recognition of embodied cognition and the role design education...book chapter 2023
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Fokker, Marike (author)Bone defects are a common problem in healthcare today. When the damage is too extensive, the human body is not able to heal itself. Different solutions are available, but they all have limitations. Therefore, the search for a solution to overcome these limitations is important. In this theses a way to create a scaffold out of seperate crumpled...master thesis 2022
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Veldkamp, Dian (author)The central nervous system has a very limited capacity to regenerate damaged tissue. Therefore, regeneration strategies focus on transplantation of neural stem cells or differentiated neural cells. In order to make such a treatment effective, it is important to understand the mechanisms that enable cell differentiation. It is well known that...master thesis 2022
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Bhairo, Ayesha (author)Breast cancer is one of the most dangerous forms of cancer worldwide. Continuous research is therefore essential in order to find realistic treatment options. 3D tumor spheroids have been proven to imitate the structural and physiological TME of in vivo tumors relatively more accurate than the more widely used 2D cell cultures.<br/>During this...bachelor thesis 2022
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Sharaf, A.M.S.E. (author), Roos, B. (author), Timmerman, Raissa (author), Kremers, Gert-Jan (author), Bajramovic, Jeffrey John (author), Accardo, A. (author)Microglia are the resident macrophages of the central nervous system and contribute to maintaining brain’s homeostasis. Current 2D “petri-dish” in vitro cell culturing platforms employed for microglia, are unrepresentative of the softness or topography of native brain tissue. This often contributes to changes in microglial morphology, exhibiting...journal article 2022
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Ganjian, M. (author), Janbaz, S. (author), van Manen, T. (author), Tümer, N. (author), Modaresifar, K. (author), Minneboo, M.B. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)We designed and fabricated a simple setup for the controlled crumpling of nanopatterned, surface-porous flat metallic sheets for the fabrication of volume-porous biomaterials and showed that crumpling can be considered as an efficient alternative to origami-inspired folding. Before crumpling, laser cutting was used to introduce pores to the...journal article 2022
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Dong, J. (author), Lin, P. (author), Putra, N.E. (author), Tümer, N. (author), Leeflang, M.A. (author), Huan, Z. (author), Fratila-Apachitei, E.L. (author), Chang, J. (author), Zadpoor, A.A. (author), Zhou, J. (author)The treatment of femoral nonunion with large segmental bone defect is still challenging. Although magnesium alloys have been considered potential materials for such a treatment, their application is limited by their fast degradation. Adding bioceramic particles into magnesium to form Mg-matrix composites is a promising strategy to adjust...journal article 2022
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Putra, N.E. (author), Borg, K. G.N. (author), Diaz Payno, P.J. (author), Leeflang, M.A. (author), Klimopoulou, M. (author), Taheri, P. (author), Mol, J.M.C. (author), Fratila-Apachitei, E.L. (author), Zhou, J. (author), Zadpoor, A.A. (author)Advanced additive manufacturing techniques have been recently used to tackle the two fundamental challenges of biodegradable Fe-based bone-substituting materials, namely low rate of biodegradation and insufficient bioactivity. While additively manufactured porous iron has been somewhat successful in addressing the first challenge, the limited...journal article 2022
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Neves Leal Costa, B. (author), Adão, Ricardo M.R. (author), Maibohm, Christian (author), Accardo, A. (author), Cardoso, Vanessa F. (author), Nieder, Jana B. (author)Biomimicking biological niches of healthy tissues or tumors can be achieved by means of artificial microenvironments, where structural and mechanical properties are crucial parameters to promote tissue formation and recreate natural conditions. In this work, three-dimensional (3D) scaffolds based on woodpile structures were fabricated by two...journal article 2022
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Putra, N.E. (author), Tigrine, A. (author), Aksakal, S. (author), de la Rosa, V. R. (author), Taheri, P. (author), Fratila-Apachitei, E.L. (author), Mol, J.M.C. (author), Zhou, J. (author), Zadpoor, A.A. (author)Additively manufacturing of porous iron offers a unique opportunity to increase its biodegradation rate by taking advantage of arbitrarily complex porous structures. Nevertheless, achieving the required biodegradation profile remains challenging due to the natural passivation of iron that decrease the biodegradation rate. Moreover, the...journal article 2022
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Dong, J. (author), Tümer, N. (author), Leeflang, M.A. (author), Taheri, P. (author), Fratila-Apachitei, E.L. (author), Mol, J.M.C. (author), Zadpoor, A.A. (author), Zhou, J. (author)Porous biodegradable Mg and its alloys are considered to have a great potential to serve as ideal bone substitutes. The recent progress in additive manufacturing (AM) has prompted its application to fabricate Mg scaffolds with geometrically ordered porous structures. Extrusion-based AM, followed by debinding and sintering, has been recently...journal article 2022