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Lai, Marco (author), van der Stel, Stefan D. (author), Groen, Harald C. (author), van Gastel, Mark (author), Kuhlmann, Koert F.D. (author), Ruers, Theo J.M. (author), Hendriks, B.H.W. (author)Surgical excision is the golden standard for treatment of intestinal tumors. In this surgical procedure, inadequate perfusion of the anastomosis can lead to postoperative complications, such as anastomotic leakages. Imaging photoplethysmography (iPPG) can potentially provide objective and real-time feedback of the perfusion status of tissues....journal article 2022
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Geldof, Freija (author), Jong, Lynn-Jade (author), Dashtbozorg, Behdad (author), Hendriks, B.H.W. (author), Sterenborg, Henricus J.C.M. (author), Ruers, Theo J.M. (author)Establishing adequate resection margins during colorectal cancer surgery is challenging. Currently, in up to 30% of the cases the tumor is not completely removed, which emphasizes the lack of a real-time tissue discrimination tool that can assess resection margins up to multiple millimeters in depth. Therefore, we propose to combine spectral...conference paper 2021
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De Boer, Lisanne L. (author), Kho, Esther (author), Józwiak, Katarzyna (author), Van De Vijver, Koen K. (author), Vrancken Peeters, Marie Jeanne T.F.D. (author), Van Duijnhoven, Frederieke (author), Hendriks, B.H.W. (author), Sterenborg, Henricus J.C.M. (author), Ruers, Theo J.M. (author)Diffuse reflectance spectroscopy (DRS) can discriminate different tissue types based on optical characteristics. Since this technology has the ability to detect tumor tissue, several groups have proposed to use DRS for margin assessment during breast-conserving surgery for breast cancer. Nowadays, an increasing number of patients with breast...journal article 2019
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De Boer, Lisanne L. (author), Bydlon, Torre M. (author), Van Duijnhoven, Frederieke (author), Vranken Peeters, Marie Jeanne T.F.D. (author), Loo, Claudette E. (author), Winter-Warnars, Gonneke A.O. (author), Sanders, Joyce (author), Sterenborg, Henricus J.C.M. (author), Hendriks, B.H.W. (author), Ruers, Theo J.M. (author)Background: Breast cancer surgeons struggle with differentiating healthy tissue from cancer at the resection margin during surgery. We report on the feasibility of using diffuse reflectance spectroscopy (DRS) for real-time in vivo tissue characterization. Methods: Evaluating feasibility of the technology requires a setting in which...journal article 2018
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Toward complete oral cavity cancer resection using a handheld diffuse reflectance spectroscopy probeBrouwer de Koning, Susan G. (author), Baltussen, Elisabeth J.M. (author), Karakullukcu, M. Baris (author), Dashtbozorg, Behdad (author), Smit, Laura A. (author), Dirven, Richard (author), Hendriks, B.H.W. (author), Sterenborg, Henricus J.C.M. (author), Ruers, Theo J.M. (author)This ex-vivo study evaluates the feasibility of diffuse reflectance spectroscopy (DRS) for discriminating tumor from healthy tissue, with the aim to develop a technology that can assess resection margins for the presence of tumor cells during oral cavity cancer surgery. Diffuse reflectance spectra were acquired on fresh surgical specimens...journal article 2018
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Baltussen, Elisabeth J.M. (author), Snaebjornsson, Petur (author), De Koning, Susan G.Brouwer (author), Sterenborg, Henricus J.C.M. (author), Aalbers, Arend G.J. (author), Kok, Niels (author), Beets, Geerard L. (author), Hendriks, B.H.W. (author), Kuhlmann, Koert F.D. (author), Ruers, Theo J.M. (author)Colorectal surgery is the standard treatment for patients with colorectal cancer. To overcome two of the main challenges, the circumferential resection margin and postoperative complications, real-time tissue assessment could be of great benefit during surgery. In this ex vivo study, diffuse reflectance spectroscopy (DRS) was used to...journal article 2017