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Slijkhuis, Nuria (author), Razzi, F. (author), Korteland, Suze Anne (author), Heijs, Bram (author), van Gaalen, Kim (author), Duncker, Dirk J. (author), van der Steen, A.F.W. (author), van Steijn, V. (author), van Beusekom, Heleen M.M. (author), van Soest, G. (author)Coronary atherosclerosis is caused by plaque build-up, with lipids playing a pivotal role in its progression. However, lipid composition and distribution within coronary atherosclerosis remain unknown. This study aims to characterize lipids and investigate differences in lipid composition across disease stages to aid in the understanding of...journal article 2024
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Slijkhuis, Nuria (author), Mirzaian, Mina (author), Korteland, Suze Anne (author), Heijs, Bram (author), van Gaalen, Kim (author), Nieuwenhuizen, Ingeborg (author), van der Heiden, Kim (author), Claude, Emmanuelle (author), van Soest, G. (author)Background and aims: Lipids play an important role in atherosclerotic plaque development and are interesting candidate predictive biomarkers. However, the link between circulating lipids, accumulating lipids in the vessel wall, and plaque destabilization processes in humans remains largely unknown. This study aims to provide new insights into...journal article 2023
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Tziotziou, Aikaterini (author), Hartman, Eline (author), Korteland, Suze Anne (author), van der Lugt, Aad (author), van der Steen, A.F.W. (author), Daemen, Joost (author), Bos, Daniel (author), Wentzel, Jolanda (author), Akyildiz, A.C. (author)Background and aims: Atherosclerotic plaque onset and progression are known to be affected by local biomechanical factors. While the role of wall shear stress (WSS) has been studied, the impact of another biomechanical factor, namely mechanical wall stress (MWS), remains poorly understood. In this study, we investigated the association of MWS...journal article 2023
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Torun, Su Guvenir (author), Munoz, Pablo de Miguel (author), Crielaard, Hanneke (author), Verhagen, Hence J.M. (author), Kremers, Gert Jan (author), van der Steen, A.F.W. (author), Akyildiz, A.C. (author)Atherosclerotic plaque rupture in carotid arteries is a major cause of cerebrovascular events. Plaque rupture is the mechanical failure of the heterogeneous fibrous plaque tissue. Local characterization of the tissue's failure properties and the collagen architecture are of great importance to have insights in plaque rupture for clinical...journal article 2023
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Moerman, A. M. (author), Korteland, S. (author), Dilba, K. (author), van Gaalen, K. (author), Poot, D. H.J. (author), van Der Lugt, A. (author), Verhagen, H. J.M. (author), Wentzel, J. J. (author), van Der Steen, A. F.W. (author), Gijsen, F.J.H. (author), Van der Heiden, K. (author)The role of wall shear stress (WSS) in atherosclerotic plaque development is evident, but the relation between WSS and plaque composition in advanced atherosclerosis, potentially resulting in plaque destabilization, is a topic of discussion. Using our previously developed image registration pipeline, we investigated the relation between two...journal article 2022
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Guvenir Torun, Su (author), Torun, Hakki M. (author), Hansen, Hendrik H.G. (author), de Korte, Chris L. (author), van der Steen, Antonius F.W. (author), Gijsen, F.J.H. (author), Akyildiz, A.C. (author)Objective: Plaque rupture in atherosclerotic carotid arteries is a main cause of ischemic stroke and it is correlated with high plaque stresses. Hence, analyzing stress patterns is essential for plaque specific rupture risk assessment. However, the critical information of the multicomponent material properties of atherosclerotic carotid...journal article 2022
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Gijsen, F.J.H. (author), Vis, Bas (author), Barrett, Hilary E. (author), Zadpoor, A.A. (author), Verhagen, Hence J. (author), Bos, Daniel (author), van der Steen, A.F.W. (author), Akyildiz, A.C. (author)Objective: Atherosclerotic plaque rupture in carotid arteries is a major source of cerebrovascular events. Calcifications are highly prevalent in carotid plaques, but their role in plaque rupture remains poorly understood. This work studied the morphometric features of calcifications in carotid plaques and their effect on the stress...journal article 2021
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Razzi, F. (author), Lovrak, M. (author), Gruzdyte, Dovile (author), Den Hartog, Yvette (author), Duncker, Dirk J. (author), van Esch, J.H. (author), van Steijn, V. (author), van Beusekom, Heleen M.M. (author)Atherosclerotic arteries are commonly treated using drug-eluting stents (DES). However, it remains unclear whether and how the properties of atherosclerotic plaque affect drug transport in the arterial wall. A limitation of the currently used atherosclerotic animal models to study arterial drug distribution is the unpredictability of plaque...journal article 2021
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Guvenir Torun, Su (author), Torun, Hakki M. (author), Hansen, Hendrik H.G. (author), Gandini, Giulia (author), Berselli, Irene (author), Codazzi, Veronica (author), de Korte, Chris L. (author), van der Steen, A.F.W. (author), Migliavacca, Francesco (author), Chiastra, Claudio (author), Akyildiz, A.C. (author)Atherosclerotic plaque rupture in coronary arteries, an important trigger of myocardial infarction, is shown to correlate with high levels of pressure-induced mechanical stresses in plaques. Finite element (FE) analyses are commonly used for plaque stress assessment. However, the required information of heterogenous material properties of...journal article 2021
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Barrett, Hilary E. (author), Meester, Eric J. (author), van Gaalen, Kim (author), van der Heiden, Kim (author), Krenning, Boudewijn J. (author), Beekman, F.J. (author), Verhagen, H. J. (author), de Jong, M. (author), Gijsen, F.J.H. (author)Purpose: Atherosclerotic plaque development and progression signifies a complex inflammatory disease mediated by a multitude of proinflammatory leukocyte subsets. Using single photon emission computed tomography (SPECT) coupled with computed tomography (CT), this study tested a new dual-isotope acquisition protocol to assess each radiotracer...journal article 2020
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Selwaness, Mariana (author), Hameeteman, Reinhard (author), Van 't Klooster, Ronald (author), Van den Bouwhuijsen, Quirijn (author), Hofman, Albert (author), Franco, Oscar H. (author), Niessen, W.J. (author), Klein, Stefan (author), Vernooij, Meike W. (author), Van der Lugt, Aad (author), Wentzel, Jolanda J. (author)Background and aims In a large stroke-free population, we sought to identify cardiovascular risk factors and carotid plaque components associated with carotid plaque burden, lumen volume and stenosis. Methods The carotid arteries of 1562 stroke-free participants from The Rotterdam Study were imaged on a 1.5-Tesla MRI scanner. Inner and outer...journal article 2016
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Atherosclerotic plaque fibrous cap assessment under an oblique scan plane orientation in carotid MRINieuwstadt, H.A. (author), Van der Lugt, A. (author), Kassar, Z.A.M. (author), Breeuwer, M. (author), Van der Steen, A.F.W. (author), Gijsen, F.J.H. (author)Carotid magnetic resonance imaging (MRI) is used to noninvasively assess atherosclerotic plaque fibrous cap (FC) status, which is closely related to ischemic stroke. Acquiring anisotropic voxels improves in-plane visualization, however, an oblique scan plane orientation could then obscure a FC (i.e., contrast below the noise level) and thus...journal article 2014
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Jansen, K. (author), Van Soest, G. (author), Van der Steen, A.F.W. (author)The vulnerable atherosclerotic plaque is believed to be at the root of the majority of acute coronary events. Even though the exact origins of plaque vulnerability remain elusive, the thin-cap fibroatheroma, characterized by a lipid-rich necrotic core covered by a thin fibrous cap, is considered to be the most prominent type of vulnerable plaque...journal article 2014
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Jansen, K. (author), Wu, M. (author), Van der Steen, A.F.W. (author), Van Soest, G. (author)Spectroscopic intravascular photoacoustic imaging (sIVPA) has shown promise to detect and distinguish lipids in atherosclerotic plaques. sIVPA generally utilizes one of the two high absorption bands in the lipid absorption spectrum at 1.2 ?m and 1.7 ?m. Specific absorption signatures of various lipid compounds within the bands in either...journal article 2014
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Jansen, K. (author), Van der Steen, A.F.W. (author), Wu, M. (author), Van Beusekom, H.M.M. (author), Springeling, G. (author), Li, X. (author), Zhou, Q. (author), Shung, K.K. (author), De Kleijn, D.P.V. (author), Van Soest, G. (author)The natural history of atherosclerosis is marked by changes in the lipid biochemistry in the diseased arterial wall. As lesions become more vulnerable, different cholesterol species accumulate in the plaque. Understanding unstable atherosclerosis as a pharmacological and interventional therapeutic target requires chemically specific imaging of...journal article 2014
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Carvalho, D.D.B. (author), Klein, S. (author), Akkus, Z. (author), Ten Kate, G.L. (author), Schinkel, A.F.L. (author), Bosch, J.G. (author), Van der Lugt, A. (author), Niessen, W.J. (author)Purpose The purpose of this paper is to present a methodology to estimate the carotid artery lumen centerlines in ultrasound (US) images obtained in a free-hand examination. Challenging aspects here are speckle noise in US images, artifacts, and the lack of contrast in the direction orthogonal to the US beam direction. Method An algorithm based...journal article 2011