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Kurucz, Liza (author)Prostate cancer is the most commonly diagnosed cancer in the Netherlands. Accurate assessment of the prostate volume (PV) is a crucial step in prostate cancer (PCa) screening and risk-stratification. In standard clinical care, the PV is obtained by measuring the prostate dimensions with the aid of transrectal ultrasound (TRUS). However, rectal...master thesis 2024
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Wang, R. (author)Radionuclide therapy is an important cancer treatment modality that makes use of the local irradiation from radionuclides at the tumor sites. Radiopharmaceuticals are normally composed of three components: radionuclide, carrier and tumor targeting agent. In terms of the radionuclide carriers, macrocyclic and acyclic chelators are commonly used...doctoral thesis 2024
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Dirks, Remco (author)Brachytherapy (BT) is an essential component in the curative treatment of cervical cancer. With commercial BT implant devices, called applicators, the radioactive sources can only be positioned in fixed intracavitary channels or in a fixed array of interstitial needles. Patient-tailored BT applicators containing individualised needle channels...master thesis 2024
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Bruggen, Femke (author)Cervical Cancer (CC) is a preventable disease and is easily treated when detected early. Yet it is the second most prevalent cancer related death in Cameroon, causing an estimated 1787 deaths each year (Woks et al, 2023). Cameroon has implemented no national strategy to prevent this disease and so screening practices that are in place are...master thesis 2024
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Wolfkamp, Wouter (author), Meijer, Joyce (author), van Hoeve, Jolanda C. (author), van Erning, Felice (author), de Geus-Oei, L.F. (author), de Hingh, Ignace (author), Veltman, Jeroen (author), Siesling, Sabine (author)Background: In the Netherlands, the COVID-19 pandemic resulted in a temporary halt of population screening for cancer and limited hospital capacity for non-COVID care. We aimed to investigate the impact of the pandemic on the in-hospital diagnostic pathway of breast cancer (BC) and colorectal cancer (CRC). Methods: 71,159 BC and 48,900 CRC...journal article 2024
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van Oossanen, R. (author), Maier, A. (author), Godart, Jérémy (author), Pignol, Jean Philippe (author), Denkova, A.G. (author), van Rhoon, Gerard C. (author), Djanashvili, K. (author)Objective: To investigate the potential of hybrid Pd/Fe-oxide magnetic nanoparticles designed for thermo-brachytherapy of breast cancer, considering their specific loss power (SLP) and clinical constraints in the applied magnetic field. Methods: Hybrid nanoparticles consisting of palladium-core and iron oxide shell of increasing thickness,...journal article 2024
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Straathof, R. (author), Meijaard, J.P. (author), Perez, S.M. (author), Kolkman-Deurloo, Inger Karine K. (author), Nout, Remi A. (author), Heijmen, Ben J.M. (author), Wauben, L.S.G.L. (author), Dankelman, J. (author), van de Berg, N.J. (author)Background: The steep radiation dose gradients in cervical cancer brachytherapy (BT) necessitate a thorough understanding of the behavior of afterloader source cables or needles in the curved channels of (patient-tailored) applicators. Purpose: The purpose of this study is to develop and validate computer models to simulate: (1) BT source...journal article 2024
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Keeping your best options open with AI-based treatment planning in prostate and cervix brachytherapyDickhoff, Leah R.M. (author), Scholman, R.J. (author), Barten, Danique L.J. (author), Kerkhof, Ellen M. (author), Roorda, Jelmen J. (author), Velema, Laura A. (author), Stalpers, Lukas J.A. (author), Pieters, Bradley R. (author), Bosman, P.A.N. (author), Alderliesten, T. (author)PURPOSE: Without a clear definition of an optimal treatment plan, no optimization model can be perfect. Therefore, instead of automatically finding a single “optimal” plan, finding multiple, yet different near-optimal plans, can be an insightful approach to support radiation oncologists in finding the plan they are looking for. METHODS AND...review 2024
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Oud, Michelle (author), Breedveld, Sebastiaan (author), Rojo-Santiago, Jesús (author), Giżyńska, Marta Krystyna (author), Kroesen, Michiel (author), Habraken, S.J.M. (author), Perko, Z. (author), Heijmen, Ben (author), Hoogeman, M.S. (author)Objective. In head-and-neck cancer intensity modulated proton therapy, adaptive radiotherapy is currently restricted to offline re-planning, mitigating the effect of slow changes in patient anatomies. Daily online adaptations can potentially improve dosimetry. Here, a new, fully automated online re-optimization strategy is presented. In a...journal article 2024
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Starmans, M.P.A. (author), Miclea, Razvan L. (author), Vilgrain, Valerie (author), Ronot, Maxime (author), Purcell, Yvonne (author), Verbeek, Jef (author), Niessen, W.J. (author), Klein, Stefan (author), Thomeer, Maarten G. (author)Rationale and Objectives: Distinguishing malignant from benign liver lesions based on magnetic resonance imaging (MRI) is an important but often challenging task, especially in noncirrhotic livers. We developed and externally validated a radiomics model to quantitatively assess T2-weighted MRI to distinguish the most common malignant and...journal article 2024
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Battaglia, Thomas W. (author), Mimpen, Iris L. (author), Traets, Joleen J.H. (author), van Hoeck, Arne (author), Zeverijn, Laurien J. (author), Geurts, Birgit S. (author), de Wit, Gijs F. (author), Vos, Joris L. (author), Wessels, L.F.A. (author)Microbial communities are resident to multiple niches of the human body and are important modulators of the host immune system and responses to anticancer therapies. Recent studies have shown that complex microbial communities are present within primary tumors. To investigate the presence and relevance of the microbiome in metastases, we...journal article 2024
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van Strien-Knippenberg, Inge S. (author), Arjangi-Babetti, Hannah (author), Timmermans, Danielle R.M. (author), Schrauwen, Laura (author), Fransen, M.P. (author), Melles, M. (author), Damman, Olga C. (author)Background: Risk-based breast cancer (BC) screening raises new questions regarding information provision and risk communication. This study aimed to: 1) investigate women’s beliefs and knowledge (i.e., mental models) regarding BC risk and (risk-based) BC screening in view of implications for information development; 2) develop novel...journal article 2024
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de Vries, M. (author), Christianen, M. E.M.C. (author), Luthart, L. (author), de Vries, K. C. (author), Kolkman-Deurloo, I. K.K. (author), van den Dobbelsteen, J.J. (author)Prostate cancer patients with an enlarged prostate and/or excessive pubic arch interference (PAI) are generally considered non-eligible for high-dose-rate (HDR) brachytherapy (BT). Steerable needles have been developed to make these patients eligible again. This study aims to validate the dosimetric impact and performance of steerable needles...journal article 2024
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Vaz, Sofia C. (author), Woll, John Patrick Pilkington (author), Cook, Gary J.R. (author), Ulaner, Gary A. (author), Jacene, Heather (author), Schoones, Jan W. (author), Peeters, Marie Jeanne Vrancken (author), Mann, Ritse M. (author), Dibble, Elizabeth H. (author), de Geus-Oei, L.F. (author)Introduction: There is much literature about the role of 2-[<sup>18</sup>F]FDG PET/CT in patients with breast cancer (BC). However, there exists no international guideline with involvement of the nuclear medicine societies about this subject. Purpose: To provide an organized, international, state-of-the-art, and multidisciplinary guideline,...journal article 2024
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Mazzola, Sergio (author), Vittorietti, M. (author), Fruscione, Santo (author), De Bella, Daniele Domenico (author), Savatteri, Alessandra (author), Belluzzo, Miriam (author), Ginevra, Daniela (author), Gioia, Alice (author), Costanza, Davide (author), Castellone, Maria Domenica (author), Costantino, Claudio (author), Zarcone, Maurizio (author), Ravazzolo, Barbara (author), Graziano, Giorgio (author), Mannino, Rita (author), Amodio, Rosalba (author), Di Marco, Vito (author), Vitale, Francesco (author), Mazzucco, Walter (author)A retrospective observational study utilising cancer incidence data from a population-based registry investigated determinants affecting primary liver cancer survival in a southern Italian region with high hepatitis viral infection rates and obesity prevalence. Among 2687 patients diagnosed between 2006 and 2019 (65.3% male), a flexible hazard...journal article 2024
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Greeven, Julia (author)Liver cancer ranks seventh in global cancer prevalence and stands as the third leading cause of cancer-related deaths. Surgical resection is considered the gold standard for treatment of liver malignancies and has witnessed a shift toward minimally invasive techniques in recent decades. Surgeons rely on laparoscopic observations, preoperative...master thesis 2023
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Frison, Sebastian (author)Hepatopancreato-biliary (HPB) surgeons, when planning complex cases of pancreatic cancer, lose precious time because of difficulties in visualising the interaction between tumour and blood vessels and identifying patient-specific anatomy. To tackle this issue, the Integrated Imaging Workstation (IIW) was prototyped by e/MTIC and Philips. This...master thesis 2023
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Brouwer, Niek (author)The tumor composition of breast cancer determines how tumors behave. Yet, there is a limited understanding of the arrangement of tumor cells in relation to cells in the tumor microenvironment (TME). In this research, we have characterized distance relationships between 324 cell-type pairs in 749 tissue samples of the Molecular Taxonomy of Breast...master thesis 2023
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Patandin, Ayush (author)Colorectal cancer is a widespread disease that significantly impacts the health of individuals worldwide. Understanding the needs and concerns of those affected by this disease is crucial for improving patient outcomes and enhancing the quality of care. Patient web forums have emerged as valuable platforms for individuals to openly share their...master thesis 2023
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Engelberts, Rutger (author)With breast cancer being the leading cause of death in the Netherlands, while also being expected to have double the amount of cases in the next ten years, it is vital that treatment is optimised. Over the last decade, research has been done to incorporate mathematical modelling in this process, especially in the case of HER2+ breast cancer...master thesis 2023