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Gil Jimenez, A. (author), van Dorp, Jeroen (author), Contreras-Sanz, Alberto (author), van der Vos, Kristan (author), Vis, Daniel J. (author), Braaf, Linde (author), Broeks, Annegien (author), Kerkhoven, Ron (author), van Kessel, Kim E.M. (author), Wessels, L.F.A. (author)Cisplatin-based neoadjuvant chemotherapy (NAC) followed by radical cystectomy is recommended for patients with muscle-invasive bladder cancer (MIBC). It has been shown that somatic deleterious mutations in ERCC2, gain-of-function mutations in ERBB2, and alterations in ATM, RB1, and FANCC are correlated with pathological response to NAC in...journal article 2023
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Driessen, Helen P.A. (author), Busschbach, Jan J.V. (author), Van Der Rijt, Carin C.D. (author), Elfrink, Erna J. (author), Raijmakers, Natasja J.H. (author), Van Roij, Janneke (author), Rietjens, J.A.C. (author), Kranenburg, Leonieke W. (author)Objectives: The care needs of patients with advanced cancer and their relatives change throughout the disease trajectory. This study focused on the care-related problems and needs of patients with advanced cancer and their relatives. This was done from the perspective of centres for information and support. Methods: This cross-sectional study...journal article 2023
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Rojo-Santiago, Jesús (author), Korevaar, Erik (author), Perko, Z. (author), Both, Stefan (author), Habraken, S.J.M. (author), Hoogeman, M.S. (author)Background and purpose: In the Netherlands, head-and-neck cancer (HNC) patients are referred for proton therapy (PT) through model-based selection (MBS). However, treatment errors may compromise adequate CTV dose. Our aims are: (i) to derive probabilistic plan evaluation metrics on the CTV consistent with clinical metrics; (ii) to evaluate...journal article 2023
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Kumar, Arun (author), Kumar, Kanhaiya (author), Ali, Mohammad (author), Raj, Vivek (author), Srivastava, Abhinav (author), Kumar, Manishankar (author), Niraj, Pintoo Kumar (author), Kumar, Mukesh (author), Kumar, S. (author)The present study was carried out in the village Kaliprasad of Bhagalpur district of Bihar to know the arsenic exposure effect in the exposed population. A total of n = 102 households were studied, and their water and biological samples such as urine and hair were collected and analyzed in a graphite furnace atomic absorption...journal article 2023
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Tienkamp, Thomas B. (author), van Son, Rob J.J.H. (author), Halpern, B.M. (author)Introduction: Surgical treatment for oral cancer leads to lasting changes of the vocal tract and individuals treated for oral cancer (ITOC) often experience speech problems. The purpose of this study was to analyse the acoustic properties of the spontaneous speech of individuals who were surgically treated for oral cancer. It was investigated...journal article 2023
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van Tienderen, Gilles S. (author), Conboy, J.P. (author), Muntz, I.A.A. (author), Willemse, Jorke (author), Tieleman, Jantine (author), Monfils, Kathryn (author), Schurink, Ivo J. (author), Demmers, J.A.A. (author), Koenderink, G.H. (author)Tumor initiation and progression are critically dependent on interaction of cancer cells with their cellular and extracellular microenvironment. Alterations in the composition, integrity, and mechanical properties of the extracellular matrix (ECM) dictate tumor processes including cell proliferation, migration, and invasion. Also in primary...journal article 2023
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Thomsen, L.C.V. (author), Kleinmanns, Katrin (author), Anandan, Shamundeeswari (author), Gullaksen, Stein Erik (author), Abdelaal, T.R.M. (author), Iversen, Grete Alrek (author), Akslen, Lars Andreas (author), McCormack, Emmet (author), Bjørge, Line (author)The prognosis of high-grade serous ovarian carcinoma (HGSOC) is poor, and treatment selection is challenging. A heterogeneous tumor microenvironment (TME) characterizes HGSOC and influences tumor growth, progression, and therapy response. Better characterization with multidimensional approaches for simultaneous identification and...journal article 2023
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Linders, D. G.J. (author), Deken, M. M. (author), van Dam, M. A. (author), Wasser, M. N.J.M. (author), Voormolen, E. M.C. (author), Kroep, J. R. (author), van Dongen, G. A.M.S. (author), Vugts, D. (author), de Geus-Oei, L.F. (author)Background: Approximately 20% of invasive ductal breast malignancies are human epidermal growth factor receptor 2 (HER2)-positive. These patients receive neoadjuvant systemic therapy (NAT) including HER2-targeting therapies. Up to 65% of patients achieve a pathological complete response (pCR). These patients might not have needed surgery....journal article 2023
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Stein, Alexander (author), Salvioli, M. (author), Garjani, Hasti (author), Dubbeldam, J.L.A. (author), Viossat, Yannick (author), Brown, Joel S. (author), Staňková, K. (author)Stackelberg evolutionary game (SEG) theory combines classical and evolutionary game theory to frame interactions between a rational leader and evolving followers. In some of these interactions, the leader wants to preserve the evolving system (e.g. fisheries management), while in others, they try to drive the system to extinction (e.g. pest...journal article 2023
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Fokkinga, E.P. (author), Hernandez-Tamames, J.A. (author), Ianus, Andrada (author), Nilsson, Markus (author), Tax, Chantal M.W. (author), Perez-Lopez, Raquel (author), Grussu, Francesco (author)Diffusion-weighted magnetic resonance imaging (DW-MRI) aims to disentangle multiple biological signal sources in each imaging voxel, enabling the computation of innovative maps of tissue microstructure. DW-MRI model development has been dominated by brain applications. More recently, advanced methods with high fidelity to histology are...review 2023
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Supportive interventions for family caregivers of patients with advanced cancer: A systematic reviewBecqué, Yvonne N. (author), van der Wel, Maaike (author), Aktan-Arslan, Muzeyyen (author), Driel, Anne Geert van (author), Rietjens, J.A.C. (author), van der Heide, Agnes (author), Witkamp, Erica (author)Objective: Family caregivers are often intensively involved in palliative and end-of-life cancer care. A variety of interventions to support family caregivers have been developed, differing in target population, modality, and components. We aimed to systematically examine characteristics and the effectiveness of interventions to support...review 2023
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Halpern, B.M. (author), Feng, S. (author), van Son, Rob (author), van den Brekel, Michiel (author), Scharenborg, O.E. (author)In this paper, we build and compare multiple speech systems for the automatic evaluation of the severity of a speech impairment due to oral cancer, based on spontaneous speech. To be able to build and evaluate such systems, we collected a new spontaneous oral cancer speech corpus from YouTube consisting of 124 utterances rated by 100 non...journal article 2023
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Maasland, Anouk (author)The aim of this thesis is to study the dosimetric feasibility of FLASH proton therapy for early-stage breast cancer patients. The biological effect of FLASH is seen under ultra-high dose-rates conditions and is beneficial in the damage to healthy tissue. The FLASH effect could enable the clinical feasibility of definitive radiotherapy for low...master thesis 2022
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van Oosten, Eva (author)With almost 900.000 new patients per year suffering from head and neck squamous cell carcinomas (HNSCC), who after radiotherapy treatments experience severe side effects, the focus is drawn to proton therapy. Proton therapy results to less side effects since healthy tissues surrounding the tumour receive less radiation dose. This results from...master thesis 2022
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de Groot, Chiel (author)This thesis investigates the tissue sparing effect of FLASH (>40 Gy/s) radiation, as opposed to CONV (conventional, dose rates typically between 0.010.1 Gy/s) radiation. We irradiated zebrafish embryos (4 days past fertilisation) with 116 MeV protons. The aim was (1) to measure the effect, and (2) if the effect were significant, see whether...master thesis 2022
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Ruijs, Laura (author)Pancreatic cancer is one of the deadliest types of cancer and generally has a 5-year survival rate of 5%. Surgery (pancreatoduodenectomy) is the only form of curative treatment for patients diagnosed with pancreatic cancer. If the tumour is operable, the resectability of the tumour depends on the level of tumour-vessel contact. Based on CT scans...master thesis 2022
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van Krimpen, Eline (author)Treatment of early stage breast cancer is generally invasive to a patient's daily life while being treated. Therefore, to diminish the physical and psychological impact during and after recovery, a newly proposed minimally invasive therapy for early-stage breast cancer treatment is proposed. Within this study, this proposed treatment is modelled...master thesis 2022
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Negenman, Eva (author)Purpose: Proton therapy has been proposed as an alternative to conventional photon therapy for the treatment of locally advanced cervical cancer (LACC) since these patients experience toxicities. Proton therapy may allow for significant sparing of the organs at risk, reducing the incidence of treatment-related morbidities. The aim of this study...master thesis 2022
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van Rijckevorsel, Marleen (author)The coming years, demand for healthcare will increase exponentially, resulting in increased pressure on the decreasing number of healthcare providers. A digital transition of healthcare is needed in order to be able to keep offering widely accessible, quality care. <br/><br/>Unfortunately, the healthcare sector has difficulties keeping up with...master thesis 2022
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Slingerland, Eva (author)HER2+ breast cancer patients suffer from aggressive tumours that often respond well to treatment compared to HER2- patients. Currently, patients are all treated with the same number of anti-tumour treatments, although the required number to eradicate all tumour cells varies between patients. The goal is thus to have an individualised model based...master thesis 2022