Definitive treatment for early-stage breast cancer with FLASH proton therapy: Dosimetric feasibility and optimization with intensity-modulated ridge filtered beams and toxicity-model endpoints

The aim of this thesis is to study the dosimetric feasibility of FLASH proton therapy for early-stage breast cancer patients. The biological effect of FLASH is seen under ultra-high dose-rates conditions and is beneficial in the damage to healthy tissue. The FLASH effect could enable the clinical feasibility of definitive radiotherapy for low...

Back to the Future: Towards Ridge Filters in Clinical FLASH Proton Therapy Treatment Planning for Neuro-Oncological Targets

FLASH proton therapy is a growing field of research, especially due to its biological benefits in radiation oncology: sparing healthy tissue while delivering the treatment within a millisecond. However, instead of sparing healthy tissue, the conventional FLASH approach, using transmission beams, damages the tissue behind the...