Towards improved porous models for solid/fluid topology optimization

Modeling of fluid flows in density-based topology optimization forms a longstanding challenge. Methods based on the Navier–Stokes equations with Darcy penalization (NSDP equations) are widely used in fluid topology optimization. These methods use porous materials with low permeability to represent the solid domain. Consequently, they suffer...

Hybrid-dimensional modeling for fluid flow in heterogeneous porous media using dual fracture-pore model with flux interaction of fracture–cavity network

Developing numerical method of fractured porous media is of paramount importance in geoscience applications. Previous studies have revealed that the discrete fractures and cavities as well as the heterogeneity have considerable influences on hydraulic property of porous media. This work presents a numerical investigation on fluid flow in...

Approximate solutions to the optimal flow problem of multi-area integrated electrical and gas systems

We formulate the optimal flow problem in a multi-area integrated electrical and gas system as a mixed-integer optimization problem by approximating the non-linear gas flows with piece-wise affine functions, thus resulting in a set of mixed-integer linear constraints. For its solution, we propose a novel algorithm that consists in one stage for...

Silicification, flow pathways, and deep-seated hypogene dissolution controlled by structural and stratigraphic variability in a carbonate-siliciclastic sequence (Brazil)

Fractured and karstified carbonate units are key exploration targets for the hydrocarbon industry as they represent important reservoirs. Furthermore, large water reserves and geothermal systems are hosted in carbonate aquifers. This paper documents the relationships between stratigraphy, structural patterns, silicification, and the spatial...

Fluid shear stress-induced TGF-β/ALK5 signaling in renal epithelial cells is modulated by MEK1/2

Renal tubular epithelial cells are exposed to mechanical forces due to fluid flow shear stress within the lumen of the nephron. These cells respond by activation of mechano-sensors located at the plasma membrane or the primary cilium, having crucial roles in maintenance of cellular homeostasis and signaling. In this paper, we applied fluid shear...

Telescience and image processing for PODI: An analysis and a proposal for a simulation set-up