document

Design of a stiff suction grasper for Minimally Invasive Surgery: An explorative design study

van Loo, Lars (author)

master thesis 2023

document

MRI-Compatible Pneumatic Actuation Unit for a Self-Propelling Needle

Hoppener, Bruce (author)

Focal laser ablation is a new, promising method to treat tumors. The current focal laser ablation approach is to insert an optical fiber into the patient using rigid needles. A side effect of this approach is that during the needle insertion, tissue damage occurs. The larger the diameter of the needle, the more tissue damage. If the diameter of...

master thesis 2023

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Developing a high-performance patient-to-image registration system for robotic cochlear implant surgery: Through the human-robot interaction-focused design method leading to a multi-modal, multi-feedback admittance control, touch-based pair-point bone-anchored fiducial registration and its performance measured in accuracy, workload, usability and trust

Halman, Susanna (author)

This thesis presents the research to design a successful high-accuracy, sub-millimetric registration method for an autonomous robot equipped to drill bone for cochlear implant (CI) surgery. Its performance, and thus success, is measured in accuracy, workload, usability and trust. While state-of-the-art (STOTA) research lacks the inclusion of...

master thesis 2023

document

The extent to which circular economy principles have been applied in the design of medical devices for low-resource settings in Sub-Saharan Africa.: A systematic review

Samenjo, K.T. (author), Oosting, R.M. (author), Bakker, C.A. (author), Diehl, J.C. (author)

Healthcare facilities in low-resource settings in Sub-Saharan Africa are plagued<br/>with issues of non-functional and obsolete medical devices, which ultimately<br/>end up prematurely disposed of as waste. With increasing healthcare demands,<br/>stopping medical device disposal is imperative. One way to achieve this is<br/>to leverage circular...

journal article 2023

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A circular economy for medical devices; barriers and opportunities for laparoscopic instruments

Hoveling, T. (author), Faludi, Jeremy (author), Bakker, C.A. (author)

conference paper 2023

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Tsetse fly inspired steerable bone drill: a proof of concept

de Kater, E.P. (author), Müller, R. (author), Sakes, A. (author), Breedveld, P. (author)

The fixation strength of pedicle screws could be increased by fixating along the much stronger cortical bone layer, which is not possible with the current rigid and straight bone drills. Inspired by the tsetse fly, a single-plane steerable bone drill was developed. The drill has a flexible transmission using two stacked leaf springs such that...

journal article 2023

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Evaluation of two extraction chromatography resins for scandium and titanium separation for medical isotope production

McLain, Derek R. (author), Brossard, Thomas W. (author), de Kruijff, R.M. (author), Kankanamalage, Pavithra H.A. (author), Rotsch, David A. (author)

Scandium-47 (⁴⁷Sc) can be used in nuclear medicine as a therapeutic-diagnostic, or “theragnostic,” radioactive medical isotope for cancer detection and treatment. The ⁴⁷Sc isotope can be produced through the photonuclear reaction ⁴⁸Ti(γ,p)⁴⁷Sc by irradiating enriched ⁴⁸Ti target material....

journal article 2023

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Introduction of innovations in joint arthroplasty: Recommendations from the ‘EFORT implant and patient safety initiative’

Overgaard, Søren (author), Grupp, Thomas M. (author), Nelissen, R.G.H.H. (author), Cristofolini, Luca (author), Lübbeke, Anne (author), Jäger, Marcus (author), Fink, Matthias (author), Achakri, Hassan (author), Benazzo, Francesco (author), Günther, Klaus-Peter (author)

review 2023

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3D printed patient-specific fixation plates for the treatment of slipped capital femoral epiphysis: Topology optimization vs. conventional design

Moosabeiki, Vahid (author), de Winter, N. (author), Cruz Saldivar, M. (author), Leeflang, M.A. (author), Witbreuk, M. M.E.H. (author), Lagerburg, V. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)

Orthopedic plates are commonly used after osteotomies for temporary fixation of bones. Patient-specific plates have recently emerged as a promising fixation device. However, it is unclear how various strategies used for the design of such plates perform in comparison with each other. Here, we compare the biomechanical performance of 3D...

journal article 2023

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Production of Co-58m in a siphon-style liquid target on a medical cyclotron

Mues genannt Koers, L. (author), McNeil, S. W. (author), Radchenko, V. (author), Paulssen, E. (author), Hoehr, C. (author)

We present the production of ^58mCo on a small, 13 MeV medical cyclotron utilizing a siphon style liquid target system. Different concentrated iron(III)-nitrate solutions of natural isotopic distribution were irradiated at varying initial pressures and subsequently separated by solid phase extraction chromatography. The radio cobalt...

journal article 2023

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NLICE: Synthetic Medical Record Generation for Effective Primary Healthcare Differential Diagnosis

Al-Ars, Z. (author), Agba, Obinna (author), Guo, Zhuoran (author), Boerkamp, C. (author), Jaber, Ziyaad (author), Jaber, Tareq (author)

This paper offers a systematic method for creating medical knowledge-grounded patient records for use in activities involving differential diagnosis. Additionally, an assessment of machine learning models that can differentiate between various conditions based on given symptoms is also provided. We use a public disease-symptom data source called...

conference paper 2023

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Predictors of Persistent Somatic Symptoms in the General Population: A Systematic Review of Cohort Studies

Kitselaar, Willeke M. (author), Van Der Vaart, Rosalie (author), Perschl, Johanna (author), Numans, M.E. (author), Evers, A.W.M. (author)

Objective Up to 10% of the general population experiences persistent somatic symptoms (PSS). Numerous studies in a variety of health domains are dedicated to identifying factors that are associated with PSS onset. The present study aimed to provide an overview of predictors for PSS onset in the general population and the related health...

journal article 2023

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Why we should not mistake accuracy of medical AI for efficiency

Jongsma, K.R. (author), Sand, M. (author), Milota, Megan (author)

In the medical literature, promising results regarding accuracy of medical AI are presented as claims for its potential to increase efficiency. This elision of concepts is misleading and incorrect. First, the promise that AI will reduce human workload rests on a too narrow assessment of what constitutes workload in the first place. Human...

journal article 2023

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Bioinspired medical needles: a review of the scientific literature

Fung-A-Jou, Zola (author), Bloemberg, J. (author), Breedveld, P. (author)

Needles are commonly used in medical procedures. However, current needle designs have some disadvantages. Therefore, a new generation of hypodermic needles and microneedle patches drawing inspiration from mechanisms found in nature (i.e. bioinspiration) is being developed. In this systematic review, 80 articles were retrieved from Scopus, Web...

journal article 2023

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Field Model Identification and Control of a Mobile Electromagnet for Remote Actuation of Soft Robots

Riccardi, A. (author), Furtado, Guilherme P. (author), Sikorski, Jakub (author), Vendittelli, Marilena (author), Misra, Sarthak (author)

The actuation of miniaturized robots through external magnetic fields has great potential for medical applications. The controllability properties of the miniaturized robots are affected by magnetic field generation modality. In this work, the magnetic field of a mobile electromagnet, notably capable to generate a desired magnetic field in...

journal article 2023

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Autonomous Navigation for Robot-Assisted Intraluminal and Endovascular Procedures: A Systematic Review

Pore, Ameya (author), Li, Z. (author), Dall'Alba, Diego (author), Hernansanz, Albert (author), De Momi, Elena (author), Menciassi, Arianna (author), Casals Gelpi, Alicia (author), Dankelman, J. (author), Fiorini, Paolo (author), Poorten, Emmanuel Vander (author)

Increased demand for less invasive procedures has accelerated the adoption of Intraluminal Procedures (IP) and Endovascular Interventions (EI) performed through body lumens and vessels. As navigation through lumens and vessels is quite complex, interest grows to establish autonomous navigation techniques for IP and EI for reaching the target...

journal article 2023

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Reinforcement Learning for Intelligent Healthcare Systems: A Review of Challenges, Applications, and Open Research Issues

Abdellatif, Alaa Awad (author), Mhaisen, N. (author), Mohamed, Amr (author), Erbad, Aiman (author), Guizani, Mohsen (author)

The rise of chronic disease patients and the pandemic pose immediate threats to healthcare expenditure and mortality rates. This calls for transforming healthcare systems away from one-on-one patient treatment into intelligent health systems, leveraging the recent advances of Internet of Things and smart sensors. Meanwhile, reinforcement...

journal article 2023

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Repetitive Control for Lur'e-Type Systems: Application to Mechanical Ventilation

Reinders, Joey (author), Giaccagli, Mattia (author), Hunnekens, Bram (author), Astolfi, Daniele (author), Oomen, T.A.E. (author), Van De Wouw, Nathan (author)

Repetitive control (RC) has shown to achieve superior rejection of periodic disturbances. Many nonlinear systems are subject to repeating disturbances. The aim of this article is to develop a continuous-time RC design with stability guarantees for nonlinear Lur'e-type systems. Approximate output tracking is achieved by combining an internal...

journal article 2023

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Density reduction effects on the production of [11C]CO2 in Nb-body targets on a medical cyclotron

Mues genannt Koers, Lucas (author), Prevost, David (author), Paulssen, E. (author), Hoehr, Cornelia (author)

Medical isotope production of ¹¹C is commonly performed in gaseous targets. The power deposition of the proton beam during the irradiation decreases the target density due to thermodynamic mixing and can cause an increase of penetration depth and divergence of the proton beam. In order to investigate the difference how the target...

journal article 2023

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EQRSRL: an energy-aware and QoS-based routing schema using reinforcement learning in IoMT

Nazari, Amin (author), Kordabadi, Mojtaba (author), Mohammadi, R. (author), Lal, C. (author)

Internet of Medical Thing (IoMT) is an emerging technology in healthcare that can be used to realize a wide variety of medical applications. It improves people’s quality of life and makes it easier to care for the sick individuals in an efficient and safe manner. To do this, IoMT leverages the capabilities of some new technologies including...

journal article 2023