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Large-scale sandpits: Hydrodynamic and morfological modelling of large-scale sandpits

Klein, M.D. (author)

report 1999

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Large-scale sandpits - Hydrodynamic and morphological modelling of large-scale sandpits

Klein, M.D. (author)

Large-scale, marine sand mining in front ofthe Dutch coast might be necessary in the near future in order to meet the needs of sand for regular engineering works and/or for a possible second Maasvlakte or a national airport on an artificial island. In order to make a socio-economically and environmentally sound decision with respect to location...

master thesis 1999

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Modelling rhythmic morphology in the surf zone

Klein, M.D. (author)

Coastal erosion is increasingly being prevented by the application of shoreface nourishments. Although they are applied successfully, their development and their impact on the coastal system is still difficult to predict. Especially the effects of shoreface nourishments on the already existing rhythmic bed forms in the surf zone are unknown. The...

doctoral thesis 2006

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Modeling the brain morphology distribution in the general aging population

Huizinga, W. (author), Poot, D.H.J. (author), Roshchupkin, G. (author), Bron, E. E. (author), Ikram, M. A. (author), Vernooij, M. W. (author), Rueckert, D. (author), Niessen, W.J. (author), Klein, S. (author)

Both normal aging and neurodegenerative diseases such as Alzheimer's disease cause morphological changes of the brain. To better distinguish between normal and abnormal cases, it is necessary to model changes in brain morphology owing to normal aging. To this end, we developed a method for analyzing and visualizing these changes for the...

conference paper 2016

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Why Argonaute is needed to make microRNA target search fast and reliable

Klein, M. (author), Chandradoss, S.D. (author), Depken, S.M. (author), Joo, C. (author)

MicroRNA (miRNA) interferes with the translation of cognate messenger RNA (mRNA) by finding, preferentially binding, and marking it for degradation. To facilitate the search process, Argonaute (Ago) proteins come together with miRNA, forming a dynamic search complex. In this review we use the language of free-energy landscapes to discuss...

journal article 2017

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Policy Emergence: An agent-based approach

Klein, R. (author)

master thesis 2017

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Dynamic contrast-enhanced MRI of the patellar bone: How to quantify perfusion

Poot, D.H.J. (author), van der Heijden, R.A.J. (author), van Middelkoop, Marienke (author), Oei, Edwin H.G. (author), Klein, S. (author)

Purpose: To identify the optimal combination of pharmacokinetic model and arterial input function (AIF) for quantitative analysis of blood perfusion in the patellar bone using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Materials and Methods: This method design study used a random subset of five control subjects from an...

journal article 2018

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Circular Business Models: Building a Database of Case Studie

Vergara d'Alençon, L.M. (author), Arkesteijn, M.H. (author), Azcarate Aguerre, J.F. (author), den Heijer, A.C. (author), Klein, T. (author)

report 2019

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Disease progression timeline estimation for Alzheimer's disease using discriminative event based modeling

Venkatraghavan, Vikram (author), Bron, Esther E. (author), Niessen, W.J. (author), Klein, S. (author)

Alzheimer's Disease (AD) is characterized by a cascade of biomarkers becoming abnormal, the pathophysiology of which is very complex and largely unknown. Event-based modeling (EBM) is a data-driven technique to estimate the sequence in which biomarkers for a disease become abnormal based on cross-sectional data. It can help in understanding...

journal article 2019

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Natural gas displacement by wind curtailment utilization in combined-cycle power plants

Gangoli Rao, A. (author), van den Oudenalder, F. S.C. (author), Klein, S.A. (author)

The energy scenario is currently undergoing a rapid transition in the pursuit of increasing the share of renewable energy sources in order to reduce the global anthropogenic CO2 emission. However, since several of the renewable energy sources are intermittent in nature, like wind and solar, this intermittency gives rise to several problems in...

journal article 2019

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Analyzing the effect of APOE on Alzheimer's disease progression using an event-based model for stratified populations

Venkatraghavan, Vikram (author), Klein, S. (author), Fani, Lana (author), Ham, Leontine S. (author), Vrooman, Henri (author), Ikram, M. Kamran (author), Niessen, W.J. (author), Bron, Esther E. (author)

Alzheimer's disease (AD) is the most common form of dementia and is phenotypically heterogeneous. APOE is a triallelic gene which correlates with phenotypic heterogeneity in AD. In this work, we determined the effect of APOE alleles on the disease progression timeline of AD using a discriminative event-based model (DEBM). Since DEBM is a data...

journal article 2020

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A modelling based study on the integration of 10 MW_th indirect torrefied biomass gasification, methanol and power production

Del Grosso, M. (author), Sridharan, Balaji (author), Tsekos, C. (author), Klein, S.A. (author), de Jong, W. (author)

This work is focused on the process system modelling of an indirectly heated gasifier (10 MW_th) using torrefied wood as feedstock and its integration with methanol and power production using Aspen Plus®. The modelling of the gasification process along with the obtained reaction kinetics were validated with experimental data found...

journal article 2020

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Progression along data-driven disease timelines is predictive of Alzheimer's disease in a population-based cohort

Venkatraghavan, Vikram (author), Vinke, Elisabeth J. (author), Bron, Esther E. (author), Niessen, W.J. (author), Arfan Ikram, M. (author), Klein, S. (author), Vernooij, Meike W. (author)

Data-driven disease progression models have provided important insight into the timeline of brain changes in AD phenotypes. However, their utility in predicting the progression of pre-symptomatic AD in a population-based setting has not yet been investigated. In this study, we investigated if the disease timelines constructed in a case...

journal article 2021

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Differences Between MR Brain Region Segmentation Methods: Impact on Single-Subject Analysis

Huizinga, W. (author), Poot, D.H.J. (author), Vinke, E. J. (author), Wenzel, F. (author), Bron, E. E. (author), Ikram, M. A. (author), Niessen, W.J. (author), Vernooij, M.N.A. (author), Klein, S. (author)

For the segmentation of magnetic resonance brain images into anatomical regions, numerous fully automated methods have been proposed and compared to reference segmentations obtained manually. However, systematic differences might exist between the resulting segmentations, depending on the segmentation method and underlying brain atlas. This...

journal article 2021

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A Computational Network Model for Shared Mental Models in Hospital Operation Rooms

van Ments, Laila (author), Treur, J. (author), Klein, L.J. (author), Roelofsma, P.H.M.P. (author)

This paper describes a network model for mental processes making use of shared mental models (SMM) of team performance. The paper illustrates the value of adequate SMM’s for safe and efficient team performance. The addressed application context is that of a medical team performing a tracheal intubation executed by a nurse and a medical...

conference paper 2021

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Financial Stock Market Modeling and the COVID-19 crisis: Has COVID-19 structurally changed the dynamics of the stock market?

Klein, Isabel (author)

The COVID-19 crisis heavily affected financial stock markets. In March 2020 stock prices dropped immensely and markets became extremely volatile. In this report we model three European stock markets before and during the COVID-19 crisis to determine whether the dynamics of financial markets changed structurally compared to previous periods....

bachelor thesis 2021

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Building energy retrofit-as-a-service: a Total Value of Ownership assessment methodology to support whole life-cycle building circularity and decarbonisation: Construction Management and Economics

Azcarate Aguerre, J.F. (author), Conci, Mira (author), Zils, Markus (author), Hopkinson, Peter (author), Klein, T. (author)

The regulatory drive to accelerate the clean energy and circular economy transitions in the European building stock is currently failing to overcome systemic implementation barriers. These barriers include high initial investment costs, misaligned financial incentives among stakeholders, and the relatively low cost of less sustainable energy and...

journal article 2022

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Developing a framework to improve the collaboration in the first phase of the two-phase model: A study on the collaboration between the contractor and client and the contribution of a collaborative identity

Klein, Simon (author)

A trend towards a more relational type of contracting can be noticed in the Dutch infrastructure industry. These so-called relational project delivery models are supposed to deal with the current challenges of regular cost and time overruns, the growing demand and the adverse relationship between contractor and client in traditional projects,...

master thesis 2022

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Structure-Preserving Hyper-Reduction Methods for the Incompressible Navier-Stokes Equations

Klein, Robin (author)

In this master thesis several novel DEIM formulations are proposed that enable the construction of non-linearly stable hyper-reduced order models (hROMs) of the incompressible Navier-Stokes equations. The hROMs have the same mass, momentum and energy conservation properties as the previously proposed ROM, but they do not suffer of prohibitively...

master thesis 2022

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L'Internet of Things per la transizione circolare nel settore delle facciate

Giovanardi, Matteo (author), Konstantinou, T. (author), Pollo, Riccardo (author), Klein, T. (author)

In the façade sector, the ecological and circular transition requires the adoption of new business models that exploit the value of the material as much as possible. In this context, the Internet of Things (IoT) is identified as a potential innovation driver for the widespread use of circular approaches. The aim of the paper is to clarify the...

journal article 2023