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van der Kruk, E. (author), Geijtenbeek, T. (author)The ‘Timed Up and Go’ test (TUG) is a widely used clinical tool for assessing gait and balance, relying primarily on timing as a measure. However, there are more observable biomechanical compensation strategies within TUG that are indicative of underlying neuromuscular issues and movement priorities. In individuals with unilateral knee...journal article 2024
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Yuan, T. (author)The thumb finger is indispensable for an independent daily life. Implant replacement, which aims to restore joint mobility and functionality, is one of the surgical treatments for patients with osteoarthritis at the thumb-base. However, current designs and the biomechanical understanding of the thumb-base joint are inadequate. Small bone size,...doctoral thesis 2023
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Heijs, Floor (author)Background: Knee Osteoarthritis (KOA) is the predominant form of osteoarthritis, and its incidence is anticipated to rise due to an ageing and increasingly overweight population. Altering the Foot Progression Angle (FPA) has demonstrated potential in mitigating the progression of KOA. Wearable feedback methods, especially those utilising single...master thesis 2023
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de Jong, Julia (author)Ankle osteoarthritis (AOA) or degenerative joint disease (DJD ) of the ankle, is a progressive condition characteristic by the thinning of cartilage between the tibia and talus bone. Eventually, this leads to complete ankle joint loss. When looking at surgical treatments, joint sacrificing treatments are the golden standard. Young active people...master thesis 2023
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- van Duijnhoven, Hugo (author) master thesis 2023
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Fugazzola, Maria C. (author), Golafshan, Nasim (author), van Aken, Joris A. (author), Plomp, S. (author), De Grauw, Janny (author), van Buul, Ward (author), Hermsen, Gied (author), Weinans, Harrie (author), Castilho, Miguel (author), van Weeren, René (author), Malda, Jos (author)Summary: The objective of this study was to evaluate a non-resorbable implant for the focal repair of osteochondral defects. Enhanced adherence of repair cartilage overgrowing the implants was the secondary goal and was tested by introducing porosities on the articular surface of the implant. This study evaluated four versions of the...journal article 2023
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Eijkenboom, J. F.A. (author), Tümer, N. (author), Schiphof, D. (author), Oei, E. H. (author), Zadpoor, A.A. (author), Bierma-Zeinstra, S. M.A. (author), van Middelkoop, M. (author)Objective: To examine the association between 3D patellar shape and 1) isolated magnetic resonance imaging (MRI)-based patellofemoral osteoarthritis (PFOA), 2) the morphological features of PFOA, and 3) the clinical symptoms of PFOA. Design: MRI data from 66 women with isolated MRI-based PFOA and 66 age- and BMI-matched healthy women were...journal article 2023
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Arbabi, Saeed (author), Foppen, Wouter (author), Gielis, Willem Paul (author), van Stralen, Marijn (author), Jansen, Mylène (author), Arbabi, Vahid (author), de Jong, Pim A. (author), Weinans, Harrie (author), Seevinck, Peter (author)Magnetic resonance Imaging is the gold standard for assessment of soft tissues; however, X-ray-based techniques are required for evaluating bone-related pathologies. This study evaluated the performance of synthetic computed tomography (sCT), a novel MRI-based bone visualization technique, compared with CT, for the scoring of knee...journal article 2023
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Warmink, Kelly (author), Vinod, Prateeksha (author), Korthagen, Nicoline M. (author), Weinans, Harrie (author), Rios, Jaqueline L. (author)Osteoarthritis (OA) is a common and debilitating joint disorder that leads to progressive joint breakdown and loss of articular cartilage. Accompanied by a state of low-grade inflammation, its etiology extends beyond that of a wear-and-tear disease, and the immune system might have a role in its initiation and progression. Obesity, which is...review 2023
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- Velot, Émilie (author), Balmayor, Elizabeth R. (author), Bertoni, Lélia (author), Chubinskaya, Susan (author), Cicuttini, Flavia (author), de Girolamo, Laura (author), Demoor, Magali (author), van Osch, G.J.V.M. (author), Cucchiarini, Magali (author) review 2023
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Rayegan, H. (author), Nguyen, H. C. (author), Weinans, Harrie (author), Gielis, W. P. (author), Ahmadi Brooghani, S. Y. (author), Custers, R. J.H. (author), van Egmond, N. (author), Lindner, C. (author), Arbabi, V. (author)Objective: Herewith, we report the development of Orthopedic Digital Image Analysis (ODIA) software that is developed to obtain quantitative measurements of knee osteoarthritis (OA) radiographs automatically. Manual segmentation and measurement of OA parameters currently hamper large-cohort analyses, and therefore, automated and reproducible...journal article 2023
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Warmink, K. (author), Rios, J. L. (author), van Valkengoed, D. R. (author), Vinod, P. (author), Korthagen, N. M. (author), Weinans, Harrie (author)Introduction: Obesogenic diets aggravate osteoarthritis (OA) by inducing low-grade systemic inflammation, and diet composition may affect OA severity. Here, we investigated the effect of diet on joint damage and inflammation in an OA rat model. Methods: Wistar-Han rats (n = 24) were fed a chow, a high-fat (HF) diet, or a high-fat/high-sucrose...journal article 2023
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Warmink, Kelly (author), Rios, Jaqueline L. (author), Varderidou-Minasian, Suzy (author), Torres-Torrillas, Marta (author), van Valkengoed, Devin R. (author), Versteeg, Sabine (author), Eijkelkamp, Niels (author), Weinans, Harrie (author), Korthagen, Nicoline M. (author), Lorenowicz, Magdalena J. (author)Background: Mesenchymal stromal/stem cells (MSCs) and MSC-derived extracellular vesicles (MSC-EVs) hold promise as a disease modifying treatment in osteoarthritis (OA). Obesity, and its associated inflammation, contribute to OA development and metabolic OA represents a specific and significant group of the OA patient population. Given their...journal article 2023
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Wildöer, David (author)To better understand and predict osteoarthritis, researchers are developing so-called coupled modelling workflows. Coupled workflows convert data from gait analysis studies to subject-specific tissue mechanical response estimations through the use of musculoskeletal and finite element models. The tissue mechanical response inside the joint is...master thesis 2022
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Gevers, Imke (author)Background: Radiostereometric analysis (RSA) is a technique to assess early migration, which has a predictive value for early failure of unicompartmental knee arthroplasty (UKA). To successfully analyze the RSA images it is important to have a sufficient amount of visiblemarkers with an acceptable three-dimensional distribution.<br/>Objective:...master thesis 2022
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Schijf, Menno (author)Introduction - Arthritis is a condition causing pain, deformations and loss of motion in human joints. The surgical instruments used to place a specific unconstrained prosthesis that is used to treat an arthritic joint are difficult to use. The objective for this thesis is to improve the current placement procedure by carrying out an analysis on...master thesis 2022
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Satam, Anuja P. (author), van der Leeden, Marike (author), de Zwart, Arjan (author), Verberne, Simon (author), Schrijvers, Jim C. (author), Hall, Michelle (author), Dekker, Joost (author), Lems, Willem F. (author), Harlaar, J. (author), van der Esch, Martin (author)Background: Muscle weakness is characteristic of knee osteoarthritis. Muscle steadiness may be an important adjunct to knee muscle strength in improving physical function in knee osteoarthritis. However, the role of muscle steadiness is uncertain. Aims: To determine the associations of knee extensor muscle steadiness with maximal voluntary...journal article 2022
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Harlaar, J. (author), Macri, E.M. (author), Wesseling, M.G.H. (author)Osteoarthritis (OA) has a complex, heterogeneous and only partly understood etiology. There is a definite role of joint cartilage pathomechanics in originating and progressing of the disease. Although it is still not identified precisely enough to design or select targeted treatments, the progress of this year's research demonstrates that...review 2022
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Waterval, N.F.J. (author), Brehm, M. A. (author), Harlaar, J. (author), Nollet, F. (author)Background: In individuals with unilateral plantar flexor weakness, the second peak of the vertical ground reaction force (GRF) is decreased. This leads to a higher ground reaction force, e.g. impact, of the contralateral leg, potentially explaining quadriceps muscle and/or knee joint pain. Energy cost optimized dorsal leaf ankle-foot...journal article 2022
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An integrated in silico-in vitro approach for identifying therapeutic targets against osteoarthritisLesage, Raphaëlle (author), Ferrao Blanco, Mauricio N. (author), Narcisi, Roberto (author), Welting, Tim (author), van Osch, G.J.V.M. (author), Geris, Liesbet (author)Background: Without the availability of disease-modifying drugs, there is an unmet therapeutic need for osteoarthritic patients. During osteoarthritis, the homeostasis of articular chondrocytes is dysregulated and a phenotypical transition called hypertrophy occurs, leading to cartilage degeneration. Targeting this phenotypic transition has...journal article 2022