PTV-based VMAT vs. robust IMPT for head-and-neck cancer: A probabilistic uncertainty analysis of clinical plan evaluation with the Dutch model-based selection

Background and purpose: In the Netherlands, head-and-neck cancer (HNC) patients are referred for proton therapy (PT) through model-based selection (MBS). However, treatment errors may compromise adequate CTV dose. Our aims are: (i) to derive probabilistic plan evaluation metrics on the CTV consistent with clinical metrics; (ii) to evaluate...

Offshore infrastructure planning using a vine copula approach for environmental conditions: an application for replacement maintenance of tidal energy infrastructure

Installation and maintenance operations of offshore assets are impacted by local environmental conditions such as wave height and period, wind speed and current velocity. These parameters are substantially of influence for the asset planning (time and costs) given the uncertainty of operational windows. In this article, a method is proposed to...