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Arifvianto, B. (author), Zhou, J. (author)Bone tissue engineering has been increasingly studied as an alternative approach to bone defect reconstruction. In this approach, new bone cells are stimulated to grow and heal the defect with the aid of a scaffold that serves as a medium for bone cell formation and growth. Scaffolds made of metallic materials have preferably been chosen for...journal article 2014
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Van der Stok, J. (author), Koolen, M.K.E. (author), De Maat, M.P.M. (author), Amin Yavari, S. (author), Alblas, J. (author), Patka, P. (author), Verhaar, J.A.N. (author), Van Lieshout, E.E.M. (author), Zadpoor, A.A. (author), Weinans, H.H. (author), Jahr, H. (author)Regeneration of load-bearing segmental bone defects is a major challenge in trauma and orthopaedic surgery. The ideal bone graft substitute is a biomaterial that provides immediate mechanical stability, while stimulating bone regeneration to completely bridge defects over a short period. Therefore, selective laser melted porous titanium,...journal article 2015
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Alexandrescu, Maria (author), Forgaci, C. (author), Ionescu, Ioana (author)Landscape architecture, landscape urbanism, and urbanism provide a number of tools, methods, and techniques for the design of the built and unbuilt urban landscape. The interplay of these techniques is left up to the designers, and the resulting range of projects associated with the terms is broad and inconsistent. This paper proposes Urban...conference paper 2016
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Li, Y. (author), Zhou, J. (author), Pavanram, P. (author), Leeflang, M.A. (author), Fockaert, L.I. (author), Pouran, B. (author), Tümer, N. (author), Schröder, K. U. (author), Mol, J.M.C. (author), Weinans, Harrie (author), Jahr, H. (author), Zadpoor, A.A. (author)An ideal bone substituting material should be bone-mimicking in terms of mechanical properties, present a precisely controlled and fully interconnected porous structure, and degrade in the human body to allow for full regeneration of large bony defects. However, simultaneously satisfying all these three requirements has so far been highly...journal article 2017
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Zhang, X.Y. (author), Fang, G (author), Zhou, J. (author)Additive manufacturing (AM), nowadays commonly known as 3D printing, is a revolutionary materials processing technology, particularly suitable for the production of low-volume parts with high shape complexities and often with multiple functions. As such, it holds great promise for the fabrication of patient-specific implants. In recent years,...journal article 2017
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Ye, Xiaotong (author), Leeflang, M.A. (author), Wu, Chengtie (author), Chang, Jiang (author), Zhou, J. (author), Huan, Z. (author)Porous Ti-6Al-4V scaffolds fabricated by means of selective laser melting (SLM),<br/>having controllable geometrical features and preferable mechanical properties, have been developed as a class of biomaterials that hold promising potential for bone repair. However, the inherent bio-inertness of the Ti-6Al-4V alloy as the matrix of the scaffolds...journal article 2017
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Hedayati, R. (author), Amin Yavari, S. (author), Zadpoor, A.A. (author)Additively manufactured porous titanium implants, in addition to preserving the excellent biocompatible properties of titanium, have very small stiffness values comparable to those of natural bones. Although usually loaded in compression, biomedical implants can also be under tensional, shear, and bending loads which leads to crack initiation...journal article 2017
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Arifvianto, B. (author)Loss of function and impaired life quality as a result of large bone defects remain a serious problem in the society. Basically, the bone tissue has the capability of healing by itself when fractured. However, impaired healing may occur, leading to delayed union or even non-union when a bone segment is excised above a critical size. In recent...doctoral thesis 2017
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Li, Y. (author), Jahr, H. (author), Lietaert, K. (author), Pavanram, P. (author), Yilmaz, A. (author), Fockaert, L.I. (author), Leeflang, M.A. (author), Pouran, B. (author), Gonzalez Garcia, Y. (author), Weinans, Harrie (author), Mol, J.M.C. (author), Zhou, J. (author), Zadpoor, A.A. (author)Additively manufactured (AM) topologically ordered porous metallic biomaterials with the proper biodegradation profile offer a unique combination of properties ideal for bone regeneration. These include a fully interconnected porous structure, bone-mimicking mechanical properties, and the possibility of fully regenerating bony defects. Most...journal article 2018
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Zhang, Xiang Yu (author), Fang, Gang (author), Xing, Lei Lei (author), Liu, Wei (author), Zhou, J. (author)Functionally graded scaffold (FGS) is designed to mimic the morphology, mechanical and biological properties of natural bone closely. Porosity variation strategy between different regions in FGS plays a crucial role in influencing its mechanical and biological performance. A combination of modeling tool and scripting language can effectively...journal article 2018
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De Witte, Tinke (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author), Peppas, Nicholas (author)In recent years, bone tissue engineering has emerged as a promising solution to the limitations of current gold standard treatment options for bone related-disorders such as bone grafts. Bone tissue engineering provides a scaffold design that mimics the extracellular matrix, providing an architecture that guides the natural bone regeneration...journal article 2018
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Li, Y. (author), Lietaert, K. (author), Li, W. (author), Zhang, X.Y. (author), Leeflang, M.A. (author), Zhou, J. (author), Zadpoor, A.A. (author)The corrosion fatigue behavior of additively manufactured topologically ordered porous iron based on diamond unit cells was studied for the first time to understand its response to cyclic loading in a simulated physiological environment. The material exhibited high fatigue resistance with fatigue strengths being 70% and 65% of yield stress in...journal article 2019
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Frey, Marion (author), Zirkelbach, Meri (author), Dransfeld, C.A. (author), Faude, Eric (author), Trachsel, Etienne (author), Hannus, Mikael (author), Burgert, Ingo (author), Keplinger, Tobias (author)Delignified densified wood is a new promising and sustainable material that possesses the potential to replace synthetic materials, such as glass fiber reinforced composites, due to its excellent mechanical properties. Delignified wood, however, is rather fragile in a wet state, which makes handling and shaping challenging. Here we present...journal article 2019
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Li, Y. (author), Jahr, H. (author), Zhou, J. (author), Zadpoor, A.A. (author)Partially due to the unavailability of ideal bone substitutes, the treatment of large bony defects remains one of the most important challenges of orthopedic surgery. Additively manufactured (AM) biodegradable porous metals that have emerged since 2018 provide unprecedented opportunities for fulfilling the requirements of an ideal bone...review 2020
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De Witte, Tinke Marie (author), Wagner, Angela M. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author), Peppas, Nicholas A. (author)To guide the natural bone regeneration process, bone tissue engineering strategies rely on the development of a scaffold architecture that mimics the extracellular matrix and incorporates important extracellular signaling molecules, which promote fracture healing and bone formation pathways. Incorporation of growth factors into particles...journal article 2020
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Li, Y. (author), Pavanram, P. (author), Zhou, J. (author), Lietaert, K. (author), Taheri, P. (author), Li, W. (author), San, H. (author), Leeflang, M.A. (author), Mol, J.M.C. (author), Jahr, H. (author), Zadpoor, A.A. (author)Additively manufacturing (AM) opens up the possibility for biodegradable metals to possess uniquely combined characteristics that are desired for bone substitution, including bone-mimicking mechanical properties, topologically ordered porous structure, pore interconnectivity and biodegradability. Zinc is considered to be one of the promising...journal article 2020
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Dong, J. (author), Li, Y. (author), Lin, P. (author), Leeflang, M.A. (author), van Asperen, S. (author), Yu, K. (author), Tümer, N. (author), Norder, B. (author), Zadpoor, A.A. (author), Zhou, J. (author)Biodegradable porous magnesium (Mg) scaffolds are promising for application in the regeneration of critical-sized bone defects. Although additive manufacturing (AM) carries the promise of offering unique opportunities to fabricate porous Mg scaffolds, current attempts to apply the AM approach to fabricating Mg scaffolds have encountered some...journal article 2020
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Schouten, D.G.M. (author), Massink, Pim (author), Donker, Stella F. (author), Neerincx, M.A. (author)In this study, we attempt to specify the cognitive support behavior of a previously designed embodied conversational agent coach that provides learning support to low-literates. Three knowledge gaps are identified in the existing work: an incomplete specification of the behaviors that make up ‘support,’ an incomplete specification of how this...journal article 2020
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Zhou, Liangbin (author), van Osch, G.J.V.M. (author), Malda, Jos (author), Stoddart, Martin J. (author), Lai, Yuxiao (author), Richards, R. Geoff (author), Ki-wai Ho, Kevin (author), Qin, Ling (author)Clinical treatments for the repair of osteochondral defects (OCD) are merely palliative, not completely curative, and thus enormously unfulfilled challenges. With the in-depth studies of biology, medicine, materials, and engineering technology, the conception of OCD repair and regeneration should be renewed. During the past decades, many...review 2020
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Li, Y. (author)For the treatment of large bony defects, no perfect solution has been yet found, partially due to the unavailability of ideal bone implants. Additively manufactured (AM) biodegradable porous metals provide unprecedented opportunities to fulfil the requirements for ideal bone implants to be used in such treatments. Firstly, the multi-scale...doctoral thesis 2020
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