A novel viral infection model to guide optimal mpox treatment

In 2022, worldwide mpox outbreaks have called attention to mpox virus infection and treatment opportunities using the drugs cidofovir and tecovirimat, which target different stages of in-host viral proliferation, respectively production and shedding. We propose a new model of in-host viral infection dynamics that distinguishes between the two...

An efficient transient-state algorithm for evaluation of leakage through defective cutoff walls

Artificial barriers are widely used to prevent leakages. However, due to construction errors during the wall installation, passages with small dimensions may occasionally penetrate through the barrier, undermining its tightness. A three-dimensional discretized algorithm (TDA) is proposed for quantitatively estimating the transient-state...