Searched for: subject%3A%22stem%255C+cell%22
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Velot, Émilie (author), Balmayor, Elizabeth R. (author), Bertoni, Lélia (author), Chubinskaya, Susan (author), Cicuttini, Flavia (author), de Girolamo, Laura (author), Demoor, Magali (author), van Osch, G.J.V.M. (author), Cucchiarini, Magali (author)
review 2023
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Tjernshaugen, Aurora (author)
That mechanical properties of the extracellular environment can influence cell behaviour has already been established. Recent studies indicate that human mesenchymal stem cells are affected by the surface curvature of the underlying substrate. However, how meso-scale substrate curvature affects cell behaviour is still not clear. This study...
master thesis 2022
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Berenger-Currias, N.M.L.P. (author)
Embryogenesis is a fascinating mystery. How a single fertilized egg, the zygote, reads out its genetic information and turns into a fully formed, multicellular organism still defies detailed understanding. <br/>An adult organism can consist of trillions of cells of different types, organized to form various complex tissues and organs. To obtain...
doctoral thesis 2022
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Melsen, Janine E. (author), van Ostaijen-ten Dam, Monique M. (author), van den Akker, E.B. (author), Welters, Marij J.P. (author), Heezen, Kim C. (author), Pico-Knijnenburg, Ingrid (author), Kolijn, P.M. (author), Bredius, Robbert G.M. (author), van Doorn, Remco (author)
The first successful European hematopoietic stem cell transplantation (HSCT) was performed in 1968 as treatment in a newborn with IL2RG deficiency using an HLA-identical sibling donor. Because of declining naive T and natural killer (NK) cells, and persistent human papilloma virus (HPV)-induced warts, the patient received a peripheral stem...
journal article 2022
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Berenger-Currias, N.M.L.P. (author), Mircea, Maria (author), Adegeest, Esmée (author), van den Berg, Patrick R. (author), Feliksik, Marleen (author), Hochane, Mazène (author), Idema, T. (author), Tans, S.J. (author), Semrau, Stefan (author)
Stem-cell derived in vitro systems, such as organoids or embryoids, hold great potential for modeling in vivo development. Full control over their initial composition, scalability, and easily measurable dynamics make those systems useful for studying specific developmental processes in isolation. Here we report the formation of gastruloids...
journal article 2022
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Neves Leal Costa, B. (author), Adão, Ricardo M.R. (author), Maibohm, Christian (author), Accardo, A. (author), Cardoso, Vanessa F. (author), Nieder, Jana B. (author)
Biomimicking biological niches of healthy tissues or tumors can be achieved by means of artificial microenvironments, where structural and mechanical properties are crucial parameters to promote tissue formation and recreate natural conditions. In this work, three-dimensional (3D) scaffolds based on woodpile structures were fabricated by two...
journal article 2022
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Castillo Ransanz, Lucía (author), van Altena, P.F.J. (author), Heine, Vivi M. (author), Accardo, A. (author)
The biomechanical properties of the brain microenvironment, which is composed of different neural cell types, the extracellular matrix, and blood vessels, are critical for normal brain development and neural functioning. Stiffness, viscoelasticity and spatial organization of brain tissue modulate proliferation, migration, differentiation, and...
review 2022
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Daneshpour Aryadi, H. (author)
Tales of a Fountain of Youth and the invention of medicine illustrate our age-long obsession with two themes: life and death. What it takes to stay alive, and not to be dead, is a basic question in science that is easy to state, and yet difficult to address at a profound level. One striking feature of many living organisms is the ability of...
doctoral thesis 2021
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Wagenaar, Kirsten (author)
To this day, liver transplantation is the only effective treatment for end-stage liver failure. Unfortunately, the scarcity of liver donors leads to waitlist mortality, pushing the need for alternative treatment options. In vitro models are essential tools in research on alternatives for transplantation. One of the promising models is the...
master thesis 2021
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Garmendia Urdalleta, Amaia (author)
Background: Despite the considerable development of the field of orthopedic implants in the past century, complications including poor bone ingrowth and implant associated infection (IAI) persist to this day, causing a huge burden to millions of patients and the healthcare systems worldwide. Additive manufacturing (AM) and the subsequent surface...
master thesis 2021
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Berkhout, Willemijn (author)
Three-dimensional (3D) bioprinting studies the initial condition of printed constructs, which makes construct static, and neglects the dynamic changes in natural tissue conformation during tissue repair, disease progression and regeneration processes. Therefore, the concept of four-dimensional (4D) bioprinting has been introduced that allows for...
master thesis 2021
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Mastrangeli, Massimo (author), van den Eijnden-van Raaij, A.J.M. (author)
Organ-on-chip (OoC) technology is thriving thanks to stem cells availability and international OoC programs. Concerted standardization, qualification, and independent testing of devices are needed to coherently develop OoC technology further and fulfill its potential in drug development, disease modeling, and personalized medicine. The OoC...
journal article 2021
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Dostanic, M. (author), Stein, Jeroen (author), Windt, Laura (author), van Meer, Berend (author), Bellin, Milena (author), Orlova, Valeria (author), Mastrangeli, Massimo (author), Mummery, Christine (author), Sarro, Pasqualina M (author)
We present a wafer-scale fabricated, PDMS-based platform for culturing miniaturized engineered heart tissues (EHTs) which allows highly accurate measurements of the contractile properties of these tissues. The design of the platform is an anisometrically downscaled version of the Heart-Dyno system, consisting of two elastic micropillars inside...
journal article 2020
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Sfakianou, Areti (author)
Psychiatric disorders are associated with major societal, personal issues and comprise 13% of the global burden of disease. They are heritable and present a complex pathophysiology, characterized by hundreds of genetic variants which are cumulated together and provoke a specific psychiatric disorder. Although a considerable progress has been...
master thesis 2019
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Mastrangeli, Massimo (author), Millet, Sylvie (author), ORCHID partners, the (author), van den Eijnden-van Raaij, Janny (author)
Organ-on-Chip is considered a potentially game-changing technology born from the convergence of tissue engineering and microfluidic technology. Organ-on-Chip devices (OoCs) are expected to offer effective solutions to persisting problems in drug development and personalized disease treatments. This opinion paper surveys the current landscape in...
journal article 2019
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Wittig, Corey (author)
Pulmonary arterial hypertension (PAH) is a complex, progressive disease characterized by an increased mean pulmonary arterial pressure at rest, and is associated with a high rate of mortality due to right ventricular failure as the disease progresses. While numerous animal and cell culture models have been created in an attempt to better...
master thesis 2019
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Mastrangeli, Massimo (author), Millet, Sylvie (author), Mummery, Christine (author), Loskill, Peter (author), Braeken, Dries (author), Eberle, Wolfgang (author), Cipriano, Madalena (author), Fernandez, Luis (author), Graef, M.W.M. (author), Gidrol, Xavier (author), Picollet-D'Hahan, Nathalie (author), van Meer, Berend (author), Ochoa, Ignacio (author), Schutte, Mieke (author), van den Eijnden-van Raaij, Janny (author)
This paper summarizes the outcome of the Organ-on-Chip (OoC) ORCHID Strategy workshop (Leiden, the Netherlands, 17 January 2019) intended to establish a European OoC roadmap through expert discussions, conclusions and recommendations. The workshop identified six specific building blocks for the OoC roadmap: (1) application, (2) specification, (3...
journal article 2019
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Croes, M. (author), Kruyt, M. C. (author), Boot, W. (author), Pouran, B. (author), Braham, M. V. (author), Pakpahan, S.A. (author), Weinans, Harrie (author), Vogely, H.C. (author), Fluit, A.C. (author), Dhert, W.J. (author), Alblas, J. (author), Öner, F.C. (author)
Immune cells and their soluble factors regulate skeletal cells during normal bone regeneration and pathological bone formation. Bacterial infections can trigger immune responses that activate pro-osteogenic pathways, but these are usually overshadowed by osteolysis and concerns of systemic inflammation. The aim of this study was to determine...
journal article 2019
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Sharma, Abhishek (author)
A major challenge facing the study of bone regeneration today is the inability to mimic the tissue microenvironment and the factors comprising it. Organ-on-chip based microfluidic systems today aim at doing so by dynamically culturing living cells in them. These are preferred owing to their small feature sizes, laminar flows, high throughput,...
master thesis 2018
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Gelderman, Francisca (author)
In the current day and age, osteogenic bone implants are important to reduce healing time and infections after bone implantation. To help induce bone formation, the implant surface can be biofunctionalized with different agents. A promising surface modification technique used to treat titanium implants is Plasma Electrolytic Oxidation (PEO). In...
master thesis 2018
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