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Slieker, Roderick C. (author), Münch, Magnus (author), Donnelly, Louise A. (author), Bouland, G.A. (author), Dragan, Iulian (author), Kuznetsov, Dmitry (author), Elders, Petra J.M. (author), Rutter, Guy A. (author), Ibberson, Mark (author)Aims/hypothesis: People with type 2 diabetes are heterogeneous in their disease trajectory, with some progressing more quickly to insulin initiation than others. Although classical biomarkers such as age, HbA<sub>1c</sub> and diabetes duration are associated with glycaemic progression, it is unclear how well such variables predict insulin...journal article 2024
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Simons, L.P.A. (author), Pijl, Hanno (author), Verhoef, John (author), Lamb, Hildo J. (author), van Ommen, Ben (author), Gerritsen, B. (author), Bizino, Maurice B. (author), Snel, Marieke (author), Feenstra, R.W. (author), Jonker, C.M. (author)Hybrid e-health support was given to 11 insulin-dependent type 2 diabetes mellitus (DM2) patients, with electronic support plus a multi-disciplinary health support team. Challenges were low ICT and health literacy. After 50 weeks, attractiveness and feasibility of the intervention were perceived as high: recommendation 9.5 out of 10 and...journal article 2022
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Groen, Nathalie (author), Leenders, Floris (author), Mahfouz, A.M.E.T.A. (author), Munoz-Garcia, Amadeo (author), Muraro, Mauro J. (author), de Graaf, Natascha (author), Rabelink, Ton J. (author), Hoeben, Rob (author), Reinders, M.J.T. (author)The maintenance of pancreatic islet architecture is crucial for proper β-cell function. We previously reported that disruption of human islet integrity could result in altered β-cell identity. Here we combine β-cell lineage tracing and single-cell transcriptomics to investigate the mechanisms underlying this process in primary human islet...journal article 2021