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Li, J. (author)Around 10% of the population will have to go through a catheterization procedure for the treatment of a cardiovascular disease at a certain stage of their lives. During such a procedure, smart catheters will be the "eyes and ears" of the surgeons, significantly improving the diagnosis and treatment. However, there have been very limited...doctoral thesis 2024
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Kawasaki, S. (author)CMUTs (Capacitive Micromachined Ultrasonic Transducers) are causing a technological revolution. Research over the last decade showed that CMUTs can sufficiently replace traditional ultrasound technology based on the bulk PZT, along with other benefits such as lower assembly cost, broader bandwidth and monolithic integration capability with ASICs...doctoral thesis 2024
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Moisello, Elisabetta (author), Novaresi, Lara (author), Eshani Sarkar, E. (author), Malcovati, Piero (author), Lopes Marta da Costa, T.M. (author), Bonizzoni, Edoardo (author)Piezoelectric Micromachined Ultrasonic Transducers (PMUT) and Capacitive Micromachined Ultrasonic Transducers (CMUT) have seen great developments in recent years, both in terms of performance and scope of applications within the biomedical ultrasound domain. This paper presents a review of the state-of-the-art of PMUT and CMUT technologies,...review 2024
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Simoes dos Santos, D. (author), Ossenkoppele, B.W. (author), Hopf, Y.M. (author), Soozande, Mehdi (author), Noothout, E.C. (author), Vos, H.J. (author), Bosch, Johan G. (author), Pertijs, M.A.P. (author), Verweij, M.D. (author), de Jong, N. (author)Objective: Described here is the development of an ultrasound matrix transducer prototype for high-frame-rate 3-D intra-cardiac echocardiography. Methods: The matrix array consists of 16 × 18 lead zirconate titanate elements with a pitch of 160 µm × 160 µm built on top of an application-specific integrated circuit that generates transmission...journal article 2024
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Kortenbout, A.J. (author), Costerus, Sophie (author), Dudink, Jeroen (author), de Jong, N. (author), de Graaff, Jurgen C. (author), Vos, H.J. (author), Bosch, Johan G. (author)Objective: Post-operative brain injury in neonates may result from disturbed cerebral perfusion, but accurate peri-operative monitoring is lacking. High-frame-rate (HFR) cerebral ultrasound could visualize and quantify flow in all detectable vessels using spectral Doppler; however, automated quantification in small vessels is challenging...journal article 2024
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Simoes dos Santos, D. (author), Baldini, L.B. (author), Vos, H.J. (author), Verweij, M.D. (author), de Jong, N. (author), van Neer, P.L.M.J. (author)The accurate determination of the transfer function of ultrasound transducers is important for their design and operational performance. However, conventional methods for quantifying the transfer function, such as hydrophone measurements, radiation force balance, and pulse-echo measurements, are costly and complex due to specialized equipment...journal article 2024
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Zhu, P. (author), Simón Grau, I. (author), Kokalari, I. (author), Kohane, Daniel S. (author), Rwei, A.Y. (author)Ultrasound is a promising technology to address challenges in drug delivery, including limited drug penetration across physiological barriers and ineffective targeting. Here we provide an overview of the significant advances made in recent years in overcoming technical and pharmacological barriers using ultrasound-assisted drug delivery to...review 2024
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Hopf, Y.M. (author), Simoes dos Santos, D. (author), Ossenkoppele, Boudewine W. (author), Noothout, E.C. (author), Chang, Z.Y. (author), Chen, Chao (author), Vos, H.J. (author), Verweij, M.D. (author), de Jong, N. (author), Pertijs, M.A.P. (author)This article presents an application-specific integrated circuit (ASIC) for catheter-based 3-D ultrasound imaging probes. The pitch-matched design implements a comprehensive architecture with high-voltage (HV) transmitters, analog front ends, hybrid beamforming analog-To-digital converters (ADCs), and data transmission to the imaging system....journal article 2024
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Smith, Caitlin (author), Shepherd, Jami (author), Renaud, G.G.J. (author), van Wijk, Kasper (author)We present a technique called photoacoustic vector-flow (PAVF) to quantify the speed and direction of flowing optical absorbers at each pixel from acoustic-resolution PA images. By varying the receiving angle at each pixel in post-processing, we obtain multiple estimates of the phase difference between consecutive frames. These are used to...journal article 2024
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Eenkhoorn, C. (author), Goos, T.G. (author), Dankelman, J. (author), Franx, Arie (author), Eggink, Alex J. (author)Introduction: In clinical practice, fetal heart rate monitoring is performed intermittently using Doppler ultrasound, typically for 30 minutes. In case of a non-reassuring heart rate pattern, monitoring is usually prolonged. Noninvasive fetal electrocardiography may be more suitable for prolonged monitoring due to improved patient comfort and...journal article 2024
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Guo, P. (author)This thesis presents the design and implementation of integrated ultrasound transceivers for use in transfontanelle ultrasonography (TFUS). Two generations of ultrasound transceiver ASICs integrated with PZT transducer arrays intended for TFUS are presented. In the first generation, a novel AFE design that combines an LNA with the continuous TGC...doctoral thesis 2023
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Ossenkoppele, B.W. (author)High-frame-rate volumetric ultrasound imaging is highly desired to enable novel clinical ultrasound applications. However, realizing high-quality volumetric ultrasound imaging at a high frame rates (>500 Hz) is challenging. Keeping the cable count and data rate of the transducer device at a realistic level without sacrificing image quality to...doctoral thesis 2023
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Hopf, Y.M. (author)This thesis describes the design of application-specific integrated circuits (ASICs) for high-frame-rate 3D intracardiac echocardiography (ICE) probes. The work follows the whole process from the analysis of the application to the testing of a prototype with all envisioned functionality. It starts with the evaluation of the main challenges posed...doctoral thesis 2023
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van der Meulen, P.Q. (author)Whereas aberrating layers are typically viewed as an impediment to medical ultrasound imaging, they can, surprisingly, also be used to our benefit. As long as we can model the effect of an aberrating layer, we can utilize ‘model-based imaging’, the imaging technique explored throughout this thesis, to reconstruct ultrasound images where...doctoral thesis 2023
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Saccher, M. (author), Kawasaki, S. (author), Klootwijk, Johan (author), van Schaijk, Rob (author), Dekker, R. (author)Recently, the applications of ultrasound transducers expanded from high-end diagnostic tools to point of care diagnostic devices and wireless power receivers for implantable devices. These new applications additionally require that the transducer technology must comply to biocompatibility and manufacturing scalability. In this respect,...journal article 2023
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Biagini, D. (author), Pascoe, J.A. (author), Alderliesten, R.C. (author)Impacts on carbon fiber reinforced composites (CFRP) can produce a complex internal damage comprising multiple delaminations, which is hard to detect from visual inspection. This situation is known as barely visible impact damage (BVID). Considering that every airplane faces several impacts during its operational life, and that the majority of...conference paper 2023
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Rodrigues, Estevão P. (author), Simoes dos Santos, D. (author), Buiochi, Flávio (author)The measurement of acoustic fields generated by ultrasonic transducers is important for determining the focal length, lateral resolution, and amplitudes of the lateral and grating lobes. The acoustic field is commonly characterized by a set of scans using a needle hydrophone. The output of the hydrophone can be connected to an analog filter to...journal article 2023
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Generowicz, Bastian S. (author), Dijkhuizen, Stephanie (author), Bosman, Laurens W.J. (author), De Zeeuw, Chris I. (author), Koekkoek, Sebastiaan K.E. (author), Kruizinga, P. (author)Functional ultrasound (fUS) using a 1-D-array transducer normally is insufficient to capture volumetric functional activity due to being restricted to imaging a single brain slice at a time. Typically, for volumetric fUS, functional recordings are repeated many times as the transducer is moved to a new location after each recording, resulting...journal article 2023
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Wahyulaksana, G. (author), Wei, Luxi (author), Voorneveld, J.D. (author), Hekkert, Maaike Te Lintel (author), Strachinaru, Mihai (author), Duncker, Dirk J. (author), de Jong, N. (author), van der Steen, A.F.W. (author), Vos, H.J. (author)Assessing the coronary circulation with contrast-enhanced echocardiography has high clinical relevance. However, it is not being routinely performed in clinical practice because the current clinical tools generally cannot provide adequate image quality. The contrast agent's visibility in the myocardium is generally poor, impaired by motion...journal article 2023
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Li, H. (author), Li, X. (author), Collado Lara, G. (author), Lattwein, K.R. (author), Mastik, Frits (author), Beurskens, Robert (author), van der Steen, A.F.W. (author), Verweij, M.A. (author), de Jong, N. (author), Kooiman, Klazina (author)Ultrasound contrast-mediated medical imaging and therapy both rely on the dynamics of micron- and nanometer-sized ultrasound cavitation nuclei, such as phospholipid-coated microbubbles and phase-change droplets. Ultrasound cavitation nuclei respond non-linearly to ultrasound on a nanosecond time scale that necessitates the use of ultra-high...journal article 2023