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Cruz Saldivar, M. (author), Tay, E.T.W.S. (author), Isaakidou, A. (author), Moosabeiki, Vahid (author), Fratila-Apachitei, E.L. (author), Doubrovski, E.L. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)Durable interfacing of hard and soft materials is a major design challenge caused by the ensuing stress concentrations. In nature, soft-hard interfaces exhibit remarkable mechanical performance, with failures rarely happening at the interface. Here, we mimic the strategies observed in nature to design efficient soft-hard interfaces. We base...journal article 2023
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Deep Learning for Size-Agnostic Inverse Design of Random-Network 3D Printed Mechanical MetamaterialsPahlavani, H. (author), Tsifoutis-Kazolis, Kostas (author), Cruz Saldivar, M. (author), Mody, Prerak (author), Zhou, J. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)Practical applications of mechanical metamaterials often involve solving inverse problems aimed at finding microarchitectures that give rise to certain properties. The limited resolution of additive manufacturing techniques often requires solving such inverse problems for specific specimen sizes. Moreover, the candidate microarchitectures...journal article 2023
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Putra, N.E. (author), Leeflang, M.A. (author), Ducret, Verena (author), Patrulea, Viorica (author), Fratila-Apachitei, E.L. (author), Perron, Karl (author), Ye, Hua (author), Zhou, J. (author), Apachitei, I. (author), Zadpoor, A.A. (author)Implant-associated infections are highly challenging to treat, particularly with the emergence of multidrug-resistant microbials. Effective preventive action is desired to be at the implant site. Surface biofunctionalization of implants through Ag-doping has demonstrated potent antibacterial results. However, it may adversely affect bone...journal article 2022
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Kolken, H.M.A. (author), Garcia, A. Fontecha (author), Plessis, A. Du (author), Meynen, A. (author), Rans, C.D. (author), Scheys, L. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)The fatigue performance of additively manufactured auxetic meta-biomaterials made from commercially pure titanium has been studied only recently. While certain assumptions have been made regarding the mechanisms underlying their fatigue failure, the exact mechanisms are not researched yet. Here, we studied the mechanisms of crack formation...journal article 2022
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Ganjian, M. (author), Janbaz, S. (author), van Manen, T. (author), Tümer, N. (author), Modaresifar, K. (author), Minneboo, M.B. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)We designed and fabricated a simple setup for the controlled crumpling of nanopatterned, surface-porous flat metallic sheets for the fabrication of volume-porous biomaterials and showed that crumpling can be considered as an efficient alternative to origami-inspired folding. Before crumpling, laser cutting was used to introduce pores to the...journal article 2022
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Dong, J. (author), Lin, P. (author), Putra, N.E. (author), Tümer, N. (author), Leeflang, M.A. (author), Huan, Z. (author), Fratila-Apachitei, E.L. (author), Chang, J. (author), Zadpoor, A.A. (author), Zhou, J. (author)The treatment of femoral nonunion with large segmental bone defect is still challenging. Although magnesium alloys have been considered potential materials for such a treatment, their application is limited by their fast degradation. Adding bioceramic particles into magnesium to form Mg-matrix composites is a promising strategy to adjust...journal article 2022
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Willemsen, Koen (author), Tryfonidou, Marianna (author), Sakkers, Ralph (author), Castelein, René M. (author), Zadpoor, A.A. (author), Seevinck, Peter (author), Weinans, Harrie (author), Meij, Björn (author), van der Wal, Bart C.H. (author)A solution for challenging hip dysplasia surgery could be a patient-specific 3D-printed shelf implant that is positioned extra-articular and restores the dysplastic acetabular rim to normal anatomical dimensions. The anatomical correction and biomechanical stability of this concept were tested in a canine model that, like humans, also suffers...journal article 2022
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Garner, E. (author), Wu, J. (author), Zadpoor, A.A. (author)Recent advances in 3D printable micro-architected materials offer unprecedented possibilities for the development of highly tailored orthopaedic implants. These devices, which are typically made from fully solid materials, significantly alter load transmission to the surrounding bone tissue, potentially leading to interface instability and bone...journal article 2022
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Angeloni, L. (author), Popa, Bogdan (author), Nouri Goushki, M. (author), Minneboo, M.B. (author), Zadpoor, A.A. (author), Ghatkesar, M.K. (author), Fratila-Apachitei, E.L. (author)Physical patterns represent potential surface cues for promoting osteogenic differentiation of stem cells and improving osseointegration of orthopedic implants. Understanding the early cell–surface interactions and their effects on late cellular functions is essential for a rational design of such topographies, yet still elusive. In this work...journal article 2022
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San, H. (author), Paresoglou, M. (author), Minneboo, M.B. (author), van Hengel, I.A.J. (author), Yilmaz, A. (author), Gonzalez Garcia, Y. (author), Fluit, Ad C. (author), Hagedoorn, P.L. (author), Fratila-Apachitei, E.L. (author), Apachitei, I. (author), Zadpoor, A.A. (author)Nanoparticles (NPs) have high multifunctional potential to simultaneously enhance implant osseointegration and prevent infections caused by antibiotic-resistant bacteria. Here, we present the first report on using plasma electrolytic oxidation (PEO) to incorporate different combinations of reduced graphene oxide (rGO) and silver (Ag) NPs on...journal article 2022
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Modaresifar, K. (author), Ganjian, M. (author), Diaz Payno, P.J. (author), Klimopoulou, M. (author), Koedam, Marijke (author), van der Eerden, B.C.J. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)Black Ti (bTi) surfaces comprising high aspect ratio nanopillars exhibit a rare combination of bactericidal and osteogenic properties, framing them as cell-instructive meta-biomaterials. Despite the existing data indicating that bTi surfaces induce osteogenic differentiation in cells, the mechanisms by which this response is regulated are not...journal article 2022
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van Kootwijk, A. (author), Moosabeiki, Vahid (author), Cruz Saldivar, M. (author), Pahlavani, H. (author), Leeflang, M.A. (author), Kazemivand Niar, S. (author), Tümer, N. (author), Mirzaali, Mohammad J. (author), Zhou, J. (author), Zadpoor, A.A. (author)The reconstruction of large mandibular defects with optimal aesthetic and functional outcomes remains a major challenge for maxillofacial surgeons. The aim of this study was to design patient-specific mandibular reconstruction implants through a semi-automated digital workflow and to assess the effects of topology optimization on the...journal article 2022
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Putra, N.E. (author), Borg, K. G.N. (author), Diaz Payno, P.J. (author), Leeflang, M.A. (author), Klimopoulou, M. (author), Taheri, P. (author), Mol, J.M.C. (author), Fratila-Apachitei, E.L. (author), Zhou, J. (author), Zadpoor, A.A. (author)Advanced additive manufacturing techniques have been recently used to tackle the two fundamental challenges of biodegradable Fe-based bone-substituting materials, namely low rate of biodegradation and insufficient bioactivity. While additively manufactured porous iron has been somewhat successful in addressing the first challenge, the limited...journal article 2022
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Pahlavani, H. (author), Amani, M. (author), Cruz Saldivar, M. (author), Zhou, J. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)Emerging multi-material 3D printing techniques enables the rational design of metamaterials with not only complex geometries but also arbitrary distributions of multiple materials within those geometries, yielding unique combinations of elastic properties. However, discovering the rare designs that lead to highly unusual combinations of...journal article 2022
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Diaz Payno, P.J. (author), Kalogeropoulou, Maria (author), Muntz, I.A.A. (author), Kingma, Esther (author), Kops, Nicole (author), D'Este, Matteo (author), Koenderink, G.H. (author), Fratila-Apachitei, E.L. (author), van Osch, G.J.V.M. (author), Zadpoor, A.A. (author)3D bioprinting is usually implemented on flat surfaces, posing serious limitations in the fabrication of multilayered curved constructs. 4D bioprinting, combining 3D bioprinting with time-dependent stimuli-induced transformation, enables the fabrication of shape-changing constructs. Here, a 4D biofabrication method is reported for cartilage...journal article 2022
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van Manen, T. (author), Moosabeiki, Vahid (author), Cruz Saldivar, M. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)4D printing of flat sheets that self-fold into architected 3D structures is a powerful origami-inspired approach for the fabrication of multi-functional devices and metamaterials. However, the opposite stiffness requirements for the folding process and the subsequent loadbearing of 3D structures impose an intrinsic limitation in designing...journal article 2022
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Putra, N.E. (author), Tigrine, A. (author), Aksakal, S. (author), de la Rosa, V. R. (author), Taheri, P. (author), Fratila-Apachitei, E.L. (author), Mol, J.M.C. (author), Zhou, J. (author), Zadpoor, A.A. (author)Additively manufacturing of porous iron offers a unique opportunity to increase its biodegradation rate by taking advantage of arbitrarily complex porous structures. Nevertheless, achieving the required biodegradation profile remains challenging due to the natural passivation of iron that decrease the biodegradation rate. Moreover, the...journal article 2022
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Dong, J. (author), Tümer, N. (author), Leeflang, M.A. (author), Taheri, P. (author), Fratila-Apachitei, E.L. (author), Mol, J.M.C. (author), Zadpoor, A.A. (author), Zhou, J. (author)Porous biodegradable Mg and its alloys are considered to have a great potential to serve as ideal bone substitutes. The recent progress in additive manufacturing (AM) has prompted its application to fabricate Mg scaffolds with geometrically ordered porous structures. Extrusion-based AM, followed by debinding and sintering, has been recently...journal article 2022
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Ganjian, M. (author), Modaresifar, K. (author), Rompolas, Dionysios (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)Developing high-throughput nanopatterning techniques that also allow for precise control over the dimensions of the fabricated features is essential for the study of cell-nanopattern interactions. Here, we developed a process that fulfills both of these criteria. Firstly, we used electron-beam lithography (EBL) to fabricate precisely...journal article 2022
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Kolken, H.M.A. (author), Callens, S.J.P. (author), Leeflang, M.A. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)The rational design of bone-substituting biomaterials is relatively complex because they should meet a long list of requirements for optimal performance. Meta-biomaterials are micro-architected materials that hold great promise for meeting those requirements as they offer a unique combination of mechanical, mass-transport, and biological...journal article 2022
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