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Bouland, G.A. (author), Mahfouz, A.M.E.T.A. (author), Reinders, M.J.T. (author)With the number of cells measured in single-cell RNA sequencing (scRNA-seq) datasets increasing exponentially and concurrent increased sparsity due to more zero counts being measured for many genes, we demonstrate here that downstream analyses on binary-based gene expression give similar results as count-based analyses. Moreover, a binary...journal article 2023
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Faber, J.S. (author), Poot, Charlotte C. (author), Dekkers, Tessa (author), Romero Herrera, N.A. (author), Chavannes, N.H. (author), Meijer, Eline (author), Visch, V.T. (author)Background: Current eHealth interventions are poorly adopted by people with low health literacy (LHL) as they often fail to meet their needs, skills, and preferences. A major reason for this poor adoption is the generic, one-size-fits-all approach taken by designers of these interventions, without addressing the needs, skills, and preferences...journal article 2023
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Ranjan, R. (author), Langelaar, Matthijs (author), van Keulen, A. (author), Ayas, C. (author)Computational process modelling of metal additive manufacturing has gained significant research attention in recent past. The cornerstone of many process models is the transient thermal response during the AM process. Since deposition-scale modelling of the thermal conditions in AM is computationally expensive, spatial and temporal...journal article 2023
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Cruz Saldivar, M. (author), Tay, E.T.W.S. (author), Isaakidou, A. (author), Moosabeiki, Vahid (author), Fratila-Apachitei, E.L. (author), Doubrovski, E.L. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)Durable interfacing of hard and soft materials is a major design challenge caused by the ensuing stress concentrations. In nature, soft-hard interfaces exhibit remarkable mechanical performance, with failures rarely happening at the interface. Here, we mimic the strategies observed in nature to design efficient soft-hard interfaces. We base...journal article 2023
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Faber, J.S. (author), Al-Dhahir, Isra (author), Kraal, J.J. (author), Breeman, Linda D. (author), Reijnders, Thomas (author), van Dijk, S. (author), Visch, V.T. (author), Chavannes, N.H. (author), Evers, A.W.M. (author)BACKGROUND: People with a low socioeconomic position (SEP) are less likely to benefit from eHealth interventions, exacerbating social health inequalities. Professionals developing eHealth interventions for this group face numerous challenges. A comprehensive guide to support these professionals in their work could mitigate these inequalities....journal article 2023
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Copeland, S.M. (author), Hinrichs-Krapels, S. (author), Fecondo, Federica (author), Santizo, Esteban Ralon (author), Bal, Roland (author), Comes, M. (author)BACKGROUND: Prompted by recent shocks and stresses to health systems globally, various studies have emerged on health system resilience. Our aim is to describe how health system resilience is operationalised within empirical studies and previous reviews. We compare these to the core conceptualisations and characteristics of resilience in a...journal article 2023
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Cosma, Bianca-Maria (author), Shirali Hossein Zade, R. (author), Jordan, E.N. (author), van Lent, P.H. (author), Peng, C. (author), Pillay, S. (author), Abeel, T.E.P.M.F. (author)Background: Assembly algorithm choice should be a deliberate, well-justified decision when researchers create genome assemblies for eukaryotic organisms from third-generation sequencing technologies. While third-generation sequencing by Oxford Nanopore Technologies (ONT) and Pacific Biosciences (PacBio) has overcome the disadvantages of short...journal article 2023
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Abunahla, H.N. (author), Abbas, Yawar (author), Gebregiorgis, A.B. (author), Waheed, Waqas (author), Mohammad, Baker (author), Hamdioui, S. (author), Alazzam, Anas (author), Rezeq, Moh’d (author)Advances in materials science and memory devices work in tandem for the evolution of Artificial Intelligence systems. Energy-efficient computation is the ultimate goal of emerging memristor technology, in which the storage and computation can be done in the same memory crossbar. In this work, an analog memristor device is fabricated utilizing...journal article 2023
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Gründemann, Gaby J. (author), Zorzetto, E. (author), van de Giesen, N.C. (author), van der Ent, R.J. (author)Global warming impacts the hydrological cycle, affecting the seasonality and timing of extreme precipitation. Understanding historical changes in extreme precipitation occurrence is crucial for assessing their impacts. This study uses relative entropy to analyze historical changes in seasonality and timing of extreme daily precipitation...journal article 2023
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Ceria, A. (author), Wang, H. (author)Human social interactions are typically recorded as time-specific dyadic interactions, and represented as evolving (temporal) networks, where links are activated/deactivated over time. However, individuals can interact in groups of more than two people. Such group interactions can be represented as higher-order events of an evolving network....journal article 2023
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Tišma, M. (author), Janissen, R. (author), Antar, Hammam (author), Martin Gonzalez, A. (author), Barth, R. (author), Beekman, T.G.T. (author), van der Torre, J. (author), Michieletto, Davide (author), Gruber, Stephan (author), Dekker, C. (author)In most bacteria, chromosome segregation is driven by the ParABS system where the CTPase protein ParB loads at the parS site to trigger the formation of a large partition complex. Here, we present in vitro studies of the partition complex for Bacillus subtilis ParB, using single-molecule fluorescence microscopy and AFM imaging to show that...journal article 2023
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Gorkovenko, Katerina (author), Jenkins, Adam (author), Vaniea, Kami (author), Murray-Rust, D.S. (author)Research in the wild can reveal human behaviors, contexts, and needs around products that are difficult to observe in the lab. Telemetry data from the use of physical products can help facilitate in the wild research, in particular by suggesting hypotheses that can be explored through machine learning models. This paper explores ways for...journal article 2023
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Pols, C.F.J. (author), Dekkers, P.J.J.M. (author), de Vries, M.J. (author)Physics inquiry can be interpreted as the construction of a cogent argument in which students apply inquiry knowledge and knowledge of physics to the systematic collection of relevant, valid, and reliable data, creating optimal scientific support for a conclusion that answers the research question. In learning how to devise, conduct and evaluate...journal article 2022
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Schaeken, Teun (author), Hoogerbrugge, L.A. (author), Verschuur, D.J. (author)The acoustic wave equation describes wave propagation directly from basic physical laws, even in heterogeneous acoustic media. When numerically simulating waves with the wave equation, contrasts in the medium parameters automatically generate all scattering effects. For some applications - such as propagation analysis or certain wave-equation...journal article 2022
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Tielen, R.P.W.M. (author), Möller, M. (author), Vuik, Cornelis (author)The use of sequential time integration schemes becomes more and more the bottleneck within large-scale computations due to a stagnation of processor’s clock speeds. In this study, we combine the parallel-in-time Multigrid Reduction in Time method with a p-multigrid method to obtain a scalable solver specifically designed for Isogeometric...journal article 2022
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Dutta, S. (author), Chen, Zhiyi (author), Kaiser, Elias (author), Malcolm Matamoros, Priscilla (author), Steeneken, P.G. (author), Verbiest, G.J. (author)Although it is well known that plants emit acoustic pulses under drought stress, the exact origin of the waveform of these ultrasound pulses has remained elusive. Here, we present evidence for a correlation between the characteristics of the waveform of these pulses and the dimensions of xylem conduits in plants. Using a model that relates the...journal article 2022
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de Leeuw den Bouter, M.L. (author), Ippolito, G. (author), O’Reilly, T. P.A. (author), Remis, R.F. (author), van Gijzen, M.B. (author), Webb, A. (author)Low-field MRI scanners are significantly less expensive than their high-field counterparts, which gives them the potential to make MRI technology more accessible all around the world. In general, images acquired using low-field MRI scanners tend to be of a relatively low resolution, as signal-to-noise ratios are lower. The aim of this work is...journal article 2022
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De Vries, Laurens (author), Sanchez Jimenez, I.J. (author)Existing indicators of electricity system adequacy need to be supplemented with economic performance indicators. As power systems are decarbonized, energy storage technologies are being developed and demand is becoming more flexible. Reliability standards need to reflect the price elasticity of these sources of flexibility. During scarcity...journal article 2022
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Willemet, L. (author), Huloux, Nicolas (author), Wiertlewski, M. (author)When grasping objects, we rely on our sense of touch to adjust our grip and react against external perturbations. Less than 200 ms after an unexpected event, the sensorimotor system is able to process tactile information to deduce the frictional strength of the contact and to react accordingly. Given that roughly 1,300 afferents innervate the...journal article 2022
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Steffelbauer, D.B. (author), Riva, R.E.M. (author), Timmermans, Jos (author), Kwakkel, J.H. (author), Bakker, M. (author)Global mean sea-level rise (SLR) has accelerated since 1900 from less than 2 mm yr-1 during most of the century to more than 3 mm yr-1 since 1993. Decision-makers in coastal countries, however, require information on SLR at the regional scale, where detection of an acceleration in SLR is difficult, because the long-term sea-level signal is...journal article 2022