We develop and apply the concept of equitable knowledge co-production (EKC) by proposing a reflexive framework to support inclusive stakeholder engagement with diverse knowledge-holders. This framework is built on the authors’ experiences of leading three ongoing Horizon 2020 projects, and its goal is to contribute to the realisation of epistemic and recognition justice in the context of large-scale research and innovation projects by raising awareness of how knowledge co-production is carried out during the project proposal and implementation phases.